Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma

Paterson, Adrienne C.; Macrae, Finlay; Pizzey, Cathy; Baldwin, Graham S.; Shulkes, Arthur

doi:10.1111/jgh.12417

Cited by 10 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22,23 There are recent reports illuminating that an elevated gastrin level promotes CRA tumorigenesis, which could also be seen in our multivariate logistic regression model analysis. 24,25 Considering that Hp stimulates gastrin expression, and that both Hp and gastrin exert the carcinogenic effect of CRA, we therefore hypothesized that Hp might stimulate gastrin expression and then promote tumor progression in CRA patients. However, because the relevant information is still limited, we compared the serum gastrin expression and inter-tumor ki-67 (a well-known biomarker for cancer cell proliferation) expression between Hp + CagA + /Hp + C agA − patients and Hp − patients, and the results disclosed that both of them were increased in Hp + CagA + patients and Hp + CagA − patients compared to Hp − patients, suggesting that Hp might promote CRA progression by advocating gastrin expression, which might be caused by Hp-induced atrophy changes of the gastric body mucosa, leading to increased levels of serum gastrin by negative feedback on antral G cells, and subsequently stimulated tumor cell proliferation of CRA, which caused an elevated ki-67 expression.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma

et al. 2020

View full text Add to dashboard Cite

Objective: This study aimed to investigate the correlation of Helicobacter pylori (Hp) infection with disease risk and severity of colorectal adenoma, also to explore the association of cytotoxin-associated gene A (CagA) positive (CagA+)- Hp infection with gastrin and ki-67 expressions in colorectal adenoma patients. Methods: There were 1000 colorectal adenoma patients and 1500 controls consecutively enrolled, then Hp infection status was determined by 14C urea breath test and rapid urease test. Also, serum CagA expression and gastrin expression of colorectal adenoma patients were determined by enzyme-linked immunosorbent assay. Ki-67 expression in adenoma tissue of colorectal adenoma patients was assessed using immunohistochemistry. Results: Hp+ rate in colorectal adenoma patients (623 (62.3%)) was more elevated than that in controls (814 (54.3%)). Multivariate logistic regression model analysis disclosed that Hp+ was an independent risk factor for colorectal adenoma. Additionally, Hp+ was positively associated with tumor size and high-grade intraepithelial neoplasia in colorectal adenoma patients. Also, serum gastrin expression and intratumoral ki-67 expression were higher in Hp+ CagA+ patients and Hp+ CagA− patients compared to Hp− patients, and they were also higher in Hp+ CagA+ patients compared to Hp+ CagA− patients. Conclusion: Hp infection positively associates with higher disease risk and worse disease conditions of colorectal adenoma, and CagA enhances the carcinogenicity of Hp in colorectal adenoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In addition, progastrin, acting via the CCK2-R, stimulates proliferation in human colonic and gastric cell lines by suppressing bone morphogenetic proteins, members of the transforming growth factor-b superfamily [21]. Compared with controls, patients with a personal or family history of adenomas or colorectal cancer have higher serum concentrations of total gastrin [18]. In colon cancer cells, gastrin stimulates translocation of calcyclin-binding protein/Siah-1 interacting protein (CacyBP/SIP) into the nucleus.…”

Section: Gastrinmentioning

confidence: 96%

Functional anatomy and physiology of gastric secretion

Schubert

2015

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Since it is produced by tumor cells in both the primary tumor and metastasis, it can be used for patient monitoring. Its concentrations in the blood have been found to rise in patients at risk of developing CRC [56]. Progastrin could also be used as a biomarker of liver metastasis in CRC [55].…”

Section: Discussionmentioning

confidence: 99%

“…Plasma assays of hPG80 in CRC patients reveal that the presence of hPG80 correlates with tumor formation. hPG80 concentrations are elevated in patients at risk of developing the disease and in hyperplastic polyps that have proceeded to cancer [11,56].…”

Section: Monitoring Disease Activity and Treatment Efficacymentioning

confidence: 99%

Progastrin: An Overview of Its Crucial Role in the Tumorigenesis of Gastrointestinal Cancers

Fioretzaki,

Sarantis,

Charalampakis

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Defining predictive biomarkers for targeted therapies and optimizing anti-tumor immune response is a main challenge in ongoing investigations. Progastrin has been studied as a potential biomarker for detecting and diagnosing various malignancies, and its secretion has been associated with cell proliferation in the gastrointestinal tract that may promote tumorigenesis. Progastrin is a precursor molecule of gastrin, synthesized as pre-progastrin, converted to progastrin after cleavage, and transformed into amidated gastrin via biosynthetic intermediates. In cancer, progastrin does not maturate in gastrin and becomes a circulating and detectable protein (hPG80). The development of cancer is thought to be dependent on the progressive dysregulation of normal signaling pathways involved in cell proliferation, thus conferring a growth advantage to the cells. Understanding the interaction between progastrin and the immune system is essential for developing future cancer strategies. To that end, the present review will approach the interlink between gastrointestinal cancers and progastrin by exploring the underlying molecular steps involved in the initiation, evolution, and progression of gastrointestinal cancers. Finally, this review will focus on the clinical applications of progastrin and investigate its possible use as a diagnostic and prognostic tumor circulating biomarker for disease progression and treatment effectiveness, as well as its potential role as an innovative cancer target.

show abstract

Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma

Abstract: Concentrations of gastrin precursors are increased in particular groups with an increased risk of developing CRC.

Cited by 10 publications

References 45 publications

Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma

Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma

Functional anatomy and physiology of gastric secretion

Progastrin: An Overview of Its Crucial Role in the Tumorigenesis of Gastrointestinal Cancers

Contact Info

Product

Resources

About