Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

Abstract

Background Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors. Methods The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Study participants were classified into cardiometabolically healthy and unhealthy, where cardiometabolically healthy were those without hypertension, diabetes, and dyslipidemia. Fasting serum adiponectin levels were measured by radioimmunoassay. The omentin A326T (rs2274907) single nucleotide polymorphism (SNP) was screened by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Results The ‘A’ allele of the omentin SNP was significantly associated with lower adiponectin concentrations after adjusting for age, sex, body mass index (BMI), waist circumference (WC) and cardiometabolic health status (p = 1.90 x 10−47). There was also a significant association between circulating adiponectin concentrations and cardiometabolic health status after adjusting for age, sex, BMI, WC and Omentin SNP (p = 7.47x10-10). However, after adjusting for age, sex, BMI, WC and adiponectin levels, the association of ‘A’ allele with cardiometabolic health status disappeared (p = 0.79) suggesting that adiponectin serves as a mediator of the association between omentin SNP and cardiometabolic health status. There were no significant interactions between the SNP and dietary factors on adiponectin levels and cardiometabolic health status (p>0.25, for all comparisons). Conclusions Our findings show that adiponectin might function as a mechanistic link between omentin SNP and increased risk of cardiometabolic diseases independent of common and central obesity in Asian Indians. Before strategies to promote adiponectin modulation could be implemented, further studies are required to confirm the molecular mechanisms involved in this triangular relationship between omentin gene, adiponectin and cardiometabolic diseases.

Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis

“…Also, TT genotype carriers had significantly lower omentin relative expression as compared to that of RA patients with other genotypes. Current results support the hypothesis that the rs2274907 might be of functional relevance due to presence of highly conserved amino acid in its vicinity [41].…”

“…The rs2274907 (A326T) SNP lies within exon-4 of the omentin 1 gene, where at position 109, aspartate is exchanged with valine (Val109Asp or V109D). An association between omentin rs2274907 and T2D, obesity, and cardiometabolic diseases was previously reported [41].…”

“…Several studies provided evidence that polymorphisms in adipokines genes were associated with obesity, T2D and MetS risk [19,41,66]. We supposed that studied adipokines genes polymorphisms play a crucial role in RA pathogenesis.…”

Association of single nucleotide polymorphisms in ITLN1 gene with ischemic stroke risk in Xi’an population, Shaanxi province

“…ITLN1 variants have been implicated in various chronic diseases, such as human kidney stone disease ( Pungsrinont et al, 2021 ) and cardiovascular disease ( Al-Barqaawi et al, 2022 ; Vimaleswaran et al, 2021 ; Zhang et al, 2020 ). Nazar, Zehra & Azhar (2017) have discovered an association of ITLN1 Val109Asp with coronary heart disease in the Pakistani population ( Nazar, Zehra & Azhar, 2017 ) and the Turkish population ( Güçlü-Geyik et al, 2022 ).…”

“… Nazar, Zehra & Azhar (2017) have discovered an association of ITLN1 Val109Asp with coronary heart disease in the Pakistani population ( Nazar, Zehra & Azhar, 2017 ) and the Turkish population ( Güçlü-Geyik et al, 2022 ). The link between ITLN1 SNPs and cardiometabolic disease risk in Asian Indians has been evidenced by Vimaleswaran et al (2021) . Al-Barqaawi et al (2022) have investigated the effect of ITLN1 SNPs ( and ) on coronary artery disease risk in Iraqi individuals.…”