Circulating Concentrations of Advanced Glycation end Products, its Association With the Development of Diabetes Mellitus

Jiménez, Itzel Uribe; Díaz-Díaz, Eulises; Castro, Jorge Salmerón; Ramos, Julieta; León, Mario Cárdenas; Rı́os, José; Bautista, Juan; Correa‐Rotter, Ricardo; Aguilar-Salinas, Carlos; Larrea, Fernando

doi:10.1016/j.arcmed.2017.07.001

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Such observations suggest a link with early stages of metabolic dysregulation such as prediabetes and avoiding the classical idea of glycosative stress being a consequence of chronic hyperglycemia [73,75]. Such a relation was also detailed by Jiménez et al (2017), who have observed increased probability of developing prediabetes or type 2 diabetes according to the progressively higher serum AGEs levels seven years earlier [76]. In another study in children with obesity, insulin resistance was associated with increased CML levels and lower antioxidant activity [77].…”

Section: Evidence In Human Studiesmentioning

confidence: 88%

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Matafome

2020

Diabetology

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The term glycotoxins includes the group of advanced glycation end-products (AGEs) and their precursors, most of them highly reactive intermediary compounds, such as methylglyoxal (MG). Glycotoxins were initially thought to participate in the development of diabetic complications because of their increased formation from glucose. However, they also form and accumulate in tissues since the early stages of disease, such as metabolically unhealthy obesity and prediabetes. Such accumulation has been suggested to result from dysregulated activity of detoxification systems, such as the glyoxalase system, as well as increased dietary consumption, namely from high-glucose and high-fructose foods processed at high temperatures. Although some studies may have used supraphysiological doses, in vitro systems and animal models have shown glycotoxin-induced insulin resistance. Moreover, dietary glycotoxin restriction was shown to improve insulin resistance in humans and glyoxalase (GLO)-1 upregulation improved insulin sensitivity and metabolic function. This review summarizes the current knowledge about glycotoxin involvement in the development of insulin resistance, the mechanisms involved and the usefulness of GLO-1 modulation, and a possible therapeutic strategy to improve insulin sensitivity.

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Section: Evidence In Human Studiesmentioning

confidence: 88%

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Matafome

2020

Diabetology

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“…Secondly, we have also observed that both groups of patients with intermediate and high AGEs levels had a higher prevalence of diabetes-related complications. Several data have linked circulating AGEs to the development and progression of diabetes complications [35][36][37] including diabetic retinopathy [38][39][40][41], nephropathy [42,43], and cardiovascular disease [44][45][46]. Furthermore, an accumulation of AGEs has been detected in most of target tissues of diabetes complications, such as the kidney, retina, and atherosclerotic plaques [47].…”

Section: Discussionmentioning

confidence: 99%

Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Sanchís

Rivera

Fortuny

et al. 2020

JCM

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The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications.

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“…Inc., MI, USA). Advanced glycosylation products (AGEs) concentrations were determined according to a method previously described by Jiménez et al [17]. The HOMA index of resistance to insulin was calculated.…”

Section: Methodsmentioning

confidence: 99%

Intra-Abdominal Fat Adipocyte Hypertrophy through a Progressive Alteration of Lipolysis and Lipogenesis in Metabolic Syndrome Rats

et al. 2019

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This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) rat model caused by chronic consumption of 30% sucrose in drinking water. A total of 70 male Wistar rats were divided into two groups: C and MS. Each of these groups were then subdivided into five groups which were sacrificed as paired groups every month from the beginning of the treatment until 5 months. The intra-abdominal fat was dissected, and the adipocytes were extracted. Lipoprotein lipase (LPL), hormone-sensitive lipase (HSL), protein kinases A (PKA), and perilipin A expressions were determined. The LPL and HSL activities were evaluated by spectrophotometry. Histological staining was performed in adipose tissue. Significant increases were observed in blood pressure, HOMA-IR, leptin, triglycerides, insulin, intra-abdominal fat, and number of fat cells per field (p = 0.001) and in advanced glycosylation products, adipocyte area, LPL, HSL activities and/or expression (p ≤ 0.01) in the MS groups progressively from the third month onward. Lipogenesis and lipolysis were increased by LPL activity and HSL activity and/or expression. This was associated with hyperinsulinemia and release of non-esterified fatty acids causing a positive feedback loop that contributes to the development of adipocyte hypertrophy.

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Circulating Concentrations of Advanced Glycation end Products, its Association With the Development of Diabetes Mellitus

Cited by 15 publications

References 32 publications

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Intra-Abdominal Fat Adipocyte Hypertrophy through a Progressive Alteration of Lipolysis and Lipogenesis in Metabolic Syndrome Rats

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