Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease

Liang, Caihong; Zhang, Lulu; Lian, Xiaoqing; Zhu, Tiantian; Zhang, Yuqing; Gu, Ning

doi:10.1155/2020/9182091

Cited by 21 publications

(12 citation statements)

References 34 publications

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“…Particularly, SOCS2-AS1 was significantly downregulated in HSCR patients. This lncRNA has been described in relation with prostate cancer and retinal Müller cell immune responses and has also been identified as a biomarker in coronary artery disease [67][68][69]. In this sense, SOCS2-AS1 would be a good candidate for further consideration as a gene related to the onset of HSCR and, therefore, of great interest to continue investigating in this line.…”

Section: Discussionmentioning

confidence: 99%

Identification of New Potential LncRNA Biomarkers in Hirschsprung Disease

Torroglosa

Villalba‐Benito

Fernández

et al. 2020

IJMS

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Hirschsprung disease (HSCR) is a neurocristopathy defined by intestinal aganglionosis due to alterations during the development of the Enteric Nervous System (ENS). A wide spectrum of molecules involved in different signaling pathways and mechanisms have been described in HSCR onset. Among them, epigenetic mechanisms are gaining increasing relevance. In an effort to better understand the epigenetic basis of HSCR, we have performed an analysis for the identification of long non-coding RNAs (lncRNAs) by qRT-PCR in enteric precursor cells (EPCs) from controls and HSCR patients. We aimed to test the presence of a set lncRNAs among 84 lncRNAs in human EPCs, which were previously related with crucial cellular processes for ENS development, as well as to identify the possible differences between HSCR patients and controls. As a result, we have determined a set of lncRNAs with positive expression in human EPCs that were screened for mutations using the exome data from our cohort of HSCR patients to identify possible variants related to this pathology. Interestingly, we identified three lncRNAs with different levels of their transcripts (SOCS2-AS, MEG3 and NEAT1) between HSCR patients and controls. We propose such lncRNAs as possible regulatory elements implicated in the onset of HSCR as well as potential biomarkers of this pathology.

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Section: Discussionmentioning

confidence: 99%

Identification of New Potential LncRNA Biomarkers in Hirschsprung Disease

Torroglosa

Villalba‐Benito

Fernández

et al. 2020

IJMS

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“…LncRNAs have been associated with various cardiovascular diseases in the literature, and studies have indicated that be used as a possible biomarker for the early diagnosis of the disease [30][31][32]. At the same time, lncRNAs may have a regulatory role in the pathogenesis of cardiovascular diseases [33].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Decreased Expression Levels of BAT5 and IL21R-AS1 in Circulating Leukocytes of Patients with Acute Myocardial Infarction

Senturk

Karaayvaz

Oksen

et al. 2023

Preprint

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Background: Long non-coding RNAs (lncRNAs) play important roles in cellular processes and disease pathogenesis. In this study, we aimed to show the relationships and possible effects of the expression level of two lncRNAs in acute myocardial infarction (AMI) in circulating leukocytes. Methods and Results: In this case-control study, the relationship between AMI and expression levels of two candidate lncRNAs, called BAT5 (HLA-B-Associated Transcript 5) and IL21R-AS1 (IL21R antisense RNA 1), in 231 patients who underwent percutaneous coronary interventions were investigated. Expression levels of lncRNAs in leukocytes were measured by quantitative real-time PCR (qRT-PCR). The m6A modification regions and subcellular localizations of these lncRNAs were predicted by in silico analysis. Routine biochemical and immunoassay analyzes were performed on Roche Cobas 8000/e701 integrated automated analyzer with their original kits. Ranked ANCOVA tests were used to compare expression levels of lncRNAs between groups after adjusting for gender and use of cardiovascular drugs. The crude and adjusted expression levels of BAT5 and IL21R-AS1 in leukocytes of AMI patients (n=128) were found to decrease compared to the control cases (n=103) (p<0.01 and p<0.05, respectively). In addition, these lncRNAs were negatively correlated with cardiac biomarkers and serum electrolytes in each group (p<0.015). The intracellular functional localization of both lncRNAs is non-nuclear. The number of high confidence m6A modification regions of BAT5 and IL21R-AS1 transcripts was determined as 5 and 4, respectively. Conclusion: This study indicates that the decreased expression levels of BAT5 and IL21R-AS1 are associated with the occurrence of acute myocardial infarction in individuals.

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“…In recent years, some studies have shown that exosomal lncRNAs may provide more stable and accurate lncRNA patterns according to disease subtypes. 9,19,30 Accordingly, enriched and specific lncRNAs in exosomes have gained increasing attention as noninvasive diagnostic biomarkers for cardiovascular diseases, including atherosclerosis (exosomal lncRNA HIF1A-AS1), 31 coronary artery disease (exosomal SOCS2-AS1), 32 and acute myocardial infarction (exosomal lncRNAs ENST00000556899.1 and ENS T00000575985.1). 33 However, the use of serum exosomal lncRNAs to predict and diagnose AF has not been sufficiently reported.…”

Section: Discussionmentioning

confidence: 99%