Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling

Du, Senjie; Li, Hongying; Lu, Fei; Zhang, Shang; Tang, Jinshan

doi:10.7150/jca.54934

Cited by 19 publications

(20 citation statements)

References 45 publications

(45 reference statements)

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“…In order to better demonstrate the role and function of circRNAs, we listed 7 circRNAs that are currently mainly studied, including CDR1as [ 3 , [32] , [33] , [34] , [35] ], circFOXO3 [ [36] , [37] , [38] , [39] , [40] ], circHIPK3 [ [41] , [42] , [43] , [44] , [45] ], circITCH [ [46] , [47] , [48] , [49] , [50] ], circMTO1 [ [50] , [51] , [52] , [53] , [54] , [55] ], circSMARCA5 [ [56] , [57] , [58] , [59] , [60] ] and circZNF609 [ [61] , [62] , [63] , [64] , [65] ]. Moreover, we showed the top 5 most cited articles for these circRNAs ( Table 7 ).…”

Section: Resultsmentioning

confidence: 99%

“…These studies mainly involve cell biology, such as properties of circRNAs [ 32 ], cell cycle [ 36 ], cell apoptosis [ 38 ]and cell growth [ 41 ]; biological functions, such as miRNA sponge [ 3 ], brain function [ 33 , 35 ], insulin transcription and secretion [ 34 ], and cardiac senescence [ 37 ]. The main research area of these circRNAs is tumor study, including prostate cancer [ 39 , 40 , 57 ], bladder cancer [ 42 , 46 , 52 , 56 ], colorectal cancer [ 43 , 53 , 60 , 64 ], hepatocellular carcinoma [ 45 , 47 , 51 ], thyroid cancer [ 48 ], breast cancer [ 49 ], ovarian carcinoma [ 50 ], cervical cancer [ 54 ], lung adenocarcinoma [ 55 , 61 ], non-small cell lung cancer [ 58 ], multiple myeloma [ 59 ], cholangiocarcinoma [ 62 ], glioma [ 63 ], and gastric cancer [ 65 ]. Study of diabetes mellitus was also reported in one article [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hotspots and development frontiers of circRNA based on bibliometric analysis

Zhang

Kang

Kong

et al. 2022

Non-coding RNA Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hotspots and development frontiers of circRNA based on bibliometric analysis

Zhang

Kang

Kong

et al. 2022

Non-coding RNA Research

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“… 51 MiR-1224-3p/PLK1 and miR-1224-3p/ETV1 axes were modulated in circular RNA ZNF609-induced promotion of glioma and lung adenocarcinoma, respectively. 52 , 53 Hsa-miR-550a-3p downregulated TIMP2 and resulted in promoted non-small cell lung cancer cell proliferation and metastasis, 54 but it exerted antitumor effect in breast cancer by alleviating levels of ERK1 and ERK2. 55 …”

Section: Discussionmentioning

confidence: 99%

A Next-Generation Sequencing of Plasma Exosome-Derived microRNAs and Target Gene Analysis with a Microarray Database of Thermally Injured Skins: Identification of Blood-to-Tissue Interactions at Early Burn Stage

Li¹,

Cai²,

Yang³

et al. 2021

JIR

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Background Plasma exosome-derived microRNA (miRNA) profiles following thermal injury and their relationship with gene expression derangements in burned skin remain unexplored. This study focused on the identification of key miRNA-mRNA axes in potential blood-to-tissue interactions at early burn stage. Methods Plasma exosomes were obtained from 6 severe burn patients 4–7 days post injury and 6 healthy volunteers. Next-generation sequencing (NGS) of exosomal small RNAs presented the differentially expressed miRNAs (DEMs). Target genes of the DEMs were predicted in the mirDIP database. Dataset GSE8056 was enrolled to acquire differentially expressed genes (DEGs) in burned skin compared to normal skin. Overlap between the DEGs and target genes of the DEMs were focus genes. The protein–protein interaction (PPI) network and enrichment analyses of the focus genes demonstrated hub genes and suggested underlying mechanisms and pathways. The hub genes and upstream DEMs were selected to construct key miRNA-mRNA axes. Results The NGS of plasma exosome-derived small RNAs identified 85 DEMs (14 downregulated miRNAs and 71 upregulated miRNAs) with 12,901 predicted target genes. Dataset GSE8056 exhibited 1861 DEGs in partial-thickness burned skins 4–7 days postburn. The overlap between DEGs and target genes of DEMs displayed 1058 focus genes. The top 9 hub genes (CDK1, CCNB1, CCNA2, BUB1B, PLK1, KIF11, AURKA, NUSAP1 and CDCA8) in the PPI network of the focus genes pointed to 16 upstream miRNAs in DEMs, including 4 downregulated miRNAs (hsa-miR-6848-3p, has-miR-4684-3p, has-miR-4786-5p and has-miR-365a-5p) and 12 upregulated miRNAs (hsa-miR-6751-3p, hsa-miR-718, hsa-miR-4754, hsa-miR-6754-3p, hsa-miR-4739, hsa-miR-6739-5p, hsa-miR-6884-3p, hsa-miR-1224-3p, hsa-miR-6878-3p, hsa-miR-6795-3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). A key miRNA-mRNA network in potential blood-to-tissue interactions at early burn stage was therefore constructed. Conclusion An NGS and bioinformatic analysis in the study identified key miRNA-mRNA axes in potential blood-to-tissue interactions at early burn stage, suggesting plasma exosome-derived miRNAs may impact on the alteration patterns of gene expressions in a burn wound.

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“…Du et al 72 observed that circ‐ZNF609 was upregulated in glioma. Elevated circ‐ZNF609 expression led to increased migration and invasion of glioma cells both in vitro and in vivo whereas silencing circ‐ZNF609 decreased migration and invasion of glioma cells.…”

Section: Functions Of Circrnasmentioning

confidence: 99%

circ‐ZNF609: A potent circRNA in human cancers

Qian

Yang

et al. 2021

J Cellular Molecular Medi

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Circular RNAs (circRNAs) are a novel group of endogenous RNAs with a circular structure. Growing evidence indicates that circRNAs are involved in a variety of human diseases including malignancies. CircRNA ZNF609 (circ‐ZNF609), derived from the ZNF609 gene sequence, has been demonstrated to be involved in the development and progression of many diseases. circ‐ZNF609 is thought to be a viable diagnostic and prognostic biomarker for several diseases and might be a new therapeutic target, but further research is needed to accelerate clinical application. Here, we review the biogenesis and function of circRNAs and the functional roles and molecular mechanism related to circ‐ZNF609 in neoplasms and other diseases.

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Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling

Cited by 19 publications

References 45 publications

Hotspots and development frontiers of circRNA based on bibliometric analysis

Hotspots and development frontiers of circRNA based on bibliometric analysis

A Next-Generation Sequencing of Plasma Exosome-Derived microRNAs and Target Gene Analysis with a Microarray Database of Thermally Injured Skins: Identification of Blood-to-Tissue Interactions at Early Burn Stage

circ‐ZNF609: A potent circRNA in human cancers

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