Circular RNAs and thyroid cancer: Closed molecules, open possibilities

Shifman, B M; Platonova, Nadezhda; Vasilyev, Evgeny; Абдулхабирова, Ф. М.; Kachko, Vera A.

doi:10.1016/j.critrevonc.2022.103662

Cited by 7 publications

(5 citation statements)

References 94 publications

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“…Several research groups have analyzed the expression of circRNAs in TCs of different histotypes and correlated their expression with the patient's clinicopathological features, such as tumor size, locoregional and distant metastases, prognosis, and mortality. Recent reviews [34][35][36][37] reported these major results. Interestingly, the high stability of circRNAs and their possible detection in blood and other bodily fluids, such as saliva and urine, open the possibility of their evaluation for early and differential diagnosis of thyroid diseases.…”

Section: Circular Rnas (Circrnas)mentioning

confidence: 89%

“…Nevertheless, the biological function of most circRNAs is still unclear. Several studies have associated circRNA deregulated expression with several diseases, including cancer [36].…”

Section: Circular Rnas (Circrnas)mentioning

confidence: 99%

“…However, for a detailed description of the circRNAs altered in TC, we refer readers to recent reviews focused on this topic [34][35][36][37]39].…”

Section: Circular Rnas (Circrnas)mentioning

confidence: 99%

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Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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Among the thyroid neoplasias originating from follicular cells, we can include well-differentiated carcinomas, papillary (PTC) and follicular (FTC) thyroid carcinomas, and the undifferentiated anaplastic (ATC) carcinomas. Several mutations in oncogenes and tumor suppressor genes have already been observed in these malignancies; however, we are still far from the comprehension of their full regulation-altered landscape. Even if only 2% of the human genome has the ability to code for proteins, most of the noncoding genome is transcribed, constituting the heterogeneous class of noncoding RNAs (ncRNAs), whose alterations are associated with the development of several human diseases, including cancer. Hence, many scientific efforts are currently focused on the elucidation of their biological role. In this review, we analyze the scientific literature regarding the involvement of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and pseudogenes in FTC, PTC, and ATC. Recent findings emphasized the role of lncRNAs in all steps of cancer progression. In particular, lncRNAs may control progression steps by regulating the expression of genes and miRNAs involved in cell proliferation, apoptosis, epithelial–mesenchymal transition, and metastatization. In conclusion, the determination of the diagnosis, prognosis, and treatment of cancer based on the evaluation of the ncRNA network could allow the implementation of a more personalized approach to fighting thyroid tumors.

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Section: Circular Rnas (Circrnas)mentioning

confidence: 89%

“…Nevertheless, the biological function of most circRNAs is still unclear. Several studies have associated circRNA deregulated expression with several diseases, including cancer [36].…”

Section: Circular Rnas (Circrnas)mentioning

confidence: 99%

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Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Martino

Esposito

Capone

et al. 2022

Cancers

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“…We observed notable sex differences in the global burden of thyroid cancer between 1990 and 2019, with women consistently showing a higher disease burden than men, though the gap has narrowed over time [ 34 – 36 ]. Recent trends indicate an accelerated increase in the burden among men, possibly due to later diagnosis [ 37 ]. These findings highlight the need for gender-specific approaches in thyroid cancer prevention and treatment, emphasising risk factor awareness and the importance of regular screening for early detection [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Trends and projections of the global burden of thyroid cancer from 1990 to 2030

Hu,

Wu,

Jiang

2024

J Glob Health

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Background We aimed to explore the burden of thyroid cancer worldwide from 1990 to 2019 and to project its future trends from 2020 to 2030. Methods Based on annual data on thyroid cancer cases from 1990 to 2019 available in the Global Burden of Disease (GBD) database, we calculated the age-standardised incidence, death, and disability-adjusted life year (DALY) rates for thyroid cancer. We used the estimated annual percentage change (EPAC) to quantify the temporal trends in these age-standardised rates from 1990 to 2019 and applied generalised additive models to project the disease burden from 2020 to 2030. Results The global age-standardised incidence rate (ASIR) of thyroid cancer increased from 1990 to 2019, with a higher overall disease burden in women than in men at both study time points. The male-to-female ratios for the ASIR increased from 0.41 in 1990 to 0.51 in 2019, while the ratio for the age-standardised death rate (ASDR) increased from 0.60 to 0.82. The models predicted the United Arab Emirates would have the fastest rising trend in both the ASIR (estimated annual percentage changes (EAPC) = 4.19) and age-standardised DALY rate (EAPC = 4.36) in 2020–30, while Saint Kitts and Nevis will have the fastest rising trend in the ASDR (EAPC = 2.29). Meanwhile, the growth trends for the ASDR and age-standardised DALY rate are projected to increase across countries in this period. A correlation analysis of the global burden of thyroid cancer between 1990–2019 and 2020–30 showed a significant positive correlation between the increase in the ASIR and socio-demographic index (SDI) in low-SDI and low-middle-SDI countries. Conclusions The global burden of thyroid cancer is increasing, especially in the female population and in low-middle-SDI regions, underscoring a need to target them for effective prevention, diagnosis, and treatment.

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“…CircRNAs can also contain multiple MREs that regulate gene expression at the transcriptional and/or post-transcriptional level [50]. Because circular RNA sponges are characterized by high expression levels, stability, and many miRNA binding sites in their structure, they are likely to be more effective sponges than linear transcripts [69].…”

Section: Regulation Of Transcription Factorsmentioning

confidence: 99%

A Review and In Silico Analysis of Tissue and Exosomal Circular RNAs: Opportunities and Challenges in Thyroid Cancer

Toraih

Hussein

Fawzy

et al. 2022

Cancers

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Thyroid cancer (TC) is the most common endocrine tumor. The genetic and epigenetic molecular alterations of TC have become more evident in recent years. However, a deeper understanding of the roles these molecular changes play in TC tumorigenesis and progression is essential in developing a successful treatment strategy and improving patients’ prognoses. Circular RNAs (circRNAs), a family of non-coding RNAs, have been implicated in several aspects of carcinogenesis in multiple cancers, including TC. In the current review, we aimed to explore the clinical potential of circRNAs as putative diagnostic, prognostic, and therapeutic targets in TC. The current analyses, including genome-wide circRNA screening and functional enrichment for all deregulated circRNA expression signatures, show that circRNAs display atypical contributions, such as sponging for microRNAs, regulating transcription and translation processes, and decoying for proteins. Given their exceptional clinical advantages, such as higher stability, wider abundance, and occurrence in several body fluids, circRNAs are promising prognostic and theranostic biomarkers for TC.

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Circular RNAs and thyroid cancer: Closed molecules, open possibilities

Cited by 7 publications

References 94 publications

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Noncoding RNAs in Thyroid-Follicular-Cell-Derived Carcinomas

Trends and projections of the global burden of thyroid cancer from 1990 to 2030

A Review and In Silico Analysis of Tissue and Exosomal Circular RNAs: Opportunities and Challenges in Thyroid Cancer

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