Circulating antibodies to human spermatozoa in patients with ulcerative colitis

Dimitrova, D.; Kalaydjiev, S.; Mendizova, A; Piryova, Evgeniya; Nakov, L

doi:10.1016/j.fertnstert.2005.05.041

Cited by 32 publications

(12 citation statements)

References 15 publications

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“…In this context, it is interesting to refer to the published associations between the HLA-DQB1∗03 allele, and the presence of the sperm-immobilizing antibodies in cervical secretions [108]. Higher production of antisperm antibodies has been detected in patients with increased intestinal permeability in bowel inflammatory disease, as a result of immunization against intestinal microbes, which seems to share common antigenic epitopes with spermatozoa [109]. Consequently, the elevated levels of anti-FSH IgA antibodies in IVF patients could be explained by an upregulation of the normal mucosal immune response.…”

Section: Anti-fsh Antibodies Being Primarily Natural Antibodiesmentioning

confidence: 99%

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Haller-Kikkatalo

Salumets

Uibo

2012

Clinical and Developmental Immunology

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Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against β-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.

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Section: Anti-fsh Antibodies Being Primarily Natural Antibodiesmentioning

confidence: 99%

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Haller-Kikkatalo

Salumets

Uibo

2012

Clinical and Developmental Immunology

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“…The following are the various case studies that have attempted to prove an association between antisperm antibodies and bacteria viz. Helicobacter pylori,Ureaplasma urealyticum, E. coli and Shigella and Salmonella [6][7][8][9]. However, the present study provides a direct experimental evidence of the same.…”

Section: Introductionmentioning

confidence: 52%

Shared Antigenic Determinants Between Spermatozoa and Bacteria: An Experimental Study

2019

JGRM

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Sperm immobilization factor (SIF), the secretory protein of Staphylococcus aureus, is known to cause complete immobilization, death and morphological alterations in mouse spermatozoa in vitro. However, the present study aims to explore a newer dimension of SIF i.e., to bind to motile and non-motile bacteria and its ability to induce immobilization of motile bacteria in vitro. The results showed that 800µg of SIF caused complete immobilization of motile bacteria, however, death and morphological alterations could not be observed even with 1000µg of SIF. Furthermore, this SIF-mediated bacterial immobilization was reversed when each of the SIF-binding receptor from mouse spermatozoa and bacteria (Escherichia coli and Streptococcus pyogenes) was incubated with bacteria, thereby, providing an experimental evidence of similarity between the antigenic determinants present on spermatozoa and bacteria against a common ligand, SIF.

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“…IgA alloantibodies to FSH are seen in some normal fertile women and can be produced during tolerance to partner antigens (sperm proteins and shared maternal antigens) through semen [59,60]. Patients with increased intestinal permeability in bowel inflammatory disease show higher production of ASA through molecular mimicry or epitope sharing between intestinal microbes and spermatozoa [61]. An upregulated normal mucosal immune response could lead to the elevated levels of anti-FSH IgA antibodies in IVF patients.…”

Section: Autoantibodies and Cytokinesmentioning

confidence: 99%

Autoantibodies: Key Mediators of Autoimmune Infertility

Kadam¹,

Mande²,

Choudhury³

2019

Autoantibodies and Cytokines

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Autoimmune diseases have gender bias with predominance in females, autoimmune infertility (AI) being no exception. This chapter will focus on AI in females with brief reference to the same in males. Autoimmune diseases have established protocols for detection and management of ensuing infertility, however similar protocols for unexplained infertility [tubal blockage, endometriosis, premature ovarian insufficiency (POI), undiagnosed underlying autoimmune disease (Sjögren's syndrome, IBS, celiac disease) and tubal blockage] are not established. Endometriosis and POI, in particular, have autoimmune etiology yet lack specific and sensitive biomarkers for accurate diagnosis. If autoantibodies are indeed diagnosed, then treatment regimen focuses on AI which has known adverse effects. The detection of natural antibodies as autoantibodies presents a viable alternative to organ specific biomarker panel for better management of AI.

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Circulating antibodies to human spermatozoa in patients with ulcerative colitis

Cited by 32 publications

References 15 publications

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Shared Antigenic Determinants Between Spermatozoa and Bacteria: An Experimental Study

Autoantibodies: Key Mediators of Autoimmune Infertility

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