Circulating Endothelial Cells for Evaluation of Tumor Response in Non-Small Cell lung cancer patients receiving first-line chemotherapy

Najjar, Fadi; Al-Massarani, Ghassan; I, Banat; Alammar, Moosheer

doi:10.5301/jbm.5000154

Cited by 1 publication

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References 45 publications

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“…CD146 is a cell adhesion molecule mainly expressed on epithelial cell surface. CD146 plays an important role in tumorigenesis and development, and has been recognized as a biomarker of various malignant tumor metastasis [13,14]. In addition, CD146 antibody could inhibit tumor, indicating that CD146 is a target for cancer therapy [15,16].…”

Section: Discussionmentioning

confidence: 99%

PTEN and CD146 expression in endometrioid adenocarcinoma

2020

EJGO

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Objective: Endometrioid adenocarcinoma is the most common pathological type of endometrial carcinoma. This study aimed to examine the expression of PTEN and CD146 in endometrioid adenocarcinoma, and to investigate their relationship with clinical characteristics of endometrioid adenocarcinoma. Materials and Methods: The expression of PTEN and CD146 in 126 specimens of endometrioid adenocarcinoma was detected by immunohistochemical technique, and the correlation of their expression with clinical parameters of the patients was analyzed. Results: PTEN expression in endometrioid adenocarcinoma group was lower than that in endometrial hyperplasia group and endometrial polyp group, while CD146 expression in endometrioid adenocarcinoma group was higher than that in endometrial hyperplasia group and endometrial polyp group (p < 0.05). High expression of CD146 was associated with his tological grade and depth of invasion of endometrioid adenocarcinoma, but there was no correlation between PTEN expression and clinical parameters. Conclusions: CD146 and PTEN may be promising biomarkers and targets for the diagnosis and treatment of endometrioid adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

PTEN and CD146 expression in endometrioid adenocarcinoma

2020

EJGO

View full text Add to dashboard Cite

show abstract

Circulating Endothelial Cells for Evaluation of Tumor Response in Non-Small Cell lung cancer patients receiving first-line chemotherapy

Cited by 1 publication

References 45 publications

PTEN and CD146 expression in endometrioid adenocarcinoma

PTEN and CD146 expression in endometrioid adenocarcinoma

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