Circulating Alpha-Tocopherol and Insulin Sensitivity Among Older Men With Chronic Kidney Disease

Xu, Hong; Xiong, Zhuo; Ärnlöv, Johan; Qureshi, Abdul Rashid; Cederholm, Tommy; Sjögren, Per; Lindholm, Bengt; Risérus, Ulf; Carrero, Juan Jesús

doi:10.1053/j.jrn.2015.11.005

Cited by 5 publications

(5 citation statements)

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“…21 The exogenous intake of antioxidants prevents inflammation, atherosclerosis, insulin resistance, and oxidative stress in CKD and dialysis patients. [22][23][24] Several clinical studies have examined the association between specific antioxidant micronutrients and CKD; however, the findings have been inconsistent. Some studies have suggested a negative correlation between the intake of vitamins A, C, and E, carotenoids, selenium, zinc and CKD, [25][26][27][28] whereas others showed no significant relationship.…”

Section: Discussionmentioning

confidence: 99%

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Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018

Wang,

Huang,

Zhu

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

“…21 The exogenous intake of antioxidants prevents inflammation, atherosclerosis, insulin resistance, and oxidative stress in CKD and dialysis patients. 22–24…”

Section: Discussionmentioning

confidence: 99%

Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018

Wang,

Huang,

Zhu

et al. 2023

Food Funct.

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“…The results of a meta-analysis suggest that short-term treatment with antioxidant vitamins can benefit patients with diabetes and albuminuria in terms of kidney function and systolic pressure; yet, such a treatment has no significant effect on glucose and lipid metabolism [66]. In multivariate regression analyses, Xu et al (2016) established that serum α-tocopherol levels are directly and strongly associated with insulin sensitivity index values [72]. Thus, the insufficiency of this antioxidant can significantly affect the course of DN.…”

Section: Discussionmentioning

confidence: 99%

Receiver Operator Characteristic (ROC) Analysis of Lipids, Proteins, DNA Oxidative Damage, and Antioxidant Defense in Plasma and Erythrocytes of Young Reproductive-Age Men with Early Stages of Type 1 Diabetes Mellitus (T1DM) Nephropathy in the Irkutsk Region, Russia

et al. 2022

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Oxidative stress plays a leading role in the pathogenesis of diabetic nephropathy. However, many aspects of oxidative stress reactions in the initial stages of this disease are not fully understood. The men cohort is of particular interest because of the severe effects of diabetes on their urogenital system. The aim of this study is to assess the intensity of lipids, proteins, DNA oxidative damage, blood antioxidant defense enzymatic, and activity of non-enzymatic components in men with type 1 diabetes mellitus (T1DM) in the early stages of diabetic nephropathy using receiver operator characteristic (ROC) analysis. This study included eighty-nine reproductive-age men in the initial stages of diabetic nephropathy (DN) and thirty-nine age- and sex-matched individuals not suffering from glycemic disorders. The DN patients were divided into two subgroups: stage 1 patients (urinary albumin < 30 mg/day and albumin/creatinine ratio < 3 mg/mmol (n = 45)) and stage 2 patients (urinary albumin 30–300 mg/day and albumin/creatinine ratio 3–30 mg/mmol (n = 44)). Levels of oxidative damage products (conjugated dienes (CDs), thiobarbituric acid reactants (TBARs), methylglyoxal (MGO), and 8-hydroxy-2’-deoxyguanosine (8-OHdG)) and antioxidants (glutathione peroxidase (GPx), glutathione S-transferases π (GSTp), glutathione reductase (GR), copper and zinc-containing superoxide dismutase 1 (SOD-1), total antioxidant status (TAS), α-tocopherol, retinol, reduced glutathione (GSH), and oxidative glutathione (GSSG)) were estimated in plasma and erythrocytes. Oxidative damage to cellular structures (higher values of median CDs (1.68 µmol/L; p = 0.003), MGO (3.38 mg/L; p < 0.001) in the stage 1 group and CDs (2.28 µmol/L; p < 0.0001), MGO (3.52 mg/L; p < 0.001), 8-OHdG (19.44 ng/mL; p = 0.010) in the stage 2 group) and changes in the antioxidant defense system (lower values of TAS (1.14 units; p = 0.011), α-tocopherol (12.17 µmol/L; p = 0.009), GPx (1099 units; p = 0.0003) and elevated levels of retinol (1.35 µmol/L; p < 0.001) in the group with stage 1; lower values of α-tocopherol (12.65 µmol/L; p = 0.033), GPx (1029.7 units; p = 0.0001) and increased levels of GR (292.75 units; p < 0.001), GSH (2.54 mmol/L; p = 0.010), GSSG (2.31 mmol/L; p < 0.0001), and retinol (0.81 µmol/L; p = 0.005) in the stage 2 group) were identified. The ROC analysis established that the following indicators have the highest diagnostic significance for stage 1 diabetic nephropathy: CDs (AUC 0.755; p < 0.0001), TBARs (AUC 0.748; p = 0.0001), MGO (AUC 0.720; p = 0.0033), retinol (AUC 0.932; p < 0.0001), GPx (AUC 0.741; p = 0.0004), α-tocopherol (AUC 0.683; p = 0.0071), and TAS (AUC 0.686; p = 0.0052) and the following for stage 2 diabetic nephropathy: CDs (AUC 0.714; p = 0.001), TBARs (AUC 0.708; p = 0.001), 8-OHdG (AUC 0.658; p = 0.0232), GSSG (AUC 0.714; p = 0.001), and GSH (AUC 0.667; p = 0.0108). We conclude that changes in indicators of damage to lipids, proteins, DNA, and the insufficiency of antioxidant defense factors already manifest in the first stage of diabetic nephropathy in men with T1DM. The ROC established which parameters have the greatest diagnostic significance for stages 1 and 2 of diabetic nephropathy, which may be utilized as additional criteria for defining men with T1DM as being in the risk group for the development of initial manifestations of the disease and thus allow for substantiating appropriate approaches to optimize preventive measures.

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“…Morimoto et al reported that polysulfone membranes coated with vitamin E exerted antioxidant activity via reducing ADMA in HD patients [85]. The goal of vitamin E supplementation is to increase α-tocopherol levels in plasma membranes, as it is a compound with the highest bioavailability in the class of vitamin E. In CKD patients, serum α-tocopherol levels are markedly decreased, suggesting an increased need for α-tocopherol in this population [86]. In terms of clinical benefits, α-tocopherol supplementation has been shown to reduce the risk of cardiovascular diseases and to increase erythrocyte antioxidants [87].…”

Section: Vitamins E and Cmentioning

confidence: 99%

Oxidative stress in chronic kidney disease

2018

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For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One of the main novel risk factors is oxidative stress, which occurs when there is overproduction of reactive oxygen species (ROS) and/or a reduction in antioxidant defense capacity. Oxidative stress is involved in the progression of renal injury, pathogenesis of atherosclerosis, and exacerbation of disease burden in CKD patients. In addition, uremic-and dialysis-associated factors in these patients further contribute to oxidative stress via a proinflammatory state, including exposure to dialysate endotoxins or the use of bioincompatible hemodialysis dialyzer membranes. Consequences of oxidative stress in CKD patients include atherosclerosis, amyloidosis, and anemia. Strategies to combat oxidative stress include antioxidant therapies such as vitamins C and E or N-acetylcysteine (NAC). While these antioxidant strategies are promising, few interventional studies have examined their effects until now. In light of the disparate experimental and clinical data, large, randomized, long-term studies are required to establish their efficacy and safety in CKD patients.

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Circulating Alpha-Tocopherol and Insulin Sensitivity Among Older Men With Chronic Kidney Disease

Cited by 5 publications

References 45 publications

Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018

Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018

Receiver Operator Characteristic (ROC) Analysis of Lipids, Proteins, DNA Oxidative Damage, and Antioxidant Defense in Plasma and Erythrocytes of Young Reproductive-Age Men with Early Stages of Type 1 Diabetes Mellitus (T1DM) Nephropathy in the Irkutsk Region, Russia

Oxidative stress in chronic kidney disease

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