Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus

Tsiotra, Panayoula C.; Halvatsiotis, Panagiotis; Patsouras, Konstantinos; Maratou, Eirini; Salamalekis, George; Raptis, Sotirios A.; Dimitriadis, George; Boutati, Eleni

doi:10.1016/j.peptides.2018.01.005

Cited by 53 publications

(57 citation statements)

References 57 publications

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“…We also found that RBP4 levels were positively correlated with CRP and IL-6. Recent studies have demonstrated that circulating leptin [30], adiponectin [31,32], and mild inflammation [33] could lead to exaggerated insulin resistance in GDM. Consistent with those findings, we also found that inflammation markers (CRP and IL-6) and adiponectin could predict increased risk of GDM.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Du¹,

Kong²

2018

Ann Nutr Metab

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Background: The aim of this study was to investigate whether retinol-binding protein 4 (RBP4) concentrations, measured at the first prenatal visit, are associated with risk of gestational diabetes mellitus (GDM). Methods: From July 2015 to June 2016, consecutive women who admitted to the obstetrics center of our hospital were included. At the first prenatal visit (the median gestational age was 6 [interquartile range 4–10] weeks) in the hospital, involved subjects were tested for fasting plasma glucose (FPG) and RBP4 using venous plasma samples collected after at least 8 h of fasting in the morning. Data for FPG and RBP4 concentrations at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation were collected and analyzed. Results: Blood at first prenatal visit was available for 827 women, among whom GDM developed in 101 (12.2%). In multivariate models comparing the second (Q2), third, and fourth quartiles against the first quartile of RBP4, concentrations of RBP4 in Q2, Q3, and Q4 were associated with GDM later developed, and increased risk of GDM by 54, 205, and 536%. There was a significant statistical difference in the area under the curve between the established risk factors alone and the addition of RBP4 concentrations (difference, 0.039 [95% CI 0.030–0.052]; p = 0.03). In the subgroup of women combined with obesity and FABP4 ≥median, the measured OR was 9.83 (95% CI [4.76–16.13]; p < 0.001) for GDM compared to those without obesity and FABP4

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Section: Discussionmentioning

confidence: 99%

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Du¹,

Kong²

2018

Ann Nutr Metab

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“…The specific, critical role that visceral adipose tissue alterations have in this pathophysiology, have hardly been addressed or not considered in great depth, thus far. However, recent data support the suggestion of an explicit part of VAT and visceral adiposity in GDM [18,[36][37][38][39]. Particularly, the expression of insulin receptor and adiponectin were found to be altered in GDM patients, accompanied by altered promoter methylation [16,17].…”

Section: Discussionmentioning

confidence: 71%

Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology

Rancourt

Ott

Ziska

et al. 2020

IJMS

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Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM. However, the impact visceral obesity and related epigenetics play for GDM etiopathogenesis have hardly been considered so far. Our recent findings within the prospective ‘EaCH’ cohort study of women with GDM or normal glucose tolerance (NGT), showed the role, critical factors of insulin resistance (i.e., adiponectin, insulin receptor) may have for GDM pathophysiology with epigenetically modified expression in subcutaneous (SAT) and visceral (VAT) adipose tissues. Here we investigated the expression and promoter methylation of key inflammatory candidates, tumor necrosis factor-alpha (TNF-α) and suppressor of cytokine signaling 3 (SOCS3) in maternal adipose tissues collected during caesarian section (GDM, n = 19; NGT, n = 22). The mRNA expression of TNF-α and SOCS3 was significantly increased in VAT, but not in SAT, of GDM patients vs. NGT, accompanied by specific alterations of respective promoter methylation patterns. In conclusion, we propose a critical role of VAT and visceral obesity for the pathogenesis of GDM, with epigenetic alterations of the expression of inflammatory factors as a potential factor.

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“…Increased maternal BMI is found to mediate inflammatory response during GDM 39&40 which may play part in altering the maternal normal regulation of insulin signalling and glucose transport 40 . Recent study has shown possible role of chimerin and leptin and their adipose tissue expression in mediating insulin resistance condition and inflammatory state in GDM accompanied by obesity 41 .…”

Section: Discussionmentioning

confidence: 99%

The association of maternal age, body mass index, physical activity with Gestational Diabetes Mellitus

Hazrat

Ahmed

Noushad

2018

Int. j. endorsing health sci. res.

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Background: Gestational diabetes mellitus (GDM) represents the state of carbohydrate intolerance during gestation. GDM is found as a risk factor for adverse outcomes of gestation concerning maternal and fetal health conditions. Increasing maternal age is found associated with GDM and also other obstetric complications. High maternal weight is reported to be linked to elevated risk of GDM. Relation of increased maternal age and elevated body mass index (BMI) state with GDM suggests a need of effective measures for improving the maternal and fetal health conditions and alienate the GDM associated obstetric concerns. Previous studies have found possible role of physical activity and exercise in reducing the risk of GDM development. This study aimed to explore GDM prevalence among participants and to perform comparative analysis of maternal age and BMI between participants without GDM and participants with GDM. Methodology: This cross-sectional study was conducted from March 2014 to September 2014, participants (n=133) filled in a questionnaire which aimed to assess parameters like age, BMI and physical activity for the study. Women in gestation were randomly invited to participate in study, and informed signed consent was obtained from each participant prior participation. Participants were categorized in two groups, participants without GDM and with GDM. For each participant, maternal age, BMI and involvement in physical activities were recorded. Data were analysed using IBM SPSS Statistics 24. Results: Mean values of maternal age and BMI were found to be lower for participants without GDM as compared to that of participants with GDM. Participants without GDM reported to be involved in household activities, occupational activities and exercise whereas participants with GDM were found to be only involved in household activities. Conclusion: In conclusion, this study may suggest possible influence of maternal age in GDM. Moreover, in view of findings which indicated higher mean value of maternal BMI of participants with GDM compared to that of participants without GDM, and in view of physical activity state, weight management and healthy lifestyle may be encouraged.

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Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus

Cited by 53 publications

References 57 publications

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology

The association of maternal age, body mass index, physical activity with Gestational Diabetes Mellitus

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