Circulating and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients

Okushi, Yuki; Okino, Kazuaki; Mukai, Kiyotaka; Matsui, Yoshihiko; Hayashi, Norifumi; Fujimoto, Keiji; Adachi, Hisashi; Yamaya, Hideki; Yokoyama, Hitoshi

doi:10.1007/s10157-016-1378-1

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…HLA-G was highly expressed in more than half of the biopsy samples. Crispim et al [23] detected HLA-G in 54.8% of biopsy samples, while Okushi et al [28] employed immunofluorescence and noted HLA-G expression in 34.37% of the samples. Considering these findings, the expression of HLA-G in our samples was significant.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical implications of HLA-G and PD-L1 following kidney transplantation: A cohort study

Botelho,

Wastowski,

Simões

et al. 2023

Medicine

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Kidney transplantation (KT) is the preferred treatment for end-stage renal diseases. Human leukocyte antigen G (HLA-G) and programmed death-ligand 1 (PD-L1) have notable clinical and therapeutic significance in transplantation because of their roles in promoting tolerance. This study aimed to assess HLA-G and PD-L1 levels at various stages following KT. A cohort of 12 patients was monitored from the pretransplant phase to 12 months post-surgery. Blood samples were taken at specific intervals: before kidney transplantation (T0), and then on the 7th (T7), 30th (T30), 90th (T90), 180th (T180), and 365th days post transplantation. Renal biopsies were performed in patients with graft dysfunction. Plasma levels of soluble HLA-G (sHLA-G) and PD-L1 were quantified using enzyme-linked immunosorbent assays. Additionally, immunohistochemistry was used to detect the presence of both molecules in biopsy samples. Multivariate analysis indicated that episodes of rejection were correlated with decreased expression of sHLA-G (P < .001) and PD-L1 (P < .001). Over the course of the study, the sHLA-G levels also declined (P < .001). Patients who had been transfused had lower PD-L1 levels (P = .03). Furthermore, kidney recipients from related live donors had increased HLA-G expression (P < .001). Our findings suggest that diminished HLA-G and PD-L1 levels correlate with an increased risk of graft rejection. Notably, HLA-G expression significantly decrease after the third-month posttransplantation.

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Section: Discussionmentioning

confidence: 99%

Expression and clinical implications of HLA-G and PD-L1 following kidney transplantation: A cohort study

Botelho,

Wastowski,

Simões

et al. 2023

Medicine

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“…Malignant cells typically develop mechanisms to evade immune surveillance [23]. HLA class I downregulation and HLA-G overexpression play critical roles in the modulation of immune responses against tumors.…”

Section: Hla-g and Cancermentioning

confidence: 99%

“…When immune-resistant variants are maintained and expanded, the evasion phase begins [24][25]. HLA-G molecules play crucial roles in all phases of immune editing by inhibiting the cytolytic action of NK cells and CTLs [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. HLA-G-positive tumors might progress from the elimination phase to the equilibrium phase through NK cell inhibition [26][27].…”

Section: Hla-g and Cancermentioning

confidence: 99%

HLA-G: Facts and Fictions

Shahraki

Alavianmehr

Farjadian

2018

Asian Pac J Cancer Biol

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Human leukocyte antigen (HLA)-G is a nonclassical MHC class I molecule with modulatory effects on NK and T cells. Unlike classical HLA class I molecules, HLA-G has seven isoforms, three of which are soluble. Soluble HLA-G molecules are reportedly able to transduce negative signals to immune cells after interacting with their corresponding receptors. The expression of these molecules plays significant roles in maternal tolerance against semi-allogenic fetuses. Overexpression of HLA-G in tumors and increased serum levels of soluble HLA-G have been reported in different malignancies, and these changes may be involved in tumoral immune evasion and cancer progression. To improve immune responses against tumor cells, the downmodulation of HLA-G by siRNA or blocking monoclonal antibodies can be helpful in cancer immunotherapy. Additionally, HLA-G can be considered a potential biomarker for the diagnosis and/or prognosis of certain cancers. Although polymorphism of the HLA-G gene-coding region is more limited than in classical HLA class I, some genetic variations in regulatory regions of the gene control the expression level of this molecule. Furthermore, epigenetic factors such as infections may affect the expression of HLA-G in infection-related cancers.

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“…So that, serum levels of soluble HLA‐G5 in renal transplant recipients who tolerated the allograft by a year is positively correlated with the median estimated glomerular filtration rate (eGFR). Moreover, patients with tubular HLA‐G1 and HLA‐G5 expressions have a better median eGFR (Okushi et al, ).…”

Section: Introductionmentioning

confidence: 99%

An update on potentials and promises of T cell co‐signaling molecules in transplantation

Mardomi

Mohammadi

Khosroshahi

et al. 2019

Journal Cellular Physiology

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Circulating and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients

Cited by 7 publications

References 26 publications

Expression and clinical implications of HLA-G and PD-L1 following kidney transplantation: A cohort study

Expression and clinical implications of HLA-G and PD-L1 following kidney transplantation: A cohort study

HLA-G: Facts and Fictions

An update on potentials and promises of T cell co‐signaling molecules in transplantation

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