Circulating angiotensin II and dietary salt: Converging signals for neurogenic hypertension

Osborn, John W.; Fink, Gregory D.; Sved, Alan F.; Toney, Glenn M.; Raizada, Mohan K.

doi:10.1007/s11906-007-0041-3

Cited by 153 publications

(184 citation statements)

References 54 publications

(59 reference statements)

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“…In contrast, in hypertensive states, the D 3 and D 1 receptor interaction is impaired. 16 These reports, however do not preclude that there may be also interaction between D 3 and D 5 receptors. Indeed, the reported interactions between D 2 -like and D 1 -like receptors in vivo did not distinguish the effects exerted specifically by the D 1 or D 5 receptor, because of the lack of selective D 1 and D 5 receptor agonists or antagonists.…”

Section: Introductionmentioning

confidence: 92%

“…16 These reports, however do not preclude that there may be also interaction between D 3 and D 5 receptors. Indeed, the reported interactions between D 2 -like and D 1 -like receptors in vivo did not distinguish the effects exerted specifically by the D 1 or D 5 receptor, because of the lack of selective D 1 and D 5 receptor agonists or antagonists. Because both D 1 and D 5 receptors belong to the D 1 -like receptor family, 8,13 we presume that there is also an interaction between D 3 and D 5 receptors in RPT cells.…”

Section: Introductionmentioning

confidence: 92%

“…1,2 Essential hypertension is heterogeneous and its expression is influenced by genetic and environmental factors. [2][3][4][5] The long-term regulation of blood pressure rests on renal and non-renal mechanisms, and abnormalities in the renal regulation of ion transport, intrinsic and extrinsic to the kidney, have been proposed to cause essential hypertension. [4][5][6] Several studies have reported that an impaired renal dopaminergic system may contribute to the pathogenesis of hypertension.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] The long-term regulation of blood pressure rests on renal and non-renal mechanisms, and abnormalities in the renal regulation of ion transport, intrinsic and extrinsic to the kidney, have been proposed to cause essential hypertension. [4][5][6] Several studies have reported that an impaired renal dopaminergic system may contribute to the pathogenesis of hypertension. 7,8 Dopamine receptors expressed in mammals belong to the a group of the rhodopsin family of G protein-coupled receptors.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, the reported interactions between D 2 -like and D 1 -like receptors in vivo did not distinguish the effects exerted specifically by the D 1 or D 5 receptor, because of the lack of selective D 1 and D 5 receptor agonists or antagonists. Because both D 1 and D 5 receptors belong to the D 1 -like receptor family, 8,13 we presume that there is also an interaction between D 3 and D 5 receptors in RPT cells. In order to test the above hypotheses, we studied D 3 and D 5 receptor interaction in immortalized RPT cells from Wistar-Kyoto (WKY) rats and in D 5 receptor-transfected HEK293 cells.…”

Section: Introductionmentioning

confidence: 99%

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D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells

Ren

Chen

et al. 2012

Hypertens Res

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells

Ren

Chen

et al. 2012

Hypertens Res

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Renal Nerves and Long‐Term Control of Arterial Pressure

Osborn

Foss

2017

Comprehensive Physiology

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The objective of this review is to provide an in-depth evaluation of how renal nerves regulate renal and cardiovascular function with a focus on long-term control of arterial pressure. We begin by reviewing the anatomy of renal nerves and then briefly discuss how the activity of renal nerves affects renal function. Current methods for measurement and quantification of efferent renal-nerve activity (ERNA) in animals and humans are discussed. Acute regulation of ERNA by classical neural reflexes as well and hormonal inputs to the brain is reviewed. The role of renal nerves in long-term control of arterial pressure in normotensive and hypertensive animals (and humans) is then reviewed with a focus on studies utilizing continuous long-term monitoring of arterial pressure. This includes a review of the effect of renal-nerve ablation on long-term control of arterial pressure in experimental animals as well as humans with drug-resistant hypertension. The extent to which changes in arterial pressure are due to ablation of renal afferent or efferent nerves are reviewed. We conclude by discussing the importance of renal nerves, relative to sympathetic activity to other vascular beds, in long-term control of arterial pressure and hypertension and propose directions for future research in this field. © 2017 American Physiological Society. Compr Physiol 7:263-320, 2017.

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