Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer:In Vivoandin VitroStudies

Abstract

Circulating adiponectin is independently and inversely associated with the risk of thyroid cancer. Human thyroid carcinomas and cell lines express adiponectin receptors. However, in the absence of a major direct effect of adiponectin on thyroid cancer cell lines in vitro, the negative association observed herein may be attributed to the metabolic effects of adiponectin.

Obesity and thyroid cancer

“…In 2011, Mitsiades and colleagues demonstrated that adiponectin levels are in serum inversely correlated with DTCs, exerting a protective effect against the development of this cancer. Furthermore, the authors demonstrated that thyroid tissues express ADIPOR1 and ADIPOR2, facilitating the entrance and the functioning of adiponectin in the thyroid (Mitsiades et al 2011), indicating that adiponectin is not only expressed, but also functional in thyroid cells. Another recent study has demonstrated that adiponectin receptors might be important for DTCs.…”

Changes in Thyroid Hormone Levels Within the Normal and/or Subclinical Hyper- or Hypothyroid Range Do Not Affect Circulating Irisin Levels in Humans

“…Ninety-six patients with a history of multi-nodular goiter or Graves' disease were originally recruited, as previously described (24). All participants had undergone total thyroidectomy and histology was negative for thyroid cancer.…”

“…However, since our studies are independent from each other, this does not have any impact on the statistical evaluations we conducted. In the cross-sectional study, Thyroid-Stimulating hormone (TSH), free Thyroxine (FT4) and free Trioidiothyronine (FT3) were measured using RIA as previously described (24). In the L-T4 Withdrawal study TSH, FT4 and total T3 were also measured using RIA (BRAHMS, GmbH, Hennigsdorf, Germany Samples from all studies were assayed for irisin by ELISA using the same, previously validated kit, which has been independently evaluated both at our laboratory (14) and .…”

Obesity and Thyroid Cancer: A Clinical Update

“…Although Cheng et al showed overexpression of its receptors in certain thyroid tumor types, this was linked to a better clinicopathological profile and improved outcomes (53). In a study in humans, Mitsiadis et al reported an inverse relation of circulating adiponectin levels with TC risk (54). The role of adipokines in the interplay between obesity and TC is an interesting subject of research and should be further explored.…”