Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection

Yin, Weibing; Yan, Mingguang; Xiao, Fang; Guo, Jianjun; Xiong, Wei; Zhang, Ruo-Peng

doi:10.1016/j.cca.2017.10.011

Cited by 143 publications

(112 citation statements)

References 26 publications

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“…Hsa_circ_0001785 and hsa_circ_0108942 were remarkably upregulated, while hsa_circ_0068033 was downregulated. Additional studies revealed that the hsa_circ_0068033 expression rate was strongly related to histological grade, tumor‐node‐metastasis stage, and distant metastasis in patients with BC (Yin et al, 2017). circRNA profile was investigated explicitly in patients with TNBC.…”

Section: Resultsmentioning

confidence: 99%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell‐type and stage‐specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.

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Section: Resultsmentioning

confidence: 99%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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“…For example, Zhao et al [15]. discovered that peripheral blood hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease and Yin et al [16]. reported that plasma hsa_circ_0001785 can serve as a diagnostic biomarker for breast cancer detection.…”

Section: Introductionmentioning

confidence: 99%

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Zhao

Wang

Ouyang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent studies have demonstrated that circular RNAs (circRNAs) can serve as potential molecular markers for disease diagnosis. However, little is known about their diagnostic potential for oral squamous cell carcinoma (OSCC). This study aimed to determine the expression of circRNAs in the saliva of OSCC patients to identify novel biomarkers for OSCC screening. Methods: Microarray screening of circRNA was performed to identify differentially expressed circRNAs in saliva from 3 OSCC patients compared with 3 healthy controls. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the results, and the association between these confirmed salivary circRNAs and clinicopathological features was analyzed using the chi-squared test. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of the circRNAs identified. Preoperative expression and postoperative expression (1 month after the surgery) of hsa_circ_0001874 and hsa_circ_0001971 was also determined. Results: Our results indicated 12 upregulated and 20 downregulated circRNAs in the saliva from the OSCC patients compared with that from the healthy controls. Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). The combination of hsa_circ_0001874 and hsa_circ_0001971 showed an area under the ROC curve of 0.922 (95% confidence interval, 0.883-0.961; P< 0.001). The risk score based on the combination of hsa_circ_0001874 and hsa_circ_0001971 also discriminated patients with OSCC from patients with oral leukoplakia (P< 0.001). Moreover, the expression levels of salivary hsa_circ_0001874 and hsa_circ_0001971 were clearly decreased in the postoperative samples compared with preoperative samples (P< 0.001). Conclusions: This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC.

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“…Among the included publications, a total of 43 articles on 64 studies were analyzed involving 10,123 subjects in Table . Of the 64 studies, five studies focused on colorectal cancer (Ji et al, ; Wang, Li, et al, ; Wang et al, ; Zhang, Yang, et al, ; Zhuo, Lin, Chen, Huang, & Hu, ), 10 on breast cancer (Lu et al, ; Yin et al, ), 22 on gastric cancer (Chen, Li, Zhao, Xiao, & Guo, ; Huang, He, Liang, Huang, & Zhu, ; Li, et al, , ; Li, Shao, et al, ; Li, Song, et al, ; Lu et al, ; Lu, Shao, Ye, Xiao, & Guo, ; Shao, Chen, et al, ; Shao, Li, et al, ; Shao, Yang, et al, ; Sun, Tang, et al, ; Tian, Chen, Li, & Xiao, ; Wei et al, ; Xie et al, ; Zhao, Chen, Li, Xiao, & Zhang, ), four on lung cancer (Li, Wang, Chen, Chen, & Jin, ; Zhu et al, ; Zong et al, ), 16 on hepatocellular carcinoma (Chen, Zhang, Lin, Song, & Wang, ; Fu et al, , ; Li et al, ; Qin et al, ; Shang et al, ; Yao et al, ; Yao et al, ; Zhang, Zhang, Lin, & Wang, ; Zhang, Zhou, et al, ; Zhang, Xu, et al, ) and seven on other cancers (Fan, Cao, Liu, Zhang, & Li, ; Lan et al, ; Li et al, ; Sun, Li, et al, ; Teng et al, ; Wang, Xue, et al, ; Yang et al, ). Moreover, three articles with 13 studies explored the diagnostic value of the combined circRNAs (Chen, Li, Zhao, et al, ; Fan et al, ; Li, Shao, et al, ) in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Multiple studies found that single circRNAs yield good diagnostic performance in tissue or plasma (Shang et al, ; Sun, Tang, et al, ; Wang, Li, et al, ; Zong et al, ). Moreover, several studies provided that single circRNAs in combination with other plasma protein biomarkers such as CEA, CA‐15.3, CA‐125 and AFP possess better diagnostic performance (Huang et al, ; Prefumo, ; Yang et al, ; Yin et al, ; Zhang, Yang, et al, ). Additionally, a single circRNA combined with other circRNAs obtained also had better diagnostic accuracy (Li, Chen, et al, ; Li, Shao, et al, ; Ren & Xin, ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of circular RNAs in human cancers: A systematic review and meta‐analysis

et al. 2019

Molec Gen & Gen Med

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Background Recently, accumulating evidence have revealed that circular RNA (circRNA) was deregulated in multiple types of cancer, suggesting that circRNA might serve as a novel candidate biomarker of cancer diagnosis. However, inconsistent results have become an obstacle in applying circRNAs to clinical practice. The aim of this study is to evaluate diagnostic value of circRNAs among cancers. Methods A literature search was systematically performed among PubMed, Sciencedirect, Cochrane Library, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases up to February 15, 2019. The pooled sensitivity (SEN), specificity (SPE), positive likelihood ratios, negative likelihood ratios, diagnostic odds ratio, and area under the SROC curve (AUC) were applied to evaluate diagnostic performance of circRNAs. Results In total, the study included 64 studies with single circRNA and 13 studies with combined circRNAs. Overall, the study presented that a single circRNA had moderate diagnostic value, with a SEN of 0.75, a SPE of 0.76, and an AUC of 0.82. The plasma circRNAs had higher diagnostic accuracy than tissue (AUC: 0.87, 95% confidence interval [CI]: 0.83–0.89 for plasma/serum subgroup; AUC: 0.79, 95% CI: 0.75–0.82 for tissue subgroup). Furthermore, the combined circRNAs had good diagnostic efficacy for GC, with a SEN of 0.89, a SPE of 0.94, and an AUC of 0.97, respectively. Conclusion This study confirmed that circRNAs may be candidate biomarkers for cancer diagnosis. In particular, diagnosis of combined circRNAs will be a new alternative applied to clinical research and practice for cancer.

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Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection

Cited by 143 publications

References 26 publications

Circular RNA; a new biomarker for breast cancer: A systematic review

Circular RNA; a new biomarker for breast cancer: A systematic review

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Diagnostic performance of circular RNAs in human cancers: A systematic review and meta‐analysis

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