“…36,48,[66][67][68] Our work is the first to demonstrate that pFN, synthesized by hepatocytes in liver, contributes to adipogenesis. This adds to the list of tissues (liver, brain, testis, heart, lungs, and bone 37,38 ) and cell types that have been shown to accumulate pFN for their function. 32,33 Furthermore, although FN matrix is clearly an important component of WAT and preadipocyte cultures, its actual function has remained elusive.…”