Circulating concentration of interleukin-37 in Helicobacter pylori-infected patients with peptic ulcer: Its association with IL-37 related gene polymorphisms and bacterial virulence factor CagA

Davarpanah, Elham; Jafarzadeh, Abdollah; Nemati, Maryam; Bassagh, Arezoo; Abasi, Mehdi Hayatbakhsh; Khosravimashizi, Arezu; Kazemipoor, Nadia; Ghazizadeh, Motahareh; Mirzaee, Moghaddameh

doi:10.1016/j.cyto.2019.154928

Cited by 16 publications

(17 citation statements)

References 36 publications

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“…Only one of the studies included in our analysis investigated associations between gender and IL-37 levels in healthy subjects, showing no significant differences in serum IL-37 levels according to gender (35). Davarpanah et al (76) (excluded study) reported the same findings. In light of the limited number of studies, a larger and independent healthy population study is warranted.…”

Section: Discussionsupporting

confidence: 51%

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Santarelli¹,

Vincent

Rudloff

et al. 2021

Front. Immunol.

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Interleukin (IL)-37 has an important function in limiting excessive inflammation. Its expression is increased in numerous inflammatory and autoimmune conditions and correlates with disease activity, suggesting it could have potential as a disease biomarker. Nevertheless, a reference range has yet to be determined. Our aim was to establish the first reference range of circulating IL-37 levels in healthy adult humans. PubMed was searched for studies reporting blood IL-37 concentrations in healthy adult subjects as measured by enzyme-linked immunosorbent assay. Nineteen studies were included in the analysis. Mean IL-37 levels were weighted by sample sizes, and weighted mean lower and upper levels ( ± 2SD of means) were calculated to provide a weighted mean and reference range. IL-37 levels were quantified in either serum or plasma from a total of 1035 (647 serum; 388 plasma) healthy subjects. The serum, plasma and combined matrix weighted means (reference ranges) were 72.9 (41.5 – 104.4) pg/mL, 83.9 (41.1 – 126.8) pg/mL, and 77.1 (41.4 – 112.8) pg/mL, respectively. There were no significant differences between serum and plasma means and upper and lower limits. Study means and upper IL-37 levels were significantly higher in Chinese population studies. From our analysis, a preliminary reference range for circulating IL-37 levels in healthy human adults has been established. In order to determine a reliable reference range for clinical application, large, prospective, multi-ethnic, healthy population studies are necessary. In addition, demographics, sample matrix, collection, processing and storage methods potentially affecting IL-37 detection levels should be thoroughly investigated.

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Section: Discussionsupporting

confidence: 51%

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Santarelli¹,

Vincent

Rudloff

et al. 2021

Front. Immunol.

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“…The association of the vaccine-induced autoimmunity and human leukocyte antigen (HLA) gene has been also indicated. Furthermore, genetic polymorphisms in the cytokine genes may cause overexpression of cytokines and hyper-inflammatory responses, resulting in unfavorable consequences [ 86 , 95 , 96 ].…”

Section: Mechanisms Of Covid-19 Vaccination-induced Thyroid Dysfunctionsmentioning

confidence: 99%

Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence

Jafarzadeh

Nemati

Jafarzadeh

et al. 2022

J Endocrinol Invest

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Purpose The safety and efficacy of the several types of COVID-19 vaccines, including mRNA-based, viral vector-based, and inactivated vaccines, have been approved by WHO. The vaccines can confer protection against severe SARS-CoV-2 infection through induction of the anti-spike protein neutralizing antibodies. However, SARS-CoV-2 vaccines have been associated with very rare complications, such as thyroid disorders. This review was conducted to highlight main features of thyroid abnormalities following COVID-19 vaccination. Methods A comprehensive search within electronic databases was performed to collect reports of thyroid disorders after vaccination with COVID-19 vaccines. Results Among 83 reported cases including in this review, the most cases of thyroid abnormalities were observed after vaccination with mRNA-based vaccines (68.7%), followed by viral vector vaccines (15.7%) and 14.5% cases following inactivated vaccines. Subacute thyroiditis (SAT) was the most common COVID-19 vaccination-related thyroid disease, accounting for 60.2% of all cases, followed by Graves' disease (GD) with 25.3%. Moreover, some cases with focal painful thyroiditis (3.6%), silent thyroiditis (3.6%), concurrent GD and SAT (2.4%), thyroid eye disease (1.2%), overt hypothyroidism (1.2%), atypical subacute thyroiditis (1.2%), and painless thyroiditis with TPP (1.2%) were also reported. Overall, in 58.0% of SAT cases and in 61.9% of GD cases, the onset of the symptoms occurred following the first vaccine dose with a median of 10.0 days (ranged: 3–21 days) and 10.0 days (ranged: 1–60 days) after vaccination, respectively. Moreover, 40.0% of SAT patients and 38.1% of GD patients developed the symptoms after the second dose with a median of 10.5 days (ranged: 0.5–37 days) and 14.0 days (ranged: 2–35 days) after vaccination, respectively. Conclusion Fortunately, almost all cases with COVID-19 vaccination-associated thyroid dysfunctions had a favorable outcome following therapy. The benefits of COVID-19 vaccinations in terms of terminating the pandemic and/or reducing mortality rates can exceed any risk of infrequent complications such as a transient thyroid malfunction.

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“…Moreover, in patients with arterial hypertension, alterations in IL-12, IL-23, IL-27, IL-35, and IL-37 concentrations are connected with the development of carotid atherosclerotic plaque [157,158]. All aforementioned cytokines are also associated with H. pylori infection [159][160][161][162].…”

Section: H Pylori-related Mets Parameters and Arterial Hypertensionmentioning

confidence: 99%

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

et al. 2021

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Arterial hypertension is a risk factor for several pathologies, mainly including cardio-cerebrovascular diseases, which rank as leading causes of morbidity and mortality worldwide. Arterial hypertension also constitutes a fundamental component of the metabolic syndrome. Helicobacter pylori infection is one of the most common types of chronic infection globally and displays a plethora of both gastric and extragastric effects. Among other entities, Helicobacter pylori has been implicated in the pathogenesis of the metabolic syndrome. Within this review, we illustrate the current state-of-the-art evidence, which may link several components of the Helicobacter pylori-related metabolic syndrome, including non-alcoholic fatty liver disease and arterial hypertension. In particular, current knowledge of how Helicobacter pylori exerts its virulence through dietary, inflammatory and metabolic pathways will be discussed. Although there is still no causative link between these entities, the emerging evidence from both basic and clinical research supports the proposal that several components of the Helicobacter pylori infection-related metabolic syndrome present an important risk factor in the development of arterial hypertension. The triad of Helicobacter pylori infection, the metabolic syndrome, and hypertension represents a crucial worldwide health problem on a pandemic scale with high morbidity and mortality, like COVID-19, thereby requiring awareness and appropriate management on a global scale.

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Circulating concentration of interleukin-37 in Helicobacter pylori-infected patients with peptic ulcer: Its association with IL-37 related gene polymorphisms and bacterial virulence factor CagA

Cited by 16 publications

References 36 publications

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

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