Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Kong, Fanhua; Ma, Liang; Ge, Li; Chen, Yixin; Zhou, Jian

doi:10.1371/journal.pone.0169941

Cited by 25 publications

(15 citation statements)

References 32 publications

(42 reference statements)

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“…In adults, ANGPTL8/betatrophin was introduced as an emerging potential player in dyslipidemia with strong association with HDL-Chol and a potential therapeutic tool for the treatment of dyslipidemia [43] . Significantly increased ANGPTL8/betatrophin levels were reported in T2DM with CVDs, T1DM, gestational DM, obesity and MetS [15,[44][45][46][47][48][49] . In an experimental study, ANGPTL8/betatrophin overexpression led to dramatically increased serum TRG levels [50] .…”

Section: Fig 3 Partial Correlation Between Pentraxin-3 and Angiopoiementioning

confidence: 95%

Pentraxin-3, Angiopoietin-Like Protein-3, Angiopoietin-Like Protein-4 and Angiopoietin-Like Protein-8 Levels in Morbid Obese Children

2017

Med One

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A low-grade inflammatory state accompanies obesity and metabolic syndrome (MetS), which are risk factors for cardiovascular diseases (CVD) in children's future lives. The aim of this study is to investigate possible associations of pentraxin 3 (PTX3), a promising new marker for CVDs, with angiopoietin-like proteins (ANGPTL) in morbid obese (MO) children and their potential uses in the prediagnosis of MetS. Thirty normal weight (NW) and 50 MO prepubertal children without MetS symptoms, a total of 80, participated in the study. Using percentile tables for age and gender recommended by WHO, children whose percentiles were between 15-85 and above 99 were included in NW and MO groups, respectively. Anthropometric measurements, BMI and HOMA-IR values were recorded. Serum PTX3, ANGPTL3, ANGPTL4, ANGPTL8/betatrophin levels were determined by enzymelinked immunosorbent assay (ELISA). Statistical analyses were performed by SPSS. p < 0.05 was the degree of statistical significance. There were no differences between PTX3, ANGPTL3 and ANGPTL4 levels of groups. ANGPTL8/betatrophin levels were significantly higher in MO children (p ≤ 0.001). A significant correlation was observed between PTX3 and ANGPTL4 (r = 0.297, p ≤ 0.05) in the same group. When adjusted for MetS parameters including HDL-Chol, correlations http://mo.qingres.com

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Section: Fig 3 Partial Correlation Between Pentraxin-3 and Angiopoiementioning

confidence: 95%

Pentraxin-3, Angiopoietin-Like Protein-3, Angiopoietin-Like Protein-4 and Angiopoietin-Like Protein-8 Levels in Morbid Obese Children

2017

Med One

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“…Adipose tissue, recognized as an important endocrine organ, has attracted much attention due to its effect on few metabolic processes such as glucose homeostasis, lipid metabolism, inflammation, and blood pressure. Betatrophin, also known as “ANGPTL8,” “RIFL,” “C19ORF80,” “TD26,” and “lipasin,” is a novel adipokine secreted from the adipose tissue and the liver [3]. Recent studies have indicated that betatrophin is linked to glucolipid disorders [4].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Qin

Wang

et al. 2019

Disease Markers

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In this study, we evaluated the relationship between circulating betatrophin levels and obesity. Obesity is a common public health problem that is increasing globally. Betatrophin, a newly identified protein, is predominantly expressed in white and brown fat tissues and in the liver. Growing evidence suggests that betatrophin plays a pivotal role in metabolism, including the synthesis and degradation of lipids in cells, and adipocyte differentiation. Previous studies have assessed the association between circulating betatrophin levels and obesity; however, this relationship remains unclear. Therefore, our study is aimed at examining the impact of betatrophin on obesity using a meta-analysis of the current evidence. We performed a meta-analysis to quantify the relationship between betatrophin levels and obesity. A literature search was conducted through the EMBASE, Web of Science, and MEDLINE databases. Retrieved studies were screened, without any language restrictions to identify relevant literature published up to December 2018. Observational studies, in which the association between circulating concentrations of betatrophin and obesity was evaluated, were considered suitable for the systematic review. Of the 65 manuscripts retrieved, 9 datasets from 6 studies, involving 681 participants, detected an association between circulating betatrophin and obesity. Circulating betatrophin levels of obese subjects were higher than those of nonobese subjects (random − effects weighted mean difference (WMD) = 0.250 μg/mL, 95% CI: 0.048–0.451, I2 = 94.8%, p = 0.015), yet with significant between-study heterogeneity. This heterogeneity appeared to be modified by glycemic status but not by age, the ELISA kits used, sample source, or body mass index. The high circulating betatrophin concentration may directly increase the risk of obesity in adults. Betatrophin may serve as a therapeutic target for obesity in adults.

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“…[ 18 ] However, there is still ambiguity as to the levels of betatrophin between GDM and normal pregnant women. A meta-analysis [ 19 ] and a study by Ebert et al [ 20 ] demonstrated that plasma betatrophin levels are higher in GDM patients compared with normal healthy pregnant women. In contrast, Huang et al [ 21 ] reported that betatrophin levels are lower in pregnant GDM women compared with normal healthy pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Association of betatrophin amounts with 25-(OH)D levels in patients with gestational diabetes mellitus

Fuyan¹,

Yang²,

Wang³

et al. 2021

Medicine

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To determine the association of betatrophin amounts with 25-(OH)D levels in gestational diabetes mellitus (GDM) patients, and to provide new targets for the prevention and treatment of GDM. This study included 40 GDM patients (GDM group) and 37 healthy pregnant women (control group). Betatrophin, 25-(OH)D, fasting blood glucose (FBG), HbA1c, hsCRP, and FINS levels in peripheral blood, as well as betatrophin and 25-(OH)D amounts in cord blood, were measured. Then, associations of betatrophin levels with 25-(OH)D amounts and other indexes were determined. Maternal ( P = .011) and cord ( P = .022) blood betatrophin levels were significantly lower in the GDM group compared with control group. Cord blood betatrophin levels were higher compared with maternal blood amounts in both the GDM and control groups (both P = .000). Serum betatrophin levels were positively associated with 25-(OH)D levels ( r = 0.677, P = .000), but negatively associated with hsCRP ( r = −0.335, P = .037) and HOMA-IR ( r = −0.346, P = .031) levels in the GDM group. Fetal weight was higher in the GDM group compared with control group ( P = .023), and negatively associated with cord blood betatrophin amounts in the GDM group ( r = −0.342, P = .031). However, cord blood betatrophin levels were not significantly associated with body length, Apgar score, and cord blood 25-(OH)D levels in the GDM group (all P > .05). Serum betatrophin and 25-(OH) D levels were positively associated in women with GDM, and both significantly lower compared with control values. Fetal weight was higher in the GDM group and associated with cord blood betatrophin. These findings provide insights into developing new predictive biomarkers or therapeutic targets for GDM.

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Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 25 publications

References 32 publications

Pentraxin-3, Angiopoietin-Like Protein-3, Angiopoietin-Like Protein-4 and Angiopoietin-Like Protein-8 Levels in Morbid Obese Children

Pentraxin-3, Angiopoietin-Like Protein-3, Angiopoietin-Like Protein-4 and Angiopoietin-Like Protein-8 Levels in Morbid Obese Children

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Association of betatrophin amounts with 25-(OH)D levels in patients with gestational diabetes mellitus

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