Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients

Crosstalk between Akt and NF‐κB pathway mediates inhibitory effect of gas6 on monocytes‐endothelial cells interactions stimulated by P. gingivalis‐LPS

“…18 Additionally, gas6 has been independently associated with reduced plaque height and total plaque area. 19 Protective effects of Gas6 on endothelial tight junction and permeability were also recently demonstrated in vivo. 20 Together, these data illustrate the critical role of gas6 in inflammation and atherosclerosis, and show that gas6 is likely the base molecule of the mechanisms underlying the association between periodontitis and atherosclerosis.…”

“…In the context of atherosclerosis, Axl and Tyro3 are down‐regulated in advanced human carotid plaques, 17 while Mer mutations promoted the necrosis of atherosclerotic plaques in ApoE ‐/‐ mice 18 . Additionally, gas6 has been independently associated with reduced plaque height and total plaque area 19 . Protective effects of Gas6 on endothelial tight junction and permeability were also recently demonstrated in vivo 20 .…”

Association between plasma growth arrest-specific protein 6 and carotid atherosclerosis in type 2 diabetes mellitus

“…In conclusion, the anti-atherosclerotic effect of Gas6 may be achieved by inhibiting the inflammatory response, anti-apoptosis, eliminating apoptotic cells, and promoting vascular repair. A clinical study by Holden et al [37] found that Gas6 was inversely related to maximum plaque height and total plaque area, and lower Gas6 might be relevant to higher increased AS in males, especially in diabetics. Consistently, we found that Gas6 levels were significantly decreased in AS compared to non-AS in T2DM patients.…”

GAS6/sAXL ratio correlates with National Institutes of Health Stroke Scale (NIHSS) and infarction size in patients with acute ischemic stroke

“…In conclusion, the anti-atherosclerotic effect of GAS6 can be achieved by inhibiting the inflammatory response, anti-apoptosis, eliminating apoptotic cells, and promoting vascular repair. A clinical study by Holden et al 31 found that GAS6 was inversely associated with maximum plaque height and total plaque area, and lower GAS6 may be related to higher increased atherosclerosis in men, particularly diabetics. Also, Fan et al found that subjects with atherosclerosis in diabetes mellitus exhibited low levels of GAS6 and that reduced GAS6 is an independent risk factor for atherosclerosis in diabetes mellitus.…”