Circulating adiponectin levels are associated with peak oxygen uptake in Japanese

Miyatake, Nobuyuki; Numata, Takeyuki; Murakami, Haruka; Kawakami, Ryoko; Sanada, Kiyoshi; Tabata, Izumi; Miyachi, Motohiko

doi:10.1007/s12199-014-0390-x

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…Subjects were healthy Japanese men ( n = 376) and women ( n = 1025) aged 20–90 years, who were recruited from the community around the National Institute of Health and Nutrition (Tokyo, Japan) and randomly allocated to the following two groups: the development group (D group; 257 men, 913 women) and the cross-validation group (V group; 119 men, 112 women). This study was conducted as part of the Nutrition and Exercise Intervention Study (NEXIS) [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women

Furushima

Miyachi

Iemitsu

et al. 2017

J Physiol Anthropol

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BackgroundThis study aimed to develop and cross-validate prediction equations for estimating appendicular skeletal muscle mass (ASM) and to examine the relationship between sarcopenia defined by the prediction equations and risk factors for cardiovascular diseases (CVD) or osteoporosis in Japanese men and women.MethodsSubjects were healthy men and women aged 20–90 years, who were randomly allocated to the following two groups: the development group (D group; 257 men, 913 women) and the cross-validation group (V group; 119 men, 112 women). To develop prediction equations, stepwise multiple regression analyses were performed on data obtained from the D group, using ASM measured by dual-energy X-ray absorptiometry (DXA) as a dependent variable and five easily obtainable measures (age, height, weight, waist circumference, and handgrip strength) as independent variables.ResultsWhen the prediction equations for ASM estimation were applied to the V group, a significant correlation was found between DXA-measured ASM and predicted ASM in both men and women (R 2 = 0.81 and R 2 = 0.72). Our prediction equations had higher R 2 values compared to previously developed equations (R 2 = 0.75–0.59 and R 2 = 0.69–0.40) in both men and women. Moreover, sarcopenia defined by predicted ASM was related to risk factors for osteoporosis and CVD, as well as sarcopenia defined by DXA-measured ASM.ConclusionsIn this study, novel prediction equations were developed and cross-validated in Japanese men and women. Our analyses validated the clinical significance of these prediction equations and showed that previously reported equations were not applicable in a Japanese population.

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Section: Methodsmentioning

confidence: 99%

Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women

Furushima

Miyachi

Iemitsu

et al. 2017

J Physiol Anthropol

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“…Anthropometric parameters, physical activity measured using a tri-axis accelerometer, peak oxygen uptake, systolic BP (SBP), diastolic BP (DBP), cigarette smoking habit and energy intake according to a comprehensive brief-type selfadministered diet history questionnaire (BDHQ) were evaluated as previously described [23] in the NEXIS Study.…”

Section: Clinical Parametersmentioning

confidence: 99%

Circulating leptin levels are associated with physical activity or physical fitness in Japanese

Miyatake

Murakami

Kawakami

et al. 2014

Environ Health Prev Med

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Circulating leptin levels were 3.2 ± 2.3 ng/mL in men and 5.9 ± 3.8 ng/mL in women. Circulating leptin levels were significantly and positively correlated with body weight, body mass index, abdominal circumference, insulin and the homeostasis model assessment index, and significantly and negatively correlated with peak oxygen uptake in both sexes. Stepwise multiple regression showed that peak oxygen uptake in men and physical activity evaluated by Σ[metabolic equivalents h per week(METs h/w)]. in women were determinant factors for circulating leptin levels after adjusting for confounding factors.

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“…Adipokines are involved in glucose metabolism (e.g., adiponectin, leptin, resistin, visfatin, and PAI-1 [ 5 , 6 ]), inflammation (e.g., resistin and leptin [ 7 ]), reducing inflammation (e.g., adiponectin [ 5 , 7 ]), coagulation (e.g., PAI-1 [ 6 ]), endothelial dysfunction (e.g., PAI-1 [ 8 ]), and feeding behavior (e.g., leptin [ 6 ]). In addition, adiponectin augments energy expenditure [ 9 ]. With regard to epidemiological evidence, high concentrations of leptin [ 10 ], resistin [ 11 ], visfatin [ 12 ], and PAI-1 [ 8 , 13 ] have been associated with an increased risk of type 2 diabetes, whereas high adiponectin concentrations have been associated with a decreased risk of obesity [ 6 ] and type 2 diabetes [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines

et al. 2017

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BackgroundSaturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism.ObjectiveWe examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population.DesignA cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20–65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables.ResultsEven- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids.ConclusionsThe results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile.

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Circulating adiponectin levels are associated with peak oxygen uptake in Japanese

Cited by 9 publications

References 32 publications

Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women

Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women

Circulating leptin levels are associated with physical activity or physical fitness in Japanese

Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines

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