Circular RNAs: New Players in Cardiomyopathy

Abstract

Cardiomyopathies comprise a heterogeneous group of cardiac diseases identified by myocardium disorders and diminished cardiac function. They often lead to heart failure or heart transplantation and constitute one of the principal causes of morbidity and mortality worldwide. Circular RNAs (circRNAs) are a novel type of noncoding RNAs. They are covalently closed and single-stranded and derived from the exons and introns of genes by alternative splicing. This specific structure renders them resistant to exonuclease digestion. Many recent studies have demonstrated that circRNAs are highly abundant and conserved and can play central roles in biological functions such as microRNA (miRNA) sponging, splicing, and transcription regulation. Emerging evidence indicates that circRNAs can play significant roles in cardiovascular diseases, including cardiomyopathies. In this review, we briefly describe the current understanding regarding the classification, nomenclature, characteristics, and function of circRNAs and report recent significant findings concerning the roles of circRNAs in cardiomyopathies. Furthermore, we discuss the clinical application potential of circRNAs as the therapeutic targets and diagnostic biomarkers of cardiomyopathies.

Circular RNAs Variously Participate in Coronary Atherogenesis

“…The detected circRNAs were considered non-functional or splicing by-products; however, with the development of high-throughput sequencing and bioinformatics approaches, it was found that circRNAs are highly expressed in all eukaryotic cells and perform certain functions [ 35 ]. Recent studies have shown that circRNAs are critical regulators of cell physiology and various pathologies by modulating gene expression [ 29 , 36 , 37 , 38 , 39 ].…”