Circulating D-Dimers Increase the Risk of Mortality and Venous Thromboembolism in Patients With Lung Cancer: A Systematic Analysis Combined With External Validation

Li, Jing; Yan, Shanle; Zhang, Xiaohui; Xiang, Mengqi; Zhang, Chuanhua; Gu, Ling; Wei, Xiaoying; You, Chuanyun; Chen, Shenhua; Zeng, Daxiong; Jiang, Jian‐Hua

doi:10.3389/fmed.2022.853941

Cited by 7 publications

(10 citation statements)

References 51 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study VTE showed a statistically significant association with high D dimer (ng/ml), sPselectin (ng/ml), Khorana score, and Vienna CATS score. This is in similarity to Li et al (22) who reported that VTE showed a statistically significant association with high D dimer (P<0.05), but contrary to Hayashida et al (23) who found that D-dimer levels were not associated with VTE in the multivariate analysis, likely because they are affected by many risk factors, such as cancer and aging.…”

supporting

confidence: 86%

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

El-sayed

Ebrahim²,

Ghoneim³

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: Modern oncology has a compelling problem in predicting the hazards of venous thromboembolism (VTE) linked with chemotherapy. Although thromboprophylaxis is not now advised for primary prevention, it is typically advised that cases' risks of VTE be evaluated before treatment. Great interest was given to establishing effective predictive methods for VTE in cancer cases. The aim of this study:The study aimed to detect whether Egyptian cancer cases' VTE risk could be predicted using the modified Vienna Cancer and Thrombosis Study (CATS) score. Methods: 214 newly diagnosed cancer cases participated in a prospective cohort study completed before receiving chemotherapy. Cases who received chemotherapy were monitored for VTE episodes for six months. The Khorana score was determined. D dimer and soluble P-selectin (sP-selectin) levels were assessed, followed by a modified Vienna CATS score. For each example, the Vienna CATS score was determined. Results: Only 24 (11.2%) of the 214 cases who had follow-up experienced VTE episodes, and 5 of these (2.3%) were lost. Conclusion:When compared to the Khorana score, the modified Vienna CATS score was more sensitive in identifying cancer cases at risk for VTE. Implementation of modified Vienna CATS in the clinical workup of cancer cases could help physicians to tailor antithrombotic therapy and lead to the perfect use of thromboprophylaxis.

show abstract

supporting

confidence: 86%

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

El-sayed

Ebrahim²,

Ghoneim³

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…According to the results of the meta-analyses carried out by Jean-François Llitjos et al and Li J et al, high D-dimer was found to be a major risk factor for DVT and that patients at high risk of DVT are more likely to be admitted to the intensive care unit [40,41]. This could be due to a syndrome of systemic inflammatory response to activation of blood coagulation, defined as a high level of fibrinogen.…”

Section: Discussionmentioning

confidence: 99%

Assessment of risk factors for thrombosis in ICU patients with COVID-19

2023

View full text Add to dashboard Cite

Introduction: High incidence of thrombotic events has been reported in hospitalized patients with COVID-19. Less than 50% of pulmonary embolisms (PE) are associated with signs of deep vein thrombosis (DVT) of the lower extremities. Objective: To assess the risk factors of deep vein thrombosis (DVT) in intensive care patients with COVID-19 by comparing the clinical features of patients in groups with thrombosis, venous stasis and without deep vein thrombosis. Material and methods: A prospective cross-sectional study was conducted that included all consecutive adult patients with laboratory-confirmed COVID-19 admitted to the intensive care unit. We investigated chronic comorbid conditions in patients, including arterial hypertension, diabetes mellitus, obesity, chronic kidney failure (CRF), chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), and cancer which may be a risk factor for thrombosis. Results: A total of 465 patients were included in the study. Comorbidities were present in 435 of 465 patients (93.55%). Doppler ultrasound (DUS) confirmed deep vein thrombosis in 60 patients (13.8%), which was associated with older age (71.12±13.98 vs. (79.57%), chronic heart failure - 196 (42.15%), obesity - 161 (34.62%), diabetes mellitus - 144 (30.97%), chronic renal failure (CRF) -58 (12.47%) and oncological diseases - 25 (5.38%). Hypertension (p=0.02), diabetes mellitus (p=0.041) and obesity (p=0.01) were significant risk factors for DVT. D-dimer was a statistically significant predictor of DVT formation (p<0.001), an increase in D-dimer per unit increased the risk of DVT by 14%. Conclusion: The study identified risk factors for deep vein thrombosis in intensive care patients with COVID-19. These include: age, high levels of D-dimer, and comorbidities such as hypertension, obesity, and diabetes mellitus.

show abstract

“…In some studies, although D-dimer has been reported as a prognostic indicator for patients with PC, its clinical application remains controversial due to the limited size of the studies and the lack of adjustment for risk factors 11 . In these meta-analyses, D-dimer has been shown to predict poor prognosis in lung, breast and gastric cancers [37][38][39] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the association between D-dimer levels and clinicopathological characteristics of pancreatic cancer and its role in prognosis: a systematic review and meta-analysis

Wu¹,

Zhang²,

Zhao³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: According to previous studies, D-dimer levels are associated with prognosis in patients with pancreatic cancer (PC). However, the current results are limited and controversial. Therefore, we conducted this meta-analysis to assess the relationship between D-dimer levels and the prognosis and pathological characteristics of patients with PC. Method: A computer search of PubMed, Embase, The Cochrane Library, Web Of Science, CBM, VIP, CNKI and Wanfang databases was conducted to identify available studies. The association between pre-treatment d -dimer levels and the prognosis of PC patients was assessed using a combined hazard ratio (HR) and 95% confidence interval (CI). The combined odds ratio (OR) and 95% confidence in CI were applied to assess the relationship between D-dimer levels and the pathological characteristics of patients with PC. For all of the statistical analyses, Stata 12.0 software was used. Result: A total of 13 studies involving 2777 patients were included in this meta-analysis. The results showed that elevated pre-treatment d -dimer levels were significantly associated with worsening OS (HR = 1.46 95% CI: 1.34-1.59; p＜0.001). We also performed subgroup analyses based on sample size, d -dimer threshold, follow-up time and source of HR to further validate the prognostic value of pre-treatment d -dimer levels in PC. In addition, according to the analysis, high pre-treatment d -dimer levels in PC patients were associated with late tumour stage (OR = 4.78, 95% CI 1.73-13.20, p＜0.005), larger tumours (OR = 1.72, 95% CI 1.25 ~ 2.35, p＜0.005) and distant metastases in tumours (OR = 5.06, 95% CI 2.45- 10.43, p＜0.005) were significantly associated. In contrast, other clinicopathological factors, including age, sex and lymph node metastasis, were not associated with d -dimer levels. Conclusion: High levels of d-dimer prior to treatment are associated with poor prognosis in patients with PC and are associated with more advanced tumour stage, larger tumours and the occurrence of distant metastases. Plasma d-dimer levels can be used as a biomarker of prognosis in patients with PC.

show abstract

Circulating D-Dimers Increase the Risk of Mortality and Venous Thromboembolism in Patients With Lung Cancer: A Systematic Analysis Combined With External Validation

Cited by 7 publications

References 51 publications

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

Assessment of risk factors for thrombosis in ICU patients with COVID-19

Assessment of the association between D-dimer levels and clinicopathological characteristics of pancreatic cancer and its role in prognosis: a systematic review and meta-analysis

Contact Info

Product

Resources

About