Circulating and Uteroplacental Adipocytokine Concentrations in Preeclampsia

Herse, Florian; Youpeng, Bai; Staff, Anne Cathrine; Yong-Meid, Jiang; Dechend, Ralf; Zhou, Rong

doi:10.1177/1933719109332828

Cited by 35 publications

(19 citation statements)

References 31 publications

(44 reference statements)

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“…Impaired placental development due to reduced trophoblast invasion is associated with PE and intra-uterine growth restriction. Altered plasma adiponectin concentrations have been described in women with PE (Takemura et al 2006a, Nien et al 2007, Fasshauer et al 2008, Herse et al 2009) reinforcing its possible implication on the control of trophoblast invasion.…”

Section: Discussionmentioning

confidence: 91%

Effects of adiponectin on human trophoblast invasion

Benaîtreau¹,

Santos²,

Leneveu³

et al. 2010

Journal of Endocrinology

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Adiponectin is an adipokine with insulin-sensitizing, antiinflammatory, anti-atherogenic, and anti-proliferative effects. The expression of specific adiponectin receptors in the placenta and in the endometrium suggests a role for this cytokine in placental development, but this role has not yet been elucidated. The invasion of trophoblast cells during the first trimester of pregnancy being crucial to placentation process, we have studied adiponectin effects on human trophoblast invasive capacities. We found that adiponectin stimulated human trophoblast cell migration in HTR-8/SVneo cells in a dose-independent manner. In addition, adiponectin also significantly enhanced invasion of HTR-8/SVneo cells and of human extravillous trophoblast from first trimester placenta. These pro-invasive effects of adiponectin in human trophoblasts seem to be mediated in part via increased matrix metalloproteinases (MMP2 and MMP9) activities and via repression of TIMP2 mRNA expression. Our results suggest that adiponectin could be a positive regulator of the early invasion process by modulating the MMP/TIMP balance. Moreover, these results provide an insight into the role of adiponectin in pathological conditions characterized by insufficient or excessive trophoblast invasion.

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Section: Discussionmentioning

confidence: 91%

Effects of adiponectin on human trophoblast invasion

Benaîtreau¹,

Santos²,

Leneveu³

et al. 2010

Journal of Endocrinology

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“…Our preliminary study also indicated that plasma adiponectin in preeclamptic patients was significantly lower than in normal pregnant women. 2 Although the studies about serum adiponectin level in preeclampsia and normal pregnancy are not consistent, significant differences have been seen between normal pregnancies and preeclampsia cases. This finding suggested to us that adiponectin could regulate vascular endothelial cell function during normal pregnancy and might be involved in the pathogenesis of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prevention and management of preeclampsia are difficult, especially in severe cases, because the etiology and pathogenesis of preeclampsia are unclear. Recent studies indicate that the interaction of adiponectin and its receptors might have a considerable role in the pathogenesis of preeclampsia [2][3][4] because of their important physiological functions, including anti-inflammatory, anti-atherosclerotic, vascular endothelial cell protection and insulin-sensitizing effects. [5][6][7][8] Numerous single-nucleotide polymorphisms (SNPs) exist in the human adiponectin gene, located on chromosome 3q27.…”

Section: Introductionmentioning

confidence: 99%

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

et al. 2010

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The etiology and pathogenesis of preeclampsia remain unclear. Little is known about the possible impact of adiponectin gene polymorphisms on the pathogenesis of preeclampsia. In this study, we analyzed the association of two adiponectin singlenucleotide polymorphisms (SNPs) with preeclampsia. One hundred eighty-eight Han Chinese pregnant women were enrolled (81 normal-term, 20 mild preeclampsia and 87 severe cases). Serum adiponectin level, and adiponectin exon 2 SNP +45T/G (rs2241766) genotype and intron 2 SNP +276G/T genotype (rs1501299) and their allele distributions were tested with enzyme-linked immunosorbent assay and PCR-restriction-fragment length polymorphism, respectively. There were no significant differences among the three groups (P40.05) in genotype distribution or allele frequencies of either SNP. Systolic pressure and 24-h urinary protein were lower in TT homozygotes than those in TG+GG patients at SNP +45T/G in the severe preeclamptic group (Po0.05). Furthermore, blood pressure, serum adiponectin level and 24-h urinary protein were lower in GG homozygotes than those in TG+TT patients at SNP +276G/T in the severe preeclamptic group (Po0.05). The risk of high blood pressure (X160/110 mm Hg) and of high serum adiponectin in T-allele carriers at +276G/T in the severe preeclamptic group were 5.345 and 5.818 times higher, respectively, compared with GG patients. These data suggest that adiponectin +45T/G and +276G/T polymorphisms are associated with important clinical manifestations of preeclampsia and that polymorphism +276G/T is associated with serum adiponectin level. Taken together, these findings suggest that adiponectin gene polymorphism is involved in the pathogenesis of preeclampsia.

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“…3 Thus, a dysregulation in leptin levels may indicate or lead to maternal disease. For example, placental leptin expression 4, 5 and circulating leptin levels 4, 6–9 are exaggerated in preeclampsia, a systemic maternal disease characterized by the new onset of hypertension and proteinuria after 20 weeks of gestation. 10 As the only treatment for preeclampsia is delivery of the placenta, 10 which is often preterm, there is a need to identify biomarkers for early prediction or to identify women with severe subtypes who require different clinical management.…”

Section: Introductionmentioning

confidence: 99%

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

Taylor

Ness²,

Olsen

et al. 2015

Hypertension

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Leptin, an adipocyte-derived hormone, plays an important role in reproduction and angiogenesis. Studies examining leptin in preeclampsia are inconsistent, possibly due to small sample sizes and variability in sampling and outcome. We conducted a nested case-control study to examine associations between serum leptin (measured: 9–26 weeks gestation) and preeclampsia among 430 primiparous preeclamptic women and 316 primiparous normotensive controls from the Danish National Birth Cohort. Median [interquartile range] leptin concentrations were calculated. Associations between leptin and preeclampsia (blood pressure ≥ 140/90mmHg), term preeclampsia (preeclampsia and delivery ≥ 37 weeks gestation), or preterm (preeclampsia and delivery < 37 weeks gestation) preeclampsia were examined using generalized linear models adjusting for body mass index, gestational age at blood draw, maternal age, smoking, and socio-occupational status. As leptin is increased in obese women and the risk of preeclampsia increases with body mass index, we used the Sobel test to examine if leptin is a mediator of this relationship. After adjustments, leptin concentrations were significantly higher in women with preeclampsia [30.5(24.6) p=0.0117] and term preeclampsia [30.4(24.9) p=0.0228] compared to controls [20.9(28.3)]. There was no significant difference between preterm preeclampsia [30.6(23.4) p=0.2210] and controls. Leptin is a possible mediator of the association between body mass index and preeclampsia (p=0.0276). Leptin concentrations are higher in women with preeclampsia compared to normotensive controls and may mediate some of the relationship between body mass index and preeclampsia.

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Circulating and Uteroplacental Adipocytokine Concentrations in Preeclampsia

Abstract: Adiponectin increases in normal pregnancy but remains correlated with prepregnancy body mass index. Plasma leptin decreases in normal pregnancy. In preeclamptic women, the normal adipokine responses are perturbed and this could be of pathophysiological significance.

Cited by 35 publications

References 31 publications

Effects of adiponectin on human trophoblast invasion

Effects of adiponectin on human trophoblast invasion

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

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