Circulating Chlamydia pneumoniae DNA and advanced coronary artery disease

Wang, Shaoshan S.; Tondella, M. Lucia; Bajpai, Ambar; Mathew, Anil G.; Mehranpour, Payam; Li, Wei; Kacharava, Andro G.; Fields, Barry S.; Austin, Harland; Zafari, A. Maziar

doi:10.1016/j.ijcard.2006.07.013

Cited by 30 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study there was no correlation found between hypercholesterolemia, infection by pneumonia, and clinical signs of destabilization of the atherosclerotic plaque. That finding is similar to other reports 7,23 . Diabetes mellitus was also separately analyzed; the results (Table 4), did not show any relation between the agents analyzed, similarly to the other analyses of rFs.…”

Section: Discussionsupporting

confidence: 94%

“…Diabetes mellitus was also separately analyzed; the results (Table 4), did not show any relation between the agents analyzed, similarly to the other analyses of rFs. That finding is also corroborated by other authors 7,23 . The possibility of pneumoniae acting selectively or preferably among the main brain arteries was also studied, and was not corroborated.…”

Section: Discussionsupporting

confidence: 91%

“…Arterial hypertension (Table 4) did not show any relation between the active infection by pneumoniae and the occurrence of symptoms, that could translate into an instability of the atherosclerotic plaque. Similar results were described in literature 7,23 , that support the idea that arterial hypertension has no influence over a possible atherogenic role related to the infection caused by that agent. Smoking has been frequently mentioned in literature as a related rF to pneumoniae 2 ; though in our casuistic (Table 4) the results did not corroborate that hypothesis, for there was no larger positivity among smokers related to the diagnosis for pneumoniae.…”

Section: Discussionsupporting

confidence: 90%

See 2 more Smart Citations

Chlamydia pneumoniae and stroke: is there a direct relationship?

Gagliardi¹,

Caiaffa-Filho²

2009

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Objective: To investigate the possible relationship between atherothrombotic stroke and Chlamydia pneumoniae. Method: 150 patients with carotid atherothrombosis were enrolled. The casuistic was divided in three groups: ischemic stroke (IS): 65 patients; transient ischemic attack (TIA): 26 patients; and control: 59. The IS or TIA onset was up to 30 days from the beginning of the study. Carotid atheromatoses was diagnosed by Doppler-ultrasonography. Patients with cardioembolic risk or non-atherothrombotic origin were excluded. Comparisons were done between the three groups, and within each group according to the different age subgroups, to the main arteries affected, and to the atherogenic risk factors. Bacteria detection was done using polimerase chain reaction. Results: Only one patient tested positive for C. pneumoniae belonging to the control group. Conclusion: These results do not suggest that C. pneumoniae participated in the onset of IS or TIA or that it has a role in carotid plaque destabilization.Key WOrDS: stroke, chlamydia, atherosclerosis, risk factors, cerebral infarct.Chlamydia pneumoniae e acidente vascular cerebral aterotrombótico: existe relação direta?Resumo -Objetivo: Investigar a possível relação entre Chlamydia pneumoniae e acidente vascular cerebral aterotrombótico (AVC). Método: 150 pacientes com aterotrombose carotídea foram estudados. A casuística foi dividida em 3 grupos: AVC: 65 pacientes; ataque isquêmico transitório (AIT): 26 pacientes e controles: 59. O início do AVC ou AIT era até 30 dias da inclusão no estudo. A ateromatose carotídea foi diagnosticada por ultrassonografia com Doppler. Os pacientes com risco cárdio-embólico ou sem evidência de aterotrombose foram excluídos. Foram estabelecidas comparações entre os 3 grupos e dentro de cada grupo, formado subgrupos de acordo com diferentes idades, território arterial comprometido e fatores de risco. A detecção da bactéria foi feita por reação de polimerização em cadeia. Resultados: Somente um paciente, pertencente ao grupo controle, teve resultado positivo. Conclusão: estes achados não sugerem que a C. pneumoniae participe no desencadeamento do AVC ou AIT ou que tenha papel na desestabilização da placa. PAlAVrAS-ChAVe: acidente cerebral vascular, aterosclerose, fatores de risco, infarto cerebral, chlamydia. Several studies have reported infections as a risk factor for stroke (AVC) 1,2 which could act in the unleashing, the progression or the destabilization of the atherosclerotic plaque 1 . The confirmation of such hypothesis would open an important space, both for an eventual specific therapeutic approach in the acute phase of the stroke and for its prevention. There is an increasing volume of evidences suggesting the association between inflammation, infection, and atherosclerosis 3,4 , although that relation is still not well established 5 . There are authors that defend that the inflammation is the key for the development and the progression of atherothrombosis 3,6 . The most frequent infectious agent implicated to ather...

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Chlamydia pneumoniae and stroke: is there a direct relationship?

Gagliardi¹,

Caiaffa-Filho²

2009

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…The half-marks in the pathogenesis of aortic aneurysms are destruction of elastin and collagen combined with adventitial inflammation, however their etiology are complex and multifactorial [19]. Infections with bacteria such as C. pneumoniae are proposed to trigger the secretion of inflammatory cytokines that leads to atherogenesis with activation of TLRs- [20][21][22]. However, different techniques have yielded different rates of infection in atherosclerotic lesions.…”

Section: Discussionmentioning

confidence: 99%

Involvement of TLR2 and TLR4, Chlamydophila pneumoniae and Mycoplasma pneumoniae in adventitial inflammation of aortic atherosclerotic aneurysm

Assis¹,

Higuchi²,

Reis³

et al. 2014

WJCD

View full text Add to dashboard Cite

Aortic atherosclerotic aneurysm (AAA) is associated with adventitial inflammation where infection is suggested to have a role. Co-infection withChlamydophila pneumoniae (Cp) and Mycoplasma pneumoniae (Mp) was linked with coronary plaque rupture, in association with vessel dilatation and adventitial inflammation. Pathogens are recognized by Toll-like receptors (TLRs) development of the inflammatory process. Objective: Here, we studied whether co-infection by Cp and Mp was involved in the increased inflammation present in AAA and if it could be associated with deficient expression of TLRs. We compared human samples of AAA with non-dilated human aortic atherosclerotic lesions, regarding the amount of Cp and Mp antigens, and expression of TLR2 and TLR4. Methods: Two groups of aorta fragments were analyzed: G1 (n = 13) moderate atherosclerosis and G2 (n = 14) AAA samples, through immunohistochemistry and in situ hybridization methods. Results: Mp and Cp antigens in intima/medial layer were greater in G2 than G1, with no difference in adventitia. TLR2 and TLR4 were higher in G2 than G1 adventitia fat. There was a correlation between Mp versus TLR2 and of TLR4 in intima/medial layer and in adventitia of G1, but there was a lack of correlation in G2. In Cp adventitia, the correlation in G1 was high with TLR2 but not with TLR4, and in G2 the correlation was positive for both TLRs. Conclusion: This study favors the concept that symbiotic co-infection by Cp and Mp participates in the pathogenesis of AAA. It also emphasizes that adventitial fat is the initial site for colonization of these bacteria that probably reach the tissue through vasa vasorum. An exacerbated immune reaction is not efficient to control the infection that reaches and proliferates in high levels at the medial and intimal layer, contributing to the development of vessel dilatation.

show abstract

“…It is believed that C. pneumoniae -infected monocytes circulating in the blood penetrate the arterial wall and eventually cause widespread distribution of the microorganism in atherosclerotic lesions [10][11][12]67] . This possibility is supported by experimental studies [28,68,69] .…”

Section: Discussionmentioning

confidence: 99%

Decreased Expression of Liver X Receptor-α in Macrophages Infected with Chlamydia pneumoniae in Human Atherosclerotic Arteries in situ

Bobryshev¹,

Orekhov²,

Killingsworth³

et al. 2011

J Innate Immun

View full text Add to dashboard Cite

In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atherosclerosis is not known. In this study we examined carotid artery segments, obtained by endarterectomy, in which the presence of C. pneumoniae was confirmed by both polymerase chain reaction and immunohistochemistry. The expression of LXR-α in macrophages infected with C. pneumoniae and macrophages that were not infected was compared using a quantitative immunohistochemical analysis. The analysis revealed a 2.2-fold reduction in the expression of LXR-α in C. pneumoniae-infected cells around the lipid cores in atherosclerotic plaques. In the cytoplasm of laser-capture microdissected cells that were immunopositive for C. pneumoniae, electron microscopy demonstrated the presence of structures with the appearance of elementary, reticulate and aberrant bodies of C. pneumoniae. We conclude that LXR-α expression is reduced in C. pneumoniae-infected macrophages in human atherosclerotic lesions which supports the hypothesis that C. pneumoniae infection might suppress LXR expression in macrophages transforming into foam cells.

show abstract

Circulating Chlamydia pneumoniae DNA and advanced coronary artery disease

Cited by 30 publications

References 45 publications

Chlamydia pneumoniae and stroke: is there a direct relationship?

Chlamydia pneumoniae and stroke: is there a direct relationship?

Involvement of TLR2 and TLR4, <i>Chlamydophila pneumoniae</i> and <i>Mycoplasma pneumoniae</i> in adventitial inflammation of aortic atherosclerotic aneurysm

Decreased Expression of Liver X Receptor-α in Macrophages Infected with <i>Chlamydia pneumoniae</i> in Human Atherosclerotic Arteries in situ

Contact Info

Product

Resources

About

Circulating Chlamydia pneumoniae DNA and advanced coronary artery disease

Cited by 30 publications

References 45 publications

Chlamydia pneumoniae and stroke: is there a direct relationship?

Chlamydia pneumoniae and stroke: is there a direct relationship?

Involvement of TLR2 and TLR4, &lt;i&gt;Chlamydophila pneumoniae&lt;/i&gt; and &lt;i&gt;Mycoplasma pneumoniae&lt;/i&gt; in adventitial inflammation of aortic atherosclerotic aneurysm

Decreased Expression of Liver X Receptor-α in Macrophages Infected with <i>Chlamydia pneumoniae</i> in Human Atherosclerotic Arteries in situ

Contact Info

Product

Resources

About

Involvement of TLR2 and TLR4, <i>Chlamydophila pneumoniae</i> and <i>Mycoplasma pneumoniae</i> in adventitial inflammation of aortic atherosclerotic aneurysm