Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

Földes, Gábor; Horkay, Ferenc; Szokodi, István; Vuolteenaho, Olli; Ilves, Mika; Lindstedt, Ken A.; Mäyränpää, Mikko I.; Sármán, Balázs; Serés, L.; Skoumal, Réka; Lakó-Futó, Zoltán; deChâtel, Rudolf; Ruskoaho, Heikki; Tóth, Miklós

doi:10.1016/s0006-291x(03)01424-4

Cited by 227 publications

(148 citation statements)

References 26 publications

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“…In our study, patients with and without CAD did not differ significantly in regard to calcium, ionized calcium, PTH, phosphate, Ca × P product, CRP, and apelin was related to none of these parameters (data not shown). Since chronic renal failure and chronic heart failure share a surprisingly large common ground of disease mechanism, our findings are in line with the study of Foldes et al [7] on the role of apelin in chronic heart failure. Szokodi et al [16] reported that apelin mRNA was markedly downregulated in cultured neonatal rat ventricular myocytes subjected to mechanical stretch and in vivo in two models of chronic ventricular pressure overload.…”

Section: Discussionsupporting

confidence: 93%

“…We also assessed apelin levels in 28 age- and sex-matched healthy volunteers and found that they were significantly higher than in hemodialyzed patients (84.00 ± 9.26 pg/ml vs. 49.16 ± 22.19 pg/ml, p < 0.001). Plasma apelin in our normal subjects were similar to values reported by Foldes et al [7] (89.8 ± 5.3 pg/ml, n = 6). In our study, we used the same assay as Foldes et al [7], specific for apelin-36 with no cross-reactivity to the shorter form, i.e.…”

Section: Discussionsupporting

confidence: 91%

“…Plasma apelin in our normal subjects were similar to values reported by Foldes et al [7] (89.8 ± 5.3 pg/ml, n = 6). In our study, we used the same assay as Foldes et al [7], specific for apelin-36 with no cross-reactivity to the shorter form, i.e. apelin-12 (detects the C-terminal part) as measured in other study [6].…”

Section: Discussionsupporting

confidence: 91%

“…It might suggest a role of apelin in cardiovascular pathology in renal failure. Left ventricular apelin mRNA levels were increased in heart failure and idiopathic dilated cardiomyopathy, whereas plasma apelin was decreased (71 ± 6 pg/ml) [7]. Moreover, the angiogenic activity of apelin [11] may participate in myocardial remodeling at the time of heart failure [12].…”

Section: Discussionmentioning

confidence: 99%

“…Early studies showed a decrease in blood pressure following intravenous bolus injection of apelin and a rise in heart rate in rats [6]. Foldes et al [7] demonstrated that apelin may contribute to the pathophysiology of human chronic heart failure. Ashley et al [8] reported that apelin reduced left ventricular preload, afterload and increased contractile reserve without evidence of hyperthrophy.…”

Section: Introductionmentioning

confidence: 99%

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Apelin and Cardiac Function in Hemodialyzed Patients: Possible Relations?

Małyszko

Kozminski³

et al. 2006

Am J Nephrol

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Background: Apelin, a newly discovered adipocytokine, is produced by white adipose tissue and is also expressed in the kidney and heart. Increasing evidence suggests a role for apelin in the pathology of the cardiovascular system. Cardiovascular disease is a major contributor to the mortality and morbidity in patients with chronic renal failure. The aim of this study was to assess associations between apelin, coronary artery disease (CAD) and echocardiographic parameters in hemodialyzed patients. Patients and Methods: We investigated plasma apelin levels (using commercially available kits) in 81 nondiabetic, clinically stable hemodialyzed patients (38 females, 43 males) with and without CAD. Results: Patients with CAD were significantly older, with significantly increased left ventricular internal end-diastolic dimension (LVIDd), left ventricular internal end-systolic dimension (LVISd), right ventricle (RV), left atrium (LA), interventricular septum in diastole, left ventricle posterior wall in diastole (LVPW), aorta, pulmonary artery, significantly lower ejection fraction and apelin than patients without CAD. We observed statistically significant correlations between apelin and echocardiographic parameters: LVIDd, LVISd, RV, LA, right atrium, LVPW, aorta, and serum lipids: cholesterol, LDL, triglycerides. In multiple logistic regression analysis, the only associate of apelin was LVIDd. Conclusions: Apelin level was significantly lower in dialyzed patients with CAD and it was associated with cardiac function. Apelin might be involved in the pathophysiology of cardiovascular disease in chronic renal failure. Since apelin is an inotrope in normal and failing hearts, this finding may have clinical implications for future use of apelin as a novel inotropic agent also for patients with uremic cardiomyopathy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apelin and Cardiac Function in Hemodialyzed Patients: Possible Relations?

Małyszko

Kozminski³

et al. 2006

Am J Nephrol

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Apelin and Vasopressin

Iturrioz

Goazigo

Moos

et al. 2008

Cardiovascular Hormone Systems

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The vascular footprint in cardiac homeostasis and hypertensive heart disease—A link between apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase

Iliev,

Gaydarski,

Kotov

et al. 2024

The Anatomical Record

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Recent studies have suggested a connection between disturbances of the apelin system and various cardiac pathologies, including hypertension, heart failure, and atherosclerosis. Vascular endothelial growth factor is crucial for cardiac homeostasis as a critical molecule in cardiac angiogenesis. Neuronal nitric oxide synthase is an essential enzyme producing nitric oxide, a key regulator of vascular tone. The present study aims to shed light upon the complex interactions between these three vital signaling molecules and examine their changes with the progression of hypertensive heart disease. We used two groups of spontaneously hypertensive rats and age‐matched Wistar rats as controls. The expression of the apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase were assessed immunohistochemically. We used capillary density and cross‐sectional area of the cardiomyocytes as quantitative parameters of cardiac hypertrophy. Immunoreactivity of the molecules was more potent in both ventricles of spontaneously hypertensive rats compared with age‐matched controls. However, capillary density was lower in both ventricles of the two age groups of spontaneously hypertensive rats compared with controls, and the difference was statistically significant. In addition, the cross‐sectional area of the cardiomyocytes was higher in both ventricles of the two age groups of spontaneously hypertensive rats compared with controls, and the difference was statistically significant. Our study suggests a potential link between the apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase in cardiac homeostasis and the hypertensive myocardium. Nevertheless, further research is required to better comprehend these interactions and their potential therapeutic implications.

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Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

Cited by 227 publications

References 26 publications

Apelin and Cardiac Function in Hemodialyzed Patients: Possible Relations?

Apelin and Cardiac Function in Hemodialyzed Patients: Possible Relations?

Apelin and Vasopressin

The vascular footprint in cardiac homeostasis and hypertensive heart disease—A link between apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase

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