Circulating Endothelial Progenitor Cells Are Inversely Associated with Organ Dysfunction in Sepsis.

Cribbs, S.K.; Sutcliffe, DJ; Wr, Taylor; Rojas, Mauricio; Kl, Brigham; Easley, K; Tang, Ling; Martin, G S

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4711

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Centrally, SDF-1α can autoregulate AVP release through its receptor (CXCR4) [ 12 , 40 ]. Systemically, SDF-1α is released in bloodstream early after critical illness initiation, and is associated with endothelial progenitor cell mobilization, sepsis-induced organ dysfunctions [ 41 , 42 ]. Indeed, in this study, blood SDF-1α discriminated sepsis, as well as sepsis severity and outcome.…”

Section: Discussionmentioning

confidence: 99%

Proven infection-related sepsis induces a differential stress response early after ICU admission

et al. 2010

View full text Add to dashboard Cite

IntroductionNeuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis observed in septic ICU patients. Study aims were: (i) to portray a distinctive stress-related neuro-corticotropic systemic profile of early sepsis, (ii) to propose a combination data score, for aiding ICU physicians in diagnosing sepsis on admission.MethodsThis prospective one-center observational study was carried out in a medical intensive care unit (MICU), tertiary teaching hospital. Seventy-four out of 112 critically ill patients exhibiting systemic inflammatory response syndrome (SIRS) were divided into two groups: proven sepsis and non sepsis, based on post hoc analysis of microbiological criteria and final diagnosis, and compared to healthy volunteers (n = 14). A single blood sampling was performed on admission for measurements of AVP, copeptin, APL, SDF-1α, adrenocorticotropic hormone (ACTH), cortisol baseline and post-stimulation, and procalcitonin (PCT).ResultsBlood baseline ACTH/cortisol ratio was lower and copeptin higher in septic vs. nonseptic patients. SDF-1α was further increased in septic patients vs. normal patients. Cortisol baseline, ACTH, PCT, APACHE II and sepsis scores, and shock on admission, were independent predictors of sepsis diagnosis upon admission. Using the three first aforementioned categorical bio-parameters, a probability score for predicting sepsis yielded an area under the Receiver Operating Curve (ROC) curves better than sepsis score or PCT alone (0.903 vs 0.727 and 0.726: P = 0.005 and P < 0.04, respectively).ConclusionsThe stress response of early admitted ICU patients is different in septic vs. non-septic conditions. A proposed combination of variable score analyses will tentatively help in refining bedside diagnostic tools to efficiently diagnose sepsis after further validation.

show abstract