Circulating CD62E+ Microparticles and Cardiovascular Outcomes

Chu, Kon; Jung, Keun‐Hwa; Kim, Jeong‐Min; Moon, Hye-Jin; Bahn, Jae-Jun; Im, Wooseok; Sunwoo, Jun Sang; Moon, Jangsup; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu

doi:10.1371/journal.pone.0035713

Cited by 68 publications

(55 citation statements)

References 33 publications

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“…The elevated levels of circulating endothelial microparticles are associated with endothelial dysfunction observed in hypertension, coronary artery diseases, ischaemic stroke, diabetes and other cardiovascular events (19,(25)(26)(27). It has been suggested that these microparticles are implicated in the regulation of coagulation, oxidative stress, inflammation, angiogenesis and apoptosis (18,28).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Kam

Razmovski-Naumovski

et al. 2015

J Pharm Pharm Sci

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-PURPOSE:Circulating microparticles have been highlighted as biomarkers of cardiovascular disease state and progression. The aim of this study was to evaluate the effects of curcumin on microparticle release from endothelial cells undergoing TNF-induced cell activation and apoptosis. METHODS: This study evaluated the effects of curcumin on microparticle release, cytotoxicity, apoptosis, cell adhesion molecule expression and monocyte adhesion in EAhy926 human endothelial cells. RESULTS:The results showed that the numbers of microparticles were increased by tumour necrosis factor (TNF) or the combination of TNF and cycloheximide (CHX). Curcumin attenuated microparticle release caused by TNF or TNF plus CHX treatments. The pretreatment by curcumin not only negated the accelerated cell death and apoptosis caused by TNF and CHX, but also diminished TNF-induced cell activation, as assessed by reduced surface expression of intercellular adhesion molecule 1, and adhesion of monocytes to endothelial monolayers. CONCLUSION: Curcumin reduced microparticle release from endothelial cells undergoing cell activation and apoptosis, which supports its protective role in TNF-associated endothelial dysfunction, and highlights its potential use as a nutraceutical agent for vascular inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Kam

Razmovski-Naumovski

et al. 2015

J Pharm Pharm Sci

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“…Circulating levels of EMPs increase in plasma early in atherosclerotic processes, correlate with the degree of endothelial dysfunction (100), and have been established as prognostic biomarkers that predict adverse cardiovascular outcome (5,6,54,90). Cardiovascular risk factors may trigger endothelial MP release (3, 79, 92).…”

Section: Endothelial Injury Circulating Endothelial Mps and Cellsmentioning

confidence: 99%

Central Role of eNOS in the Maintenance of Endothelial Homeostasis

Heiß

Rodriguez-Mateos

Kelm

2015

Antioxidants & Redox Signaling

158

118

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Significance: Disruption of endothelial function is considered a key event in the development and progression of atherosclerosis. Endothelial nitric oxide synthase (eNOS) is a central regulator of cellular function that is important to maintain endothelial homeostasis. Recent Advances: Endothelial homeostasis encompasses acute responses such as adaption of flow to tissue's demand and more sustained responses to injury such as reendothelialization and sprouting of endothelial cells (ECs) and attraction of circulating angiogenic cells (CAC), both of which support repair of damaged endothelium. The balance and the intensity of endothelial damage and repair might be reflected by changes in circulating endothelial microparticles (EMP) and CAC. Flow-mediated vasodilation (FMD) is a generally accepted clinical read-out of NO-dependent vasodilation, whereas EMP are upcoming prognostically validated markers of endothelial injury and CAC are reflective of the regenerative capacity with both expressing a functional eNOS. These markers can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity with NO representing a central signaling molecule. Critical Issues: Improvements of reproducibility and observer independence of FMD measurements and definitions of relevant EMP and CAC subpopulations warrant further research. Future Directions: Endothelial homeostasis may be a clinical therapeutic target for cardiovascular health maintenance. Antioxid. Redox Signal. 22, 1230Signal. 22, -1242

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“…EMV are 3 emerging as a novel marker of vascular risk in cross-sectional but also in prospective 4 studies (Lee et al, 2012;Nozaki et al, 2009) where they can add to risk prediction. This 5 reduction in CD31 + CD41 -EMV was accompanied by a reduction in soluble endothelial 6 markers and acute phase inflammatory proteins.…”

Section: Cd31mentioning

confidence: 99%

Influence of a low-carbohydrate diet on endothelial microvesicles in overweight women

Wekesa

Doyle

Fitzmaurice

et al. 2016

Appl. Physiol. Nutr. Metab.

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Low-carbohydrate diets (LCD) are increasing in popularity, but their effect on vascular health has been questioned. Endothelial microvesicles (EMV) are membrane-derived vesicles with the potential to act as a sensitive prognostic biomarker of vascular health and endothelial function. The aim of this study was to examine the influence of a LCD on EMV and other endothelial biomarkers of protein origin. Twenty-four overweight women (age, 48.4 ± 0.6 years; height, 1.60 ± 0.07 m; body mass, 76.5 ± 9.1 kg; body mass index, 28.1 ± 2.7 kg·m−2; waist circumference, 84.1 ± 7.4 cm; mean ± standard deviation) were randomised to either 24 weeks on their normal diet (ND) or a LCD, after which they crossed over to 24 weeks on the alternative diet. Participants were assisted in reducing carbohydrate intake, but not below 40 g·day−1. Body composition and endothelial biomarkers were assessed at the crossover point and at the end of the study. Daily carbohydrate intake (87 ± 7 versus 179 ± 11 g) and the percentage of energy derived from carbohydrate (29% versus 44%) were lower (p < 0.05) on the LCD compared to the ND, but absolute fat and saturated fat intake were unchanged. Body mass and waist circumference were 3.7 ± 0.8 kg and 3.5 ± 1.0 cm lower (p < 0.05), respectively, after the LCD compared with the ND phases. CD31+CD41−EMV, soluble (s) thrombomodulin, sE-selectin, sP-selectin, serum amyloid A and C-reactive protein were lower (p < 0.05) after the LCD compared to the ND, but serum lipids and apolipoproteins were not different. EMV along with a range of endothelial and inflammatory biomarkers are reduced by a LCD that involves modest weight loss.

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Circulating CD62E+ Microparticles and Cardiovascular Outcomes

Cited by 68 publications

References 33 publications

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Central Role of eNOS in the Maintenance of Endothelial Homeostasis

Influence of a low-carbohydrate diet on endothelial microvesicles in overweight women

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