Circular RNA SMARCA5 inhibits gastric cancer progression through targeting the miR-346/ FBXL2 axis

Abstract

Circular RNA (circRNA) SMARCA5 (circSMARCA5) is a cancer-related circRNA that has been observed to be involved in the progression of several types of cancer.

CircSMARCA5: A key circular RNA in various human diseases

“…Cai et al evaluated circSMARCA5 levels in 60 pairs of GC tissues and matched paracancerous tissues and the circSMARCA5 levels were remarkably reduced in cancer tissues compared to paired normal tissues ( Cai and Zuo, 2019 ). These findings were similar to those of Li et al ( Li and Hu, 2019 ) Similarly, the plasma circSMARCA5 expression level in GC patients was also reduced compared with that in healthy controls. Moreover, circSMARCA5 in plasma remained stable under some harsh conditions ( Cai and Zuo, 2019 ).…”

“…Several studies have reported that circSMARCA5 levels in HCC tissues are lower than those in matched normal tissues ( Yu et al, 2018 ; Zhang et al, 2018 ; Li and Hu 2019 ). Moreover, the abundance of circSMARCA5 in plasma and tissues gradually decreases from healthy controls to hepatitis patients, cirrhosis patients and HCC patients, which indicates that circSMARCA5 expression is tissue-stage specific.…”

“…Moreover, circSMARCA5 in plasma remained stable under some harsh conditions ( Cai and Zuo, 2019 ). Functional experiments were also performed, showing that circSMARCA5 overexpression notably suppressed GC cell proliferation, migration, and invasion ( Cai and Zuo, 2019 ; Li and Hu, 2019 ).…”

“…Furthermore, the clinicopathological features of GC, such as the degree of tumor differentiation, lymph node metastasis, vascular invasion and AJCC stage, were negatively associated with the level of circSMARCA5 ( Cai and Zuo, 2019 ). Mechanistically, circSMARCA5 inhibits GC progression by serving as a sponge of miR-346 to upregulate FBXL2 expression ( Li and Hu 2019 ). Kaplan-Meier analysis demonstrated that patients with low circSMARCA5 expression had worse overall survival (OS) and disease-free survival (DFS).…”

The Biological Role of Sponge Circular RNAs in Gastric Cancer: Main Players or Coadjuvants?

“…A large number of studies have demonstrated the role of circRNAs as miRNA-sponges in GC [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. For example, it has been shown that alterations in circLARP4/miR-424/LATS1 [ ...…”