Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling

Chen, Feifei; Guo, Lei; Di, Jiehui; Li, Man; Dong, Dong; Pei, Dong‐Sheng

doi:10.1016/j.jgg.2021.07.017

Cited by 22 publications

(13 citation statements)

References 45 publications

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“…The research group of Zhang et al (2021d) , Chen et al (2021) , and Xie et al (2021) , respectively, identified the upregulated circ_103948, circ_UBAP2, and circ_BANP in the CRC tissues and cells, and the following experiments proved that all the aforementioned circRNAs possessed the capability of promoting the colorectal cancer proliferation and metastasis. In particular, circBANP was shown to promote the radiation resistance of CRC.…”

Section: Main Textmentioning

confidence: 94%

Circular RNA-regulated autophagy is involved in cancer progression

Zhou

Lin

Wang

et al. 2022

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a sort of long, non-coding RNA molecules with a covalently closed continuous ring structure without 5'-3' polarity and poly-A tail. The modulative role of circRNAs in malignant diseases has been elucidated by many studies in recent years via bioinformatics and high-throughput sequencing technologies. Generally, circRNA affects the proliferative, invasive, and migrative capacity of malignant cells via various mechanisms, exhibiting great potential as novel biomarkers in the diagnoses or treatments of malignancies. Meanwhile, autophagy preserves cellular homeostasis, serving as a vital molecular process in tumor progression. Mounting studies have demonstrated that autophagy can not only contribute to cancer cell survival but can also induce autophagic cell death in specific conditions. A growing number of research studies have indicated that there existed abundant associations between circRNAs and autophagy. Herein, we systemically reviewed and discussed recent studies on this topic in different malignancies and concluded that the circRNA–autophagy axis played crucial roles in the proliferation, metastasis, invasion, and drug or radiation resistance of different tumor cells.

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Section: Main Textmentioning

confidence: 94%

Circular RNA-regulated autophagy is involved in cancer progression

Zhou

Lin

Wang

et al. 2022

Front. Cell Dev. Biol.

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“…Circ ubiquitin-associated protein 2 (circ UBAP2) upregulates forkhead transcription factor O1 (FOXO1). Circ UBAP2 (Figure 7) was up-regulated in CRC tissues and cell lines and induced autophagy in vitro and in vivo (203). Down-regulation of circ UBAP2 in CRC cell lines impeded proliferation, migration, and invasion.…”

Section: Circ Rnas Up-regulating Forkhead-box Family Transcription Fa...mentioning

confidence: 96%

Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets

Weidle

Nopora

2023

Cancer Genomics Proteomics

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“…Since circRNAs do not have a free 5′ or 3′ end, they are stable and have a long half‐life and are not easily degraded by RNase R, which makes them promising as biomarkers 12,13 . Recent findings have suggested that circRNAs are abnormal in tumor tissues 14 and are capable of participating in a variety of biological processes in cancerous cells 15,16 . For example, circ‐MBOAT2 promoted pancreatic cancer progression via miR‐433‐3p/GOT1 signaling 17 .…”

Section: Introductionmentioning

confidence: 99%

“…12 , 13 Recent findings have suggested that circRNAs are abnormal in tumor tissues 14 and are capable of participating in a variety of biological processes in cancerous cells. 15 , 16 For example, circ‐MBOAT2 promoted pancreatic cancer progression via miR‐433‐3p/GOT1 signaling. 17 Circ_0124554 blocked the ubiquitination of AKT and facilitated lymphovascular infiltration in colorectal cancer liver metastasis.…”

Section: Introductionmentioning

confidence: 99%

Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR‐6838‐5p

et al. 2023

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Background: An increasing number of circular RNAs (circRNAs) have been shown to play an important role in the tumorigenesis of breast cancer. The aim of this study was to investigate the expression and function of circ_0001667 and its potential molecular mechanisms in breast cancer. Methods: The expression levels of circ_0001667, miR-6838-5p and CXC chemokine ligand 10 (CXCL10) in breast cancer tissues and cells were detected by quantitative real-time PCR. Cell counting kit-8 assay, EdU assay, flow cytometry, colony formation and tube formation assays were used to detect cell proliferation and angiogenesis. The binding relationship between miR-6838-5p and circ_0001667 or CXCL10 was predicted using the starBase3.0 database and verified by dual-luciferase reporter gene assay, RIP and RNA pulldown. Animal experiments were performed to assess the function of circ_0001667 knockdown on breast cancer tumor growth. Results: Circ_0001667 was highly expressed in breast cancer tissues and cells, and its knockdown inhibited proliferation and angiogenesis of breast cancer cells. Circ_0001667 sponged miR-6838-5p, and inhibition of miR-6838-5p reversed the inhibitory effect of silencing circ_0001667 on proliferation and angiogenesis of breast cancer cells. MiR-6838-5p targeted CXCL10, and overexpression of CXCL10 reverses the effect of miR-6838-5p overexpression on breast cancer cell proliferation and angiogenesis. In addition, circ_0001667 interference also reduced breast cancer tumor growth in vivo. Conclusion: Circ_0001667 is involved in breast cancer cell proliferation and angiogenesis through regulation of the miR-6838-5p/CXCL10 axis.

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Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling

Cited by 22 publications

References 45 publications

Circular RNA-regulated autophagy is involved in cancer progression

Circular RNA-regulated autophagy is involved in cancer progression

Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets

Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR‐6838‐5p

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