Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study

Abstract

Aims CTRP6, a newly discovered adipokine, has been found to be a regulator for energy homeostasis. However, the association between circulating CTRP6 and obesity in humans is still unclear. Methods 256 individuals, including 185 overweight/obese (OW/OB) and 71 normal weight adults, were recruited for this study. Circulating concentrations of CTRP6 and adiponectin (Adipoq) were examined by ELISA. Results Serum CTRP6 levels in obese individuals were significantly increased compared with those in healthy individuals (506.1±134.9 vs.363.3±80.5 ng/mL, P<0.01). Conversely, serum Adipoq concentrations in OW/OB individuals were markedly decreased compared with healthy controls [20.8 (12.1–29.3) vs. 14.1 ( 8.61–17.7) ; P<0.01]. Correlation analysis revealed that there was a positive relationship between circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c, but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis revealed that high serum CTRP6 levels are markedly associated with OW/OB. Finally, ROC curve analysis showed that the cut-off value for serum CTRP6 for prediction of IR is 518 ng/mL. Conclusions CTRP6 may be a marker related to OW/OB.

Circulating levels of C1q/TNF‐α‐related protein 6 (CTRP6) in polycystic ovary syndrome

“…Conversely, in the present study, we found that high serum levels of CTRP6 inversely correlated with metabolic disturbances in PCOS individuals, when compared with healthy controls, exhibiting a strong independent association with adiponectin. Low levels of adiponectin, CTRP3 and CTRP5 on one hand, and high levels of CTRP6 and CTRP15 on the other, have been witnessed in individuals diagnosed with insulin resistance, metabolic syndrome, and T2DM . In this study, we have demonstrated that CTRP6 levels positively correlated with markers related to FBG, but not insulin resistance.…”

“…However, in one study, CTRP6 levels were positively associated with FBG, fasting insulin, glycated hemoglobin (HbA1c), and HOMA‐IR in prediabetic and T2DM Chinese patients . Recently, Liao et al found a direct correlation with the same parameters in overweight/obese Chinese subjects with a cutoff of 518 ng/ml of CTRP6 predicting insulin resistance . The variation in results might be due to the difference in sample size and population.…”

“…This comes in accordance with previous studies. For instance, Liao et al found that serum levels of CTRP6 were strongly associated with obesity markers (BMI, % body fat, waist‐to‐hip ratio [WHR]), and lipid profile [TG, TC, and HDL‐C]) . Lei et al also found a significant upregulation in CTRP6 expression in the visceral and subcutaneous fat of obese subjects, when compared with lean controls .…”

Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome

“…This study was performed from December 2018 to September 2019. One hundred and twenty-two women with PCOS (PCOS group, 19-37 years old) and eighty-five normal controls (N group, [19][20][21][22][23][24][25][26][27][28][29][30][31][32] years old) participated in the current study. The diagnosis of PCOS was based on the Rotterdam consensus criterion, which met two of the following three criteria [25]…”

“…Blood glucose, HbA1c, insulin levels, and blood fat, including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured as in a previous population [28].The electrochemiluminescence immunoassay was performed for measuring serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) by using COBASE immunoassay analyzers (Roche Diagnostics GmbH). An automated analyzer was used for measuring dehydroepiandrostenedione sulfate (DHEA-S) [29].…”