Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy

El-Shebini, Salwa M.; Ghattas, Lobna A.; Hamed, Ibrahim; Moaty, Maha I. A.; Tapozada, Salwa T.; Hanna, Laila M.

doi:10.3923/jms.2009.219.226

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Further support comes from human clinical studies, in which El-Shebini et al . found that indices of leptin resistance are improved by replacing bread with vegetables in otherwise similar hypocaloric diets and with similar weight loss [ 8 ]. Another study by Ryberg et al .…”

Section: Introductionmentioning

confidence: 99%

Digested wheat gluten inhibits binding between leptin and its receptor

et al. 2015

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BackgroundLeptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. Non-degraded dietary wheat protein has been found in human serum at a mean level of 41 ng/mL. Here, we report our findings from testing whether enzymatically digested gluten from wheat prevents leptin from binding to the leptin receptor in vitro.Gluten from wheat was digested with pepsin and trypsin under physiological conditions. Pepsin and trypsin activity was removed from the gluten digest with a 10 kDa spin-filter or by heat treatment at 100°C for 30 min. Binding to the leptin receptor of leptin mixed with gluten digest at a series of concentrations was measured using surface plasmon resonance technology.ResultsBinding of the gluten digest to the leptin receptor was not detected. Spin-filtered gluten digest inhibited binding of leptin to the leptin receptor, with 50% inhibition at a gluten digest concentration of ~10 ng/mL. Heat-treated gluten digest did not inhibit leptin binding.ConclusionsDigested wheat gluten inhibits binding of leptin to the leptin receptor, with half-maximal inhibition at 10 ng/mL. The inhibition is significant at clinically relevant concentrations and could therefore serve as a novel pathway to investigate to understand the molecular basis of leptin resistance, obesity and associated disorders.

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Section: Introductionmentioning

confidence: 99%

Digested wheat gluten inhibits binding between leptin and its receptor

et al. 2015

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Association between multimeric adiponectin and free leptin index with atherogenic dyslipidemia in non-diabetic obese men

Ninghayu¹,

Wijaya²,

As’ad³

2011

Med J Indones

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Latar belakang: Penelitian ini bertujuan menilai peran berbagai adiponektin dan indeks leptin bebas terhadap dislipidemia aterogenik pada pria obesitas sentral non diabetes. Metode: Desain penelitian ini adalah potong lintang pada 120 pria obesitas sentral non-diabetes yang dilakukan di Jakarta. Parameter yang diukur adalah adiponektin total, adiponektin berat molekul tinggi, adiponektin berat molekul sedang, adiponektin berat molekul rendah, leptin, soluble leptin receptor, trigliserida, kolesterol HDL, kolesterol LDL dan apolipoprotein B (Apo B). Kriteria dislipidemia aterogenik adalah rendahnya kadar kolesterol HDL, disertai trigliserida dan small dense LDL (sdLDL) yang tinggi. Kadar sdLDL didapat dari rasio kolesterol LDL / Apo B. Indeks leptin bebas adalah rasio leptin dengan soluble leptin receptor dengan menggunakan median sebagai titik dikotomi. Dilakukan krostabulasi untuk data kategorial. Hubungan antara adiponektin multimerik, indeks leptin bebas dengan lipid aterogenik dianalisis dengan uji Spearman, selanjutnya hasil interaksi keseluruhan parameter terhadap dislipidemia aterogenik dianalisis dengan regresi logistik ganda. Hasil: Adiponektin berat molekul tinggi berkorelasi negatif secara bermakna dengan dislipidemia aterogenik (p< 0,05), sedangkan adiponektin berat molekul sedang dan adiponektin berat molekul rendah tidak berkorelasi (p> 0,05) dengan dislipidemia aterogenik. Indeks leptin bebas berkorelasi positif secara bermakna dengan dislipidemia aterogenik (p< 0,05). Odds Rasio (OR) adiponektin berat molekul tinggi terhadap kejadian dislipidemia aterogenik adalah 3,62 (p< 0,05), sedangkan risiko dislipidemia aterogenik pada subyek dengan indeks leptin bebas rendah adalah 4,57 (p< 0,05).

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Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy

Cited by 2 publications

References 34 publications

Digested wheat gluten inhibits binding between leptin and its receptor

Digested wheat gluten inhibits binding between leptin and its receptor

Association between multimeric adiponectin and free leptin index with atherogenic dyslipidemia in non-diabetic obese men

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