Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis

Boullerne, Anne I.; Petry, Klaus G.; Geffard, M.

doi:10.1016/0165-5728(96)00010-0

Cited by 39 publications

(29 citation statements)

References 29 publications

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“…As previously discussed, elevated IgM class natural antibodies toward immunogenic oxidatively modified epitopes and nitrosylated proteins are commonly reported in people with multiple sclerosis, major depressive disorder, and CFS [36,37,40,190]. Natural antibodies are so named because they may exist at low levels in a host independently of antigenic stimulation [191].…”

Section: Nitrosylation and Autoimmunitymentioning

confidence: 93%

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Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

Morris¹,

Berk

Klein

et al. 2016

Mol Neurobiol

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Nitric oxide plays an indispensable role in modulating cellular signaling and redox pathways. This role is mainly effected by the readily reversible nitrosylation of selective protein cysteine thiols. The reversibility and sophistication of this signaling system is enabled and regulated by a number of enzymes which form part of the thioredoxin, glutathione, and pyridoxine antioxidant systems. Increases in nitric oxide levels initially lead to a defensive increase in the number of nitrosylated proteins in an effort to preserve their function. However, in an environment of chronic oxidative and nitrosative stress (O&NS), nitrosylation of crucial cysteine groups within key enzymes of the thioredoxin, glutathione, and pyridoxine systems leads to their inactivation thereby disabling denitrosylation and transnitrosylation and subsequently a state described as "hypernitrosylation." This state leads to the development of pathology in multiple domains such as the inhibition of enzymes of the electron transport chain, decreased mitochondrial function, and altered conformation of proteins and amino acids leading to loss of immune tolerance and development of autoimmunity. Hypernitrosylation also leads to altered function or inactivation of proteins involved in the regulation of apoptosis, autophagy, proteomic degradation, transcription factor activity, immune-inflammatory pathways, energy production, and neural function and survival. Hypernitrosylation, as a consequence of chronically elevated O&NS and activated immune-inflammatory pathways, can explain many characteristic abnormalities observed in neuroprogressive disease including major depression and chronic fatigue syndrome/myalgic encephalomyelitis. In those disorders, increased bacterial translocation may drive hypernitrosylation and autoimmune responses against nitrosylated proteins.

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Section: Nitrosylation and Autoimmunitymentioning

confidence: 93%

“…Moreover, these nitrosylated amino acid adducts may become immunogenic as evidenced by elevated IgM levels toward nitrosocysteine, nitroso-tryptophan, nitroso-tyrosine, etc. in the serum or cerebrospinal fluid of people with multiple sclerosis, depression, or chronic fatigue syndrome (CFS) [36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

Morris¹,

Berk

Klein

et al. 2016

Mol Neurobiol

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show abstract

“…How can we understand the activation of the immune system by the ''PAH-NAC-like'' structure? It is well known that the immune system recognizes not only modified [20][21][22][23] and hidden self-antigens [24][25][26][27][28][29], but also self-compounds whose concentrations increase under pathological conditions. For example, previous works in cancer research from our laboratory have described the increase of anti-phosphatidyl inositol (PtdIns) Abs in the sera of cancer patients [30].…”

Section: Discussionmentioning

confidence: 99%

Circulating antibodies directed against “polycyclic aromatic hydrocarbon-like” structures in the sera of cancer patients

Pouns

Mangas

Coveñas

et al. 2009

Cancer Epidemiology

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“…Sur les bases d'études précédentes [19], nous avons recherché les anticorps dirigés contre plusieurs types de motifs antigéniques constituant un ensemble pertinent pour l'analyse biologique de la SEP. Nous effectuons leur quantification à l'aide de tests immunoenzymatiques (tests Elisa) bien éprouvés [2,7,8,12,[15][16][17]22,26,29].…”

Section: Tests D'identification Des Immunoglobulines Circulantes Diriunclassified

“…• les acides gras conjugués et épitopes d'ancrage : acide palmitique (PalM), acide myristique (MyrM), acide oléique (OleM) et farnésylcystéine (FarM) [2,12] ; • l'acide azélaïque (AzeM) et le résidu malondialdéhyde (MDAM) liés à des protéines[2,8,22] ; • le phosphatidyl inositol (PiM)[10].…”

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Suivi immunobiologique de malades atteints de sclérose en plaques

Bodet

Glaize²,

Dabadie³

et al. 2004

Immuno-analyse & Biologie Spécialisée

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Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis

Cited by 39 publications

References 29 publications

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

Circulating antibodies directed against “polycyclic aromatic hydrocarbon-like” structures in the sera of cancer patients

Suivi immunobiologique de malades atteints de sclérose en plaques

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