Circular RNAs Act as miRNA Sponges

Panda, Amaresh C.

doi:10.1007/978-981-13-1426-1_6

Cited by 808 publications

(530 citation statements)

References 75 publications

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“…Circular RNAs (circRNAs) are a class of RNA transcripts that do not contain an open reading frame to encoding proteins . Recently, accumulating evidence has indicated that circRNAs play a pivotal role in cancer progression by regulating gene expression at the levels of chromatin modification, transcriptional, and posttranscriptional regulation . Several studies have found that dysfunction of various circRNAs is closely related to the proliferation, apoptosis, migration, invasion, and drug resistance of tumor cells .…”

Section: Introductionmentioning

confidence: 99%

Retracted: Elevation of circular RNA circ‐POSTN facilitates cell growth and invasion by sponging miR‐1205 in glioma

Yang

Zhang

Chen³

et al. 2019

J of Cellular Biochemistry

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Glioma is the most common type of primary intracranial tumor. Dysregulation of circular RNAs (circRNAs) plays a critical role in multiple solid tumors. However, the expression profiles of circRNAs and their functions in glioma have been rarely studied. The current work aims to investigate the clinical significance of a novel circRNA, circ‐POSTN, in glioma and explore its biological functions and mechanisms in the progression of glioma. We found that circ‐POSTN was highly expressed in glioma tissue samples and cells. High circ‐POSTN expression was significantly linked to larger tumor size, higher World Health Organization grades, and shorter overall survival. Furthermore, silencing of circ‐POSTN in glioma cells could decrease cell growth, migratory and invasive potential, and induce cell apoptosis in LN229 cells. On the contrary, ectopically expressed circ‐POSTN induced the opposite effects in the U251 cell line. By bioinformatic prediction and luciferase reporter assay, we identified that miR‐1205 could be sponged by circ‐POSTN. Further rescue assays demonstrated that the oncogenic functions of circ‐POSTN are partly attributed to its regulation of miR‐1205 in glioma cells. Taken together, our data suggest that circ‐POSTN plays an oncogenic role in glioma progression and may serve as a novel therapeutic target in this deadly disease.

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Section: Introductionmentioning

confidence: 99%

Retracted: Elevation of circular RNA circ‐POSTN facilitates cell growth and invasion by sponging miR‐1205 in glioma

Yang

Zhang

Chen³

et al. 2019

J of Cellular Biochemistry

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“…miRNAs are endogenous non‐coding RNA molecule targeting the 3'UTR region of genes with a length of 18‐22 nt and can regulate gene expression at a post‐transcriptional level to degrade or inhibit the translation of target genes . However, the expression level of miRNAs also infected by its upstream molecular circRNAs, which are non‐coding RNA molecules that do not have a 5' cap end and a 3' tail and are covalently bonded to form a ring structure, and circRNAs act as miRNA sponge, which contains miRNA response elements and can bind to miRNA, preventing miRNA from inhibiting target genes, therefore up‐regulating corresponding gene expression . And due to its important role in cell information regulation, circRNAs have attracted much attention as new molecular markers in recent years …”

Section: Discussionmentioning

confidence: 99%

“…27 However, the expression level of miRNAs also infected by its upstream molecular circRNAs, which are non-coding RNA molecules that do not have a 5' cap end and a 3' tail and are covalently bonded to form a ring structure, and circRNAs act as miRNA sponge, which contains miRNA response elements and can bind to miRNA, preventing miRNA from inhibiting target genes, therefore up-regulating corresponding gene expression. 28 And due to its important role in cell information regulation, circRNAs have attracted much attention as new molecular markers in recent years. 29 In our study, we observed 9 miRNAs that target at least 2 genes which involved in cytokine signalling in immune system.…”

Section: F I G U R Ementioning

confidence: 99%

STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection

Zhang

et al. 2020

J Cellular Molecular Medi

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Tuberculosis (TB) is a severe infectious disease that seriously endangers human health. The immune defence mechanism of the body against TB is still unclear. The purpose of this study was to find the key molecules involved in the immune defence response during TB infection, and provide reference for the treatment of TB and further understanding of the immune defence mechanism of the body. Data from http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83456 were downloaded from GEO data sets for analysis, and a total of 192 differentially expressed genes were screened out. Most of these genes are enriched in the interferon signalling pathway and are defence response–related. We also found that STAT1 plays an important role in the immune defence of TB infection and it is one of the key genes related to interferon signalling pathway. STAT1‐related molecules including hsa‐miR‐448, hsa‐miR‐223‐3p, SAMD8_hsa_circRNA 994 and TWF1_hsa_circRNA 9897 were therefore screened out. Furthermore, expression levels of hsa‐miR‐448 and hsa‐miR‐223‐3p were then verified by qRT‐PCR. Results showed that both hsa‐miR‐448 and hsa‐miR‐223‐3p were down‐regulated in plasma from patients with pulmonary TB. Taken together, our data indicate that an mRNA‐miRNA‐circRNA interaction chain may play an important role in the infection of MTB, and STAT1 and related molecules including hsa‐miR‐223‐3p, has‐miR‐448, SAMD8_hsa_circRNA994 and TWF1_hsa_circRNA9897 were identified as potential biomarkers in the development of active TB.

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“…5 In breast cancer, circZNF609 promotes cell growth, migration and invasion via sponging miR-145-5p. 5 In breast cancer, circZNF609 promotes cell growth, migration and invasion via sponging miR-145-5p.…”

Section: Introductionmentioning

confidence: 99%

circEPSTI1 regulates ovarian cancer progression via decoying miR‐942

Xie

Wang

et al. 2019

J Cellular Molecular Medi

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Increasing studies show that circular RNAs (circRNAs) play vital roles in tumour progression. But, how circRNAs function in ovarian cancer is mostly unclear. Here, we detected the expression of circEPSTI1 in ovarian cancer and explored the function of circEPSTI1 in ovarian cancer via a series of experiments. Then, we performed luciferase assay and RNA immunoprecipitation (RIP) assay to explore the competing endogenous RNA (ceRNA) function of circEPSTI1 in ovarian cancer. qRT‐PCR verified that circEPSTI1 was overexpressed in ovarian cancer. Inhibition of circEPSTI1 suppressed ovarian cancer cell proliferation, invasion but promoted cell apoptosis. Luciferase assays and RIP assay showed that circEPSTI1 and EPSTI1 (epithelial stromal interaction 1) could directly bind to miR‐942. And circEPSTI1 could regulate EPSTI1 expression via sponging miR‐942. In summary, circEPSTI1 regulated EPSTI1 expression and ovarian cancer progression by sponging miR‐942. circEPSTI1 could be used as a biomarker and therapeutic target in ovarian cancer.

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Circular RNAs Act as miRNA Sponges

Cited by 808 publications

References 75 publications

Retracted: Elevation of circular RNA circ‐POSTN facilitates cell growth and invasion by sponging miR‐1205 in glioma

Retracted: Elevation of circular RNA circ‐POSTN facilitates cell growth and invasion by sponging miR‐1205 in glioma

STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection

circEPSTI1 regulates ovarian cancer progression via decoying miR‐942

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