Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Hankinson, Susan E.; Willett, Walter C.; Colditz, Graham A.; Hunter, David J.; Michaud, Dominique S.; Deroo, Bonnie J.; Rosner, Bernard; Speizer, Frank E.; Pollak, Michael

doi:10.1016/s0140-6736(97)10384-1

Cited by 1,657 publications

(997 citation statements)

References 26 publications

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“…In a small case -control study IGF-1 and IGFBP-3 were found, respectively, directly and indirectly associated with premenopausal ductal carcinoma in situ (Bohlke et al, 1998). Similar results were obtained in a nested case -control study based on the American Nurses Cohort where the positive association between plasma IGF-1 levels and breast cancer risk reached significance in premenopausal women younger than 50 and the relative risk increased after adjustment for plasma IGFBP-3 concentrations (Hankinson et al, 1998). Most of these studies did not include analysis on free IGF-1 which may be the most active fraction of total IGF-1, except in one small case-control study (Li et al, 2001) where a significant positive association was found with breast cancer risk (OR ¼ 6.31).…”

Section: Glycemic Index In Chronic Disease Ls Augustin Et Alsupporting

confidence: 74%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Section: Glycemic Index In Chronic Disease Ls Augustin Et Alsupporting

confidence: 74%

Glycemic index in chronic disease: a review

et al. 2002

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“…We have found in previous work, using immunohistochemistry in breast biopsies, that the area of tissue stained for IGF-I is associated with mammographic density in women under the age of 50, but not in older women (Guo et al, 2001). It has also been shown in a cohort study, carried out in the NHS, that higher blood levels of IGF-I were related to the subsequent development of breast cancer in premenopausal but not postmenopausal women (Hankinson et al, 1998). A further study in the NHS found higher blood levels of prolactin to be associated with an increased risk of breast cancer in postmenopausal, but not in premenopausal women (Hankinson et al, 1999).…”

Section: Discussionmentioning

confidence: 90%

The association of breast mitogens with mammographic densities

et al. 2002

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Radiologically dense breast tissue (mammographic density) is strongly associated with risk of breast cancer, but the biological basis for this association is unknown. In this study we have examined the association of circulating levels of hormones and growth factors with mammographic density. A total of 382 subjects, 193 premenopausal and 189 postmenopausal, without previous breast cancer or current hormone use, were selected in each of five categories of breast density from mammography units. Risk factor information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured. Mammograms were digitised and measured using a computer-assisted method. After adjustment for other risk factors, we found in premenopausal women that serum insulin-like growth factor-I levels, and in postmenopausal women, serum levels of prolactin, were both significantly and positively associated with per cent density. Total oestradiol and progesterone levels were unrelated to per cent density in both groups. In postmenopausal women, free oestradiol (negatively), and sex hormone binding globulin (positively), were significantly related to per cent density. These data show an association between blood levels of breast mitogens and mammographic density, and suggest a biological basis for the associated risk of breast cancer.

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“…Furthermore, epidemiological prospective studies have identified high plasma levels of IGF-1 as a potential risk factor for several malignancies (Hankinson et al, 1998). In addition, IGF-2, whose expression normally is strictly controlled by parental imprinting is upregulated and functions as an important stimulant of the IGF-1R in cancer (LeRoith and Roberts, 2003).…”

Section: Unique Role Of Igf-1r In Cancermentioning

confidence: 99%

Role of insulin-like growth factor 1 receptor signalling in cancer

2005

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The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth. This is in part due to the interactions with oncogenes. Recent findings suggest a close interplay with the p53/MDM2 pathway. Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell. Targeting of IGF-1R is more and more seen as a promising option for future cancer therapy. Single chain antibodies and small molecules with selective effects on IGF-1R dependent malignant growth are of particular interest. Forthcoming clinical trials are welcome and will indeed be the only way to evaluate the impact of IGF-1R targeting in human cancer.

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Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Cited by 1,657 publications

References 26 publications

Glycemic index in chronic disease: a review

Glycemic index in chronic disease: a review

The association of breast mitogens with mammographic densities

Role of insulin-like growth factor 1 receptor signalling in cancer

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