Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure

Multiplicity of molecular and cellular targets in human ovarian autoimmunity: an update

“…Of these, two demonstrated antibodies to the mouse zona pellucida as well as strong immunoreactivity to granulosa cells, while the remaining eight exhibited anti-ZP antibodies with negligible staining in granulosa cells. These results were also confirmed by porcine ZP coated in ELISA [23]. Results from these studies thus suggest that ZP could be an important ovarian antigen in autoimmune POF.…”

Thyroid disorders and fertility

“…17 According to the hypothesis of a recent study, zona pellucida becomes a target for ATA since it has antigen groups similar to thyroid and thus fertility was negatively affected. 44 Similarly, according to the hypothesis in the study of Monteleone et al ATA within the follicle fluid damages oocyte maturation and thus success rate following ART decreases 45 . Even though above mentioned studies have demonstrated positive relation between AITD and low ART success rate, in 1999 Kutteh el al have shown that there is no significant difference between pregnancy positive and pregnancy negative patients after ART.…”

Ovarian Biomarkers in Infertility

“…The antibody-mediated autoreactivity directed towards the granulosa cells has been reported in the sera of POF patients (Damewood et al, 1986, Kelkar et al, 2005. AOA in POF patients showed immunoreactivity against the granulosa cells from both the pre-antral and the antral follicles (Damewood et al, 1986).…”

“…Zona pellucida proteins play critical role in oocyte fertilization. Anti-ZP autoantibodies have been linked with human female infertility (Ivanova et al1994, Mardesic et al, 2000, Kelkar et al, 2005, Koyama, 2010. Intra cytoplasmic sperm injection (ICSI) is recommended option for IVF therapy of women with anti-ZP autoantibodies (Mardesic et al, 2000).…”