Circulating ghrelin levels in obese women: a possible association with hypertension

Doğan, Yüksel; Koçak, Hülya; Gürdöl, Figen; Öner, Pernur; İşsever, Halim; Esin, Deniz

doi:10.1080/00365510701210186

Cited by 29 publications

(21 citation statements)

References 15 publications

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“…Finally, although a negative correlation between blood pressure and ghrelin levels has been found in previous studies [40, 41], we were not able to confirm this finding. A possible explanation may be an inadequate statistical power to demonstrate such a correlation in a small cohort.…”

Section: Discussioncontrasting

confidence: 94%

Testosterone Is a Strong Correlate of Ghrelin Levels in Men and Postmenopausal Women

et al. 2008

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Background/Aims: The secretion and regulation of several hormones such as leptin and growth hormone (GH) is sexually dimorphic. Gender effects on ghrelin, a hormone involved in the regulation of GH secretion and appetite control, are controversial. Our aim was to study the relationship between plasma ghrelin and serum sex steroid hormone concentrations. Methods: Forty-five subjects (19 men, 12 premenopausal and 14 postmenopausal women) were evaluated at the Institute of Endocrinology and Metabolism, Tel Aviv Sourasky Medical Center, Israel. After an overnight fast, blood samples were collected for measurements of ghrelin, testosterone, bioavailable testosterone (BT) and estradiol. Statistical analysis was performed with adjustments for age and body mass index. Results are given as mean ± standard deviation. Results: Ghrelin levels were significantly higher in women (510 ± 489 pg/ml) than in men (319 ± 237 pg/ml; p = 0.02). There was a positive correlation between ghrelin and both total testosterone (r = 0.5, p = 0.039) and BT (r = 0.719, p = 0.0011) in male subjects. In premenopausal women, no significant correlations were found between ghrelin and testosterone or BT (r = –0.39, p = 0.2). In contrast, ghrelin strongly and positively correlated with total testosterone (r = 0.7, p = 0.01) and BT (r = 0.821, p = 0.001) in postmenopausal women. Estradiol and ghrelin were positively correlated in the group as a whole (r = 0.356, p = 0.019), but not significantly when analyzed separately by gender. Conclusions: Circulating ghrelin in humans is sexually dimorphic. Testosterone correlates positively with ghrelin levels in men and postmenopausal women.

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Section: Discussioncontrasting

confidence: 94%

Testosterone Is a Strong Correlate of Ghrelin Levels in Men and Postmenopausal Women

et al. 2008

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“…Obesity is a complex pathology with interacting and confounding causes proposed from the environment, hormonal signaling patterns, adipogenic pathogens, genetic predispositions, adipokine receptor defects, and numerous behavioral aspects such as eating disorders, inadequate portion control, and decreased physical activity [5][6][7][8][9][10][11][12][13][14][15][16]. Although the etiology of obesity can be extremely complicated, a central imbalance in caloric homeostasis is the primary contributing factor to this condition [17].…”

Section: Introductionmentioning

confidence: 99%

Obesity and vascular dysfunction

et al. 2008

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One of the most profound challenges facing public health and public health policy in Western society is the increased incidence and prevalence of both overweight and obesity. While this condition can have significant consequences for patient mortality and quality of life, it can be further exacerbated as overweight/obesity can be a powerful stimulus for the development of additional risk factors for a negative cardiovascular outcome, including increased insulin resistance, dyslipidemia and hypertension. This manuscript will present the effects of systemic obesity on broad issues of vascular function in both afflicted human populations and in the most relevant animal models. Among the topics that will be covered are alterations to vascular reactivity (both dilator and constrictor responses), adaptations in microvascular network and vessel wall structure, and alterations to the patterns of tissue/organ perfusion as a result of the progression of the obese condition. Additionally, special attention will be paid to the contribution of chronic inflammation as a contributor to alterations in vascular function, as well as the role of perivascular adipose tissue in terms of impacting vessel behavior. When taken together, it is clearly apparent that the development of the obese condition can have profound, and frequently difficult to predict, impacts on integrated vascular function. Much of this complexity appears to have its basis in the extent to which other co-morbidities associated with obesity (e.g., insulin resistance) are present and exert contributing effects.

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“…As seen in Table 1, serum levels of ghrelin show a wide range of distribution. This may not be related to the sample size or the type of assay because it seems to be a common issue (29)(30)(31). On the other hand, our study contributes to the literature as it is particularly the first to investigate the changes in circulating ghrelin after blood pressure control in treatment native hypertensive subjects without any complications.…”

Section: Study Limitationsmentioning

confidence: 89%

Effects of valsartan treatment on serum ghrelin level and left ventricular mass index in patients with untreated primary hypertension

Meriç¹,

Aydoğdu²,

Taşçı³

et al. 2014

Anadolu Kardiyol Derg

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Objective: In the present study, left ventricular hypertrophy and serum ghrelin concentration in patients with primary hypertension and effects of angiotensin receptor blocker valsartan on these parameters were determined. Methods: Thirty-seven patients and 30 age and body mass index matched healthy controls were followed up prospectively. Serum ghrelin level was measured by enzyme immunoassay (EIA). Left ventricular mass was determined by transthoracic echocardiography. Left ventricular mass index (LVMI) was calculated by dividing the left ventricular mass to body surface area. All patients were started treatment with oral valsartan 80 mg. Follow-up visits were performed every 4 weeks, and the dosage was doubled in subjects with insufficient blood pressure reduction. At the end of the 12 th week all measurements were repeated in the patient group. All data were recorded in the computer using SPSS for Windows software. Mann-Whitney U, Student t, Wilcoxon and t tests were used for statistical analyses. Results: At baseline, mean serum ghrelin level was significantly lower in the patients group (14.9 ng/mL) compared to healthy controls (42.1 ng/mL) (p<0.05). After a 12-week antihypertensive treatment of patients, serum ghrelin concentration increased while LVMI decreased (p<0.05, for both). No significant correlation was found between Δ-ghrelin level and Δ-LVMI (r=0.155, p=0.368). Conclusion: Low circulating level of ghrelin in patients with hypertension and its increase after antihypertensive treatment suggest that this peptide need to be explored in the mechanism and complications of hypertension. (Anadolu Kardiyol Derg 2014; 14: 234-8)

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Circulating ghrelin levels in obese women: a possible association with hypertension

Abstract: Ghrelin was positively associated with hypertension in obese women and this association was inversely influenced by the increase of BMI.

Cited by 29 publications

References 15 publications

Testosterone Is a Strong Correlate of Ghrelin Levels in Men and Postmenopausal Women

Testosterone Is a Strong Correlate of Ghrelin Levels in Men and Postmenopausal Women

Obesity and vascular dysfunction

Effects of valsartan treatment on serum ghrelin level and left ventricular mass index in patients with untreated primary hypertension

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