Circulating Antidiuretic Hormone During Labour and in the Newborn

Leung, Alexander K. C.; McArthur, Robert G.; McMillan, Douglas; Ko, David; Deacon, J. S.; Parboosingh, John; Lederis, K.

doi:10.1111/j.1651-2227.1980.tb07122.x

Cited by 33 publications

(18 citation statements)

References 9 publications

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“…This point of view is supported by another study [9], in which infants delivered by forceps had lower AVP levels than those delivered without forceps in spite of a considerably longer second stage of labor.…”

Section: Discussionsupporting

confidence: 75%

“…As in the present study, how ever, others have found high concentrations of AVP in umbilical arterial cord blood at the time of birth [3,5,9] and animal experiments have shown that the fetus is autonomic with respect to AVP secretion and the placenta impermeable to AVP [1,10,11], Hadeed et al [12] have suggested that intracranial pres sure elevation resulting from labor and birth stimulates AVP secretion in the fetus. The longer and more severe the compression, judged by the degree of asphyxia, the higher the AVP secretion.…”

Section: Discussionmentioning

confidence: 54%

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Arginine Vasopressin in Amniotic Fluid, Arterial and Venous Cord Plasma and Maternal Venous Plasma

Johannesen¹,

Pedersen²,

Rasmussen³

1985

Gynecol Obstet Invest

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High concentrations of arginine vasopressin (AVP) in arterial umbilical cord blood at the time of delivery have been attributed to either a generalized increase in the activity of the fetal endocrine system at the onset of labor or to fetal asphyxia. We measured AVP in amniotic fluid, arterial and venous cord blood and in maternal venous blood from 13 patients at 38–40 weeks of gestation at the time of elective cesarean section with a nonasphyxic fetus (group I), in amniotic fluid from 19 patients at 15–17 weeks of gestation (group II) and in venous blood from 13 nonpregnant control subjects (group III). Our results showed a high concentration of AVP in the amniotic fluid both in the middle and at the end of normal pregnancy and at the same level as in arterial cord blood, whereas AVP in the venous cord blood was significantly lower and at the same level as in the maternal venous blood and in the control group. It is concluded that the fetus produces AVP and this is at least not solely caused by fetal asphyxia or related to parturition.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 54%

Arginine Vasopressin in Amniotic Fluid, Arterial and Venous Cord Plasma and Maternal Venous Plasma

Johannesen¹,

Pedersen²,

Rasmussen³

1985

Gynecol Obstet Invest

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“…Elevated levels of AVP have been measured at the time of delivery in human newborns and were especially high in those judged to have a difficult labor with fetal distress. 34 Of particular interest is the remarkable correlation between AVP levels and cervical dilation before cesarean section. 35 With greater cervical dilation, the head has progressed further into the birth canal and pressure on the skull is presumably greater.…”

Section: Hormonal Responsementioning

confidence: 99%

Cerebral and peripheral circulatory responses to intracranial hypertension in fetal sheep.

Harris

Koehler

Gleason

et al. 1989

Circulation Research

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“…Moreover, [VP] measurements in umbilical cord blood of vaginally delivered human infants are considerably greater than they are in fetal sheep (22-26, 34, 35). Values are greater in umbilical arterial than in umbilical venous blood, with plasma concentrations sometimes in excess of 600 pU/mL (25,34,35).…”

Section: Discussionmentioning

confidence: 98%

Vasopressin Effects on Lung Liquid Volume in Fetal Sheep

et al. 1995

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The normal switch from placental to pulmonary gas exchange at birth requires rapid removal of liquid from the lungs. Previous reports contend that vasopressin may be important in regulating this process, but this notion derives from studies in which fetal sheep received very large doses of vasopressin that yielded plasma concentrations at least 10 times greater than those that have been measured during normal labor. To study the physiologic effects of vasopressin on lung liquid volume in fetal sheep, we made three sets of experiments. First, we measured plasma vasopressin concentrations [VP] in 15 late-gestation fetal sheep, five of which were at various stages of spontaneous labor. [VP] in these fetuses ranged from <1 (prelabor) to 31 (during labor) pU/mL; postmortem extravascular lung water (EVLW) ranged from 4.5 to 14.5 gig dry lung tissue. In a second series of studies, we measured EVLW in five sets of near-term (138 + 1 d, term = 147 d) twin fetal sheep that received an 8-h i.v. infusion of either isotonic saline (control twin) or AVP (AVP-treated twin) at a rate of -1 (mU/kg)/min. This dose was chosen to mimic [VP] measured in fetuses that had been studied during labor.[VP] did not change in the control twins, whereas [VP] increased from 1.8 + 1.0 to 27.7 + 3.5 pU/mL in treated twins. There was a small, statistically significant difference in EVLW between twins that received AVP and untreated twins (11.9 + 1.8 versus 14.6 + 2.8 gig dry lung). In a third series of studies, we measured net production of lung liquid (Jv) by an indicator dilution technique in 16 fetal sheep that received an i.v. infusion of isotonic saline for 2 h followed by AVP for up to 8 h.[VP] averaged 23.4 t 6.5 pU/mL during AVP infusion. For six fetuses that were studied at I32 d (135 + 2 d) gestation, Jv decreased from 11.3 + 4.7 mL/h during the control period to 8.6 During fetal life, the lungs are filled with liquid that forms as a result of epithelial C1-secretion into the lumen of the developing respiratory tract (1). Rapid removal of this liquid from potential airspaces is an essential step in establishing an effective switch from placental to pulmonary gas exchange at

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Circulating Antidiuretic Hormone During Labour and in the Newborn

Cited by 33 publications

References 9 publications

Arginine Vasopressin in Amniotic Fluid, Arterial and Venous Cord Plasma and Maternal Venous Plasma

Arginine Vasopressin in Amniotic Fluid, Arterial and Venous Cord Plasma and Maternal Venous Plasma

Cerebral and peripheral circulatory responses to intracranial hypertension in fetal sheep.

Vasopressin Effects on Lung Liquid Volume in Fetal Sheep

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