Circular RNAs in Blood Malignancies

de, Olivia Perez; Rossi, Martina; Gorospe, Myriam

doi:10.3389/fmolb.2020.00109

Cited by 39 publications

(29 citation statements)

References 78 publications

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“…circRNAs generally work by titrating miRNAs binding to mRNAs, thus influencing transcript stability and translation with implications in cancer [ 97 ]. circRNAs are aberrantly expressed in different tumor types and have been associated with both tumor initiation and progression in solid and hematologic malignancies [ 98 , 99 , 100 ]. In laryngeal squamous cell carcinoma, abnormal expression of circRNAs strongly correlates with malignant behavior.…”

Section: Novel Regulators Of the Igf System And Their Impact In Camentioning

confidence: 99%

Novel Regulators of the IGF System in Cancer

2021

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The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia.

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Section: Novel Regulators Of the Igf System And Their Impact In Camentioning

confidence: 99%

Novel Regulators of the IGF System in Cancer

2021

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“…In other studies, performed by Huang et al, the circRNA circAF4 was identified as having an oncogenic role in MLL- rearranged leukemias [ 147 ]. More on the role of circRNAs in hematopoiesis and in hematological malignancies can be found [reviewed in [ 148 , 149 , 150 ].…”

Section: Other Classes Of Non-coding Rnas and Their Role In Progenmentioning

confidence: 99%

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Rodriguez

Paculova

Kogut

et al. 2021

IJMS

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Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.

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“…Circular RNAs (circRNAs) are a class of non-coding RNAs with closed ends covalently originating from splicing processes known as back-splicing [ 59 ]. Their circular structure makes them much more stable than normal ncRNAs and highly conserved between species [ 60 ].…”

Section: Circrnasmentioning

confidence: 99%

“…CircRNAs affect various cellular processes through the induction of mRNA transcription or through acting as sponges (ceRNAs) for some miRNAs [ 61 ]. Although their role in the hematopoietic compartment is increasingly being recognized, circRNAs’ expression and function related to CLL remain largely unclear [ 59 ]. Interestingly, the majority of circRNAs produced by plasma cells come from Immunoglobulin (Ig) genes [ 62 ], creating speculation on their possible differential functions in CLL related to IGHV H mutational status.…”

Section: Circrnasmentioning

confidence: 99%

Non-Coding RNAs: The “Dark Side Matter” of the CLL Universe

et al. 2021

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For many years in the field of onco-hematology much attention has been given to mutations in protein-coding genes or to genetic alterations, including large chromosomal losses or rearrangements. Despite this, biological and clinical needs in this sector remain unmet. Therefore, it is not surprising that recent studies have shifted from coded to non-coded matter. The discovery of non-coding RNAs (ncRNAs) has influenced several aspects related to the treatment of cancer. In particular, in chronic lymphocytic leukemia (CLL) the knowledge of ncRNAs and their contextualization have led to the identification of new biomarkers used to follow the course of the disease, to the anticipation of mechanisms that support resistance and relapse, and to the selection of novel targeted treatment regimens. In this review, we will summarize the main ncRNAs discovered in CLL and the molecular mechanisms by which they are affected and how they influence the development and the progression of the disease.

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Circular RNAs in Blood Malignancies

Cited by 39 publications

References 78 publications

Novel Regulators of the IGF System in Cancer

Novel Regulators of the IGF System in Cancer

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Non-Coding RNAs: The “Dark Side Matter” of the CLL Universe

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