Circulating alanine production and disposal in healthy subjects

Chochinov, R. H.; Perlman, K.; Moorhouse, John A.

doi:10.2337/diabetes.27.3.287

Cited by 21 publications

(17 citation statements)

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“…As summarized in Table 5, the synthesis of new alanine and glycine molecules accounts for about 6~~7 0 % of the whole body fluxes of the amino acids. Also, it is worth pointing out that the estimates of alanine flux given in this table agree with earlier values based on the use of I4C-alanine (Chochinov et al 1978) andalanine-2, d,-3, 3, 3, d, (Bier et al 1977) in healthy post-absorptive adult subjects.…”

Section: Response Of Amino Acid Metabolism To Intravenous Glucose Admsupporting

confidence: 88%

“…4), due probably to ingestion of the major energy yielding nutrients (carbohydrate), since this response to meal feeding was similar for diets providing quite different protein contents. In view of the significance of alanine in whole body glucose (Felig, 1973) and N metabolism (Chochinov et al 1978), it is evident that further studies of alanine metabolism under various dietary conditions would be instructive.…”

Section: Protein Metabolism In Man 349mentioning

confidence: 99%

“…https://doi.org/10.1079/PNS19810050 (Foster et al 1980). More recently, therefore, it has been suggested that the specific physiological function of the glucose-alanine cycle may be more concerned with ammonia or N transport (Chochinov et al 1978) than with glucose homoeostasis per se. Indeed, Lund (1981) has concluded that alanine is a major precursor of urea N. The associations among alanine, glucose and N metabolism are depicted in Fig.…”

Section: Response Of Amino Acid Metabolism To Intravenous Glucose Admmentioning

confidence: 99%

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Protein metabolism and nutritional state in man

1981

Proc. Nutr. Soc.

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Section: Response Of Amino Acid Metabolism To Intravenous Glucose Admsupporting

confidence: 88%

Section: Protein Metabolism In Man 349mentioning

confidence: 99%

Section: Response Of Amino Acid Metabolism To Intravenous Glucose Admmentioning

confidence: 99%

See 1 more Smart Citation

Protein metabolism and nutritional state in man

1981

Proc. Nutr. Soc.

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“…Although numerous studies have been carried out in vitro to investigate both the release of alanine by muscle (3)(4)(5)(6) and the uptake of the amino acid by the liver (7)(8)(9)(10), few such studies have been carried out in vivo. Chochinov et al (11,12) measured alanine flux in normal and diabetic subjects, while others have examined the effects of glucose infusion on splanchnic alanine uptake (13,14) but it is clear that a systematic examination of the effects of the various factors (insulin, glucagon, and glucose) that might influence alanine flux in the whole animal has not been carried out.…”

Section: Introductionmentioning

confidence: 99%

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

Shulman¹,

Lacy²,

Liljenquist³

et al. 1980

J. Clin. Invest.

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A B S T R A C Tpressed by 60±11 % after 2 h of hyperglycemia, and because this fall could not be entirely accounted for by decreased lactate extraction an inhibitory effect of glucose on gluconeogenesis within the liver is suggested. These studies indicate that the plasma glucose level per se can be an important determinant of the level of alanine and lactate in plasma as well as the rate at which they are converted to glucose.

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“…In the view of the significance of alanine metabolism in whole body glucose (50) and in nitrogen metabolism (51,52) (e.g. Fig.…”

Section: Approaches Taken With Stable Isotopesmentioning

confidence: 99%

Dynamics of human whole body amino acid metabolism: Use of stable isotope probes and relevance to nutritional requirements.

Young

1981

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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IntroductionAn improved definition of the requirements for nitrogen and indispensable amino acids in human protein nutrition depends upon a better understanding of the mechanisms responsible for, and nature of, the integration of protein and amino acid metabolism at the whole body level. Although the molecular and cellular events concerned with gene expression (e.g. 1, 2), the formation of tissue and organ proteins (3, 4) and their subsequent breakdown (5, 6) have been outlined, to some extent in great detail, in recent years, the relationships between these molecular, subcellular and organ-specific processes and the maintenance of nutritional status of the intact host remain to be vigorously explored. It is crucial that these relationships be defined if knowledge of protein and amino acid nutrition is to extend much beyond a stage that might be characterized, at present, as being rather empirical and, at times, almost naive. For this reason our research during the past few years has attempted to develop a more complete picture of the organization of whole body protein and amino acid metabolism and how it is affected by various nutritional and non-nutritional factors (e.g. 7-11).In this invited paper, some recent work that we have undertaken at MIT, also in collaboration with others, will be reviewed in order to explore, in greater depth, the physiology of body protein and amino acid metabolism in adult human subjects. Our purpose has been to try to determine how the nitrogen economy of the host is maintained under differing nutritional and physiological conditions.At the outset, it should be mentioned that although our work has been stimulated by many investigators a few of them deserve particular recognition; the

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Circulating alanine production and disposal in healthy subjects

Cited by 21 publications

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Protein metabolism and nutritional state in man

Protein metabolism and nutritional state in man

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

Dynamics of human whole body amino acid metabolism: Use of stable isotope probes and relevance to nutritional requirements.

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