Circular RNAs: An emerging precise weapon for diabetic nephropathy diagnosis and therapy

The m6A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential

“…Besides, they function as transcription regulators of target genes through interacting with RNA Pol II by a mechanism of cis-regulation. Finally, they serve as protein scaffolds to block protein function and inactivate related signaling pathways ( 56 , 57 ). Increasing studies have proved the aberrant expression of circRNAs in patients with diabetes complications, implying its feasibility as a diagnostic or prognostic biomarker for these diseases ( 58 , 59 ).…”

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

“…Non-coding RNAs refers to RNA molecules in the transcriptome that are not translated into proteins 8 . Circular RNA (circRNA), a predominant class of endogenous non-coding RNA molecules widely expressed in eukaryotic cells, plays roles in various physiological and pathological processes, including neurodegenerative diseases 9 , 10 , cardiovascular diseases 11 , 12 , metabolic diseases 13 , 14 , and cancers 15 - 18 . The present study provides a comprehensive summary of biological functions and regulatory mechanisms of circRNAs in HNSCC, examining their potential applications and clinical translational value in diagnosis, prognosis, and targeted therapy.…”