Circulating ghrelin in patients with chronic obstructive pulmonary disease

Luo, Fengming; Liu, Xiaojing; Li, Shuangqing; Wang, Zengli; Liu, Chun‐Tao; Yuan, Yujia

doi:10.1016/j.nut.2004.11.015

Cited by 39 publications

(31 citation statements)

References 25 publications

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“…Similar results were obtained by Luo et al, in patients suffering from chronic obstructive pulmonary disease (20). However, this association did not remain significant after controlling for total adiposity.…”

Section: Dependent Variablesupporting

confidence: 88%

“…Recent studies have provided conflicting information regarding interactions of fasting TotG with CRP and TNF-a in patients with different chronic diseases (20,21). However, these relationships were never evaluated in a model of obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, recent advances suggest that TNF-a increases insulin resistance in skeletal muscle, hepatocytes, and adipose tissues by decreasing the expression of glucose transporter-4 and insulin receptor substrate-2 (37)(38)(39). Previous authors have reported that fasting AcylG levels are negatively correlated with circulating TNF-a concentrations in women with gestational diabetes mellitus and TotG in patients with chronic pulmonary diseases (20,40). In contrast, a positive association was observed between fasting TotG and TNF-a concentrations in patients with bowel disease, postoperational abdominal sepsis, or chronic heart failure (21,41,42).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, both in vivo and in vitro studies have provided evidence that ghrelin can exert antiinflammatory effects by reducing pro-inflammatory cytokine expression (18,19). In addition, TotG concentrations are negatively correlated with tumor necrosis factor a (TNF-a) and C-reactive protein (CRP) levels in patients with chronic obstructive pulmonary diseases (20). On the other hand, TotG levels are positively associated with TNF-a in subjects with chronic heart failure (21).…”

Section: Introductionmentioning

confidence: 99%

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Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study

St-Pierre

Bastard²,

Coderre³

et al. 2007

eur j endocrinol

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Objective: Recent reports have suggested that the existence of associations between hormonal dysregulation and chronic upregulation of inflammatory markers, which may cause obesity-related disturbances. Thus, we examined whether acylated ghrelin (AcylG) and total ghrelin (TotG) levels could be associated with the following inflammatory markers: C-reactive protein (CRP), tumor necrosis factor a (TNF-a), and soluble TNF receptor 1 (sTNF-R1). Design: Cross-sectional study consisting of 50 overweight and obese postmenopausal women. Methods: AcylG and TotG levels were assessed at 0, 60, 160, 170, and 180 min of the euglycemic/hyperinsulinemic clamp (EHC). We evaluated insulin sensitivity, body composition, and blood lipid profiles as well as fasting concentrations of CRP, TNF-a, and sTNF-R1. Results: In fasting conditions, sTNF-R1 was negatively correlated with AcylG (rZK0.48, P!0.001) levels. In addition, AcylG/TotG was associated negatively with sTNF-R1 (rZK0.44, PZ0.002) and positively with TNF-a (rZ0.38, PZ0.009) values. During the EHC, TotG (at all time points) and AcylG (at 60 and 160 min) values were significantly decreased from fasting concentrations. AcylG maximal reduction and area under the curve (AUC) values were correlated to sTNF-R1 (rZK0.35, PZ0.02 and rZK0.34, PZ0.02, respectively). Meanwhile, the AcylG/TotG AUC ratio was associated negatively with sTNF-R1 (rZK0.29, P!0.05) and positively with TNF-a (rZ0.36, PZ0.02). Following adjustments for total adiposity, sTNF-R1 remained correlated with fasting and maximal reduction AcylG values. Similarly, AcylG/TotG ratios remained significantly correlated with sTNF-R1 and TNF-a. Importantly, 23% of the variation in sTNF-R1 was independently predicted by fasting AcylG. Conclusion: These results are the first to suggest that both fasting and EHC-induced AcylG profiles are correlated with fasting values of sTNF-R1, a component of the TNF-a system. Thus, AcylG may act, at least in part, as one mediator of chronic inflammatory activity in human obesity. European Journal of Endocrinology 157 419-426

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Section: Dependent Variablesupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study

St-Pierre

Bastard²,

Coderre³

et al. 2007

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…In the studies carried out on chronic obstructive pulmonary diseases (COPD) patients, a negative correlation between the ghrelin levels and CRP levels was observed (23). However, Barros et al reported that the serum ghrelin levels were significantly higher in hemodialysis patients, but no significant correlation was found between the inflammatory and ghrelin factors (24).…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study

Mahmoodnia¹,

Beigrezaei²,

Tamadon³

et al. 2018

J Nephropathol

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Sex Differences in Muscle Wasting

Anderson

Liu

García

2017

Advances in Experimental Medicine and Biology

166

131

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With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration. Estrogens have a protective effect on skeletal muscle by attenuating inflammation; however, the mechanisms of estrogen action in skeletal muscle are less well characterized than those of testosterone. Age- and/or disease-induced alterations in sex hormones are major contributors to muscle wasting. Hence, men and women may respond differently to catabolic conditions because of their hormonal profiles. Here we review the similarities and differences between men and women with common wasting conditions including sarcopenia and cachexia due to cancer, end-stage renal disease/chronic kidney disease, liver disease, chronic heart failure, and chronic obstructive pulmonary disease based on the literature in clinical studies. In addition, the responses in men and women to the commonly used therapeutic agents and their efficacy to improve muscle mass and function are also reviewed.

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Circulating ghrelin in patients with chronic obstructive pulmonary disease

Cited by 39 publications

References 25 publications

Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study

Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study

The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study

Sex Differences in Muscle Wasting

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