Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients

Al‐Κafaji, Ghada; Al‐Mahroos, Ghazi; Al‐Muhtaresh, Haifa Abdulla; Sabry, Mohamed; Razzak, Rima Abdul; Salem, Abdel Halim

doi:10.1080/1354750x.2016.1204004

Cited by 50 publications

(39 citation statements)

References 80 publications

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“…MicroRNAs in the peripheral blood are similar to the microRNAs in tissue . Because microRNAs are stable in the peripheral blood, which is easily collected, peripheral blood microRNAs are widely used as diagnosis biomarkers for some diseases, including diabetes‐related diseases . Whether plasma microRNAs can be used as diagnostic biomarkers of GDM, however, is unclear, when GDM is diagnosed at 24–28 weeks of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Plasma microRNA‐16‐5p, ‐17‐5p and ‐20a‐5p: Novel diagnostic biomarkers for gestational diabetes mellitus

Cao¹,

Jia

Xing³

et al. 2017

J of Obstet and Gynaecol

129

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Section: Discussionmentioning

confidence: 99%

Plasma microRNA‐16‐5p, ‐17‐5p and ‐20a‐5p: Novel diagnostic biomarkers for gestational diabetes mellitus

Cao¹,

Jia

Xing³

et al. 2017

J of Obstet and Gynaecol

129

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show abstract

“…Another recent study has shown that circulating endothelium-enriched miR-126 is associated with CAD in DM patients (241). …”

Section: Mirnas In Diabetes Mellitusmentioning

confidence: 99%

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Lucia

Komici²,

Borghetti

et al. 2017

Front. Med.

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Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice.

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“…Coronary artery disease (CAD) is another complication of T2DM, and circulating miR-126 displays differential expression patterns in the plasma of T2DM patients, T2DM patients with CAD, and healthy subjects, suggesting the potential of circulating miR-126 as a biomarker for diabetic CAD [70]. …”

Section: Mirnas As Type 2 Diabetes (T2dm) Markers and Its Complicamentioning

confidence: 99%

Regulatory Roles of MicroRNAs in Diabetes

Feng

Xing

Xie

2016

IJMS

122

100

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MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.

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Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients

Cited by 50 publications

References 80 publications

Plasma microRNA‐16‐5p, ‐17‐5p and ‐20a‐5p: Novel diagnostic biomarkers for gestational diabetes mellitus

Plasma microRNA‐16‐5p, ‐17‐5p and ‐20a‐5p: Novel diagnostic biomarkers for gestational diabetes mellitus

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Regulatory Roles of MicroRNAs in Diabetes

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