Circulating B Cells, Plasma Cells, and Treg Associate with ANCA Levels in ANCA-associated Vasculitis

Abstract

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Coexistence of double seropositivity for MPO antibody and anti-GBM antibody in ANCA-associated vasculitis concurrent with multiple myeloma: A case report

“…Patients with AAV exhibit higher proportions of B lymphocytes and plasma cells than healthy controls. [ 16 , 17 ] Other studies have shown that rheumatologic diseases like AAV affect the risk of MM or other lymphoproliferative disorders progressed from monoclonal gammopathy of undetermined significance (MGUS). [ 18 ] In another cohort of 16 individual case studies, all patients were positive for anti-PR3 and anti-MPO antibodies and were diagnosed with MM.…”

Weighted Gene Correlation Network Analysis Applied to Identify the Immune Cell-related Hub Genes in ANCA Nephritis

“…Experimental results showed that there were antigen-speci c effector CD4 + T cells in peripheral blood during the acute infection stage of AAV, and the depletion of CD4 + T cells alleviated the progression of the disease [10]. As report, the B cells, plasma cells and Treg cells in circulating blood of AAV patients were higher than those in healthy controls [11]. Monocytes have also been shown to accumulate in crescents of necrotizing glomerulonephritis [12].…”