Circulating androgens in male patients suffering from systemic scleroderma

Jemec, Gregor B. E.; Sindrup, J. H.

doi:10.1007/bf00376615

Cited by 6 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is unclear whether free or total serum testosterone was measured in this study. However, a slightly larger study demonstrated significantly higher total serum testosterone and E2 levels in 10 male dcSSc patients compared to age-matched controls [29]. Thus, increased testosterone levels in dcSSc males, as in healthy males, likely drive the elevated serum E2 levels and may explain the difference we observed between dcSSc male and female patients.…”

Section: Discussionmentioning

confidence: 71%

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

et al. 2019

View full text Add to dashboard Cite

Background Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in disease incidence, estradiol (E2), an estrogen form with pro-fibrotic effects, may play a role in SSc. We reported that post-menopausal women with diffuse cutaneous (dc)SSc have higher serum E2 levels compared to similar aged, healthy controls. Since males with SSc tend to have more severe disease, we examined serum E2 in dcSSc males in relation to disease characteristics and survival. Methods We measured serum E2 in 83 dcSSc men > 50 years old from the University of Pittsburgh Scleroderma Center and similar aged healthy controls. Using statistical modeling, we examined the associations between serum E2, internal organ involvement, autoantibody profiles, and survival. Results Male dcSSc patients had significantly higher serum E2 levels compared to healthy males and similar aged dcSSc post-menopausal women. Male dcSSc patients with high serum E2 had significantly more heart involvement, a trend for higher skin thickness progression rate, and worse survival. Using Cox regression modeling, increased serum E2 levels in anti-Scl-70 antibody-positive dcSSc males were associated with an increased risk of death. Conclusions dcSSc males > 50 years old have higher levels of serum E2 compared to healthy controls and dcSSc post-menopausal women. Elevated serum E2 levels in dcSSc males are associated with heart involvement, trend to progression of dermal fibrosis, and, if anti-Scl-70 antibody positive, worse survival. Our study expands on previous work implicating E2 in dermal fibrosis in SSc and associates E2 levels with internal organ involvement and survival. These data suggest a role for estrogen imbalance in dcSSc.

show abstract

Section: Discussionmentioning

confidence: 71%

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In male SSc patients, we observed significantly lower levels of both total testosterone and bioactive testosterone, as compared to age‐matched controls. Two previous studies did not detect any alteration in sex hormone levels in male SSc patients, but those studies were limited by their sample size, while another study showed that the levels of testosterone and SHBG were higher in male SSc patients compared to controls. This may be attributable to differences in sample size and inclusion criteria, since one of the studies included patients with rheumatoid arthritis among the controls, and excluded SSc patients based on the presence of additional comorbidities, including 1 patient with Klinefelter's syndrome.…”

Section: Discussionmentioning

confidence: 87%

Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis

Arnaud

Nordin

Lundholm

et al. 2017

Arthritis & Rheumatology

View full text Add to dashboard Cite

The results of this study highlight the negative impact of corticosteroids on gonadal function in men with SLE. Furthermore, use of CYC during the year prior to study inclusion impaired bioactive testosterone levels in male patients with either SLE or SSc. Physicians should be more aware of the possibility of hypogonadism in male patients with autoimmune diseases. The need for hormonal supplementation remains to be formally evaluated in these patients.

show abstract

“…Existem apenas alguns relatos de casos de esclerodermia em pacientes com síndrome de Klinefelter 21,22 , e foi descrito que homens com esclerodermia sistêmica apresentam ní-veis mais elevados de estradiol circulante 23 . Em nossa casuística, houve correlação negativa entre o tempo de doença e a densidade óssea apenas no colo do fêmur, não ocorrendo o mesmo nas outras regiões analisadas.…”

Section: Discussionunclassified

Estudo da densidade óssea na esclerodermia sistêmica

Silva¹,

Szejnfeld²,

Assis³

et al. 1997

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

INTRODUÇÃOO envolvimento ósseo, em pacientes com esclerodermia sistêmica, caracteriza-se, geralmente, por reabsorção óssea, predominantemente das extremidades das falanges distais dos dedos das mãos e, mais raramente, dos pés e outras partes do esqueleto [1][2][3] . Também, já foi descrito, em pacientes com esclerodermia, principalmente em mãos, osteopenia localizada periarticular, que, nos estágios mais tardios da doença, pode estender-se por todo o membro comprometido [4][5][6] . A observação inicial, associando osteopenia generalizada à esclerodermia, foi feita por Serup et al.

show abstract

Circulating androgens in male patients suffering from systemic scleroderma

Cited by 6 publications

References 11 publications

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis

Estudo da densidade óssea na esclerodermia sistêmica

Contact Info

Product

Resources

About