Circulating cytokine-producing VP6-specific CD4+ T cells are rarely detectable in Rotarix -vaccinated Malawian children with severe rotavirus diarrhoea
Abstract:Strong CD4+ T cell-mediated immune protection following rotavirus infection has been observed in animal models, but its relevance in humans remains unclear. Here, we characterized acute and convalescent CD4+ T cell responses in Rotarix®-vaccinated children who were hospitalized with rotavirus-positive and rotavirus-negative diarrhoea in Blantyre, Malawi. Children presenting with laboratory-confirmed rotavirus infection had higher proportions of effector and central memory T helper 2 cells during acute infectio… Show more
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