Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Tang, Ying; Bao, Jinghui; Jiahui, HU; Liu, Leiling; Xu, Danyan

doi:10.1111/jcmm.16203

Cited by 44 publications

(34 citation statements)

References 67 publications

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“…CircRNAs are abundant, endogenous, stable, conserved, and cell-type specific molecules, which could participate in regulating cell function ( Kristensen et al, 2019 ). Increasing attention has focused on functions for circRNAs in human diseases, such as neurological diseases (W. Han et al, 2018 ; Chen et al, 2020a ), cardiovascular disease ( Zhang et al, 2020a ; Tang et al, 2021 ), diabetes mellitus ( Zhang et al, 2020b ; Zaiou, 2020 ), and tumorigenesis ( Goodall and Wickramasinghe, 2021 ; G. ; Huang et al, 2020b ), especially cardiovascular diseases. For instance, Garikipati et al found that circRNAs were altered expressed in the mouse model of post myocardial infarction (MI) ( Garikipati et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis

Lai

Chen

Zhan³

et al. 2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) participate in the development of various kinds of diseases. However, the function and roles of circRNAs in obstructive sleep apnea (OSA)-induced cardiovascular disease remain poorly understood. Therefore, we sought to explore the circRNA expression profiles and predict their functions in OSA-induced cardiac injury with the use of bioinformatics analysis. The model of OSA was established in mouse treated by chronic intermittent hypoxia (CIH) exposure. Then, we screened the circRNA profile using circRNA microarray. By comparing circRNA expression in three matched pairs of CIH-treated cardiac tissues and controls, differentially expressed circRNAs were identified in the CIH groups. Comparison of the selected circRNAs expression levels was performed between qRT-PCR and microarray. Meanwhile, we employed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses to predict the functions of these selected circRNAs. Finally, we constructed a circRNA-miRNA-mRNA network based on the target prediction. It was found that a total of 124 circRNAs were differentially expressed in CIH-treated cardiac tissues (p ≤ 0.05, fold-change ≥ 1.5). Among them, 23 circRNAs were significantly down-regulated, and the other 101 were up-regulated. Then, ten circRNAs were randomly selected to validate the reliability of the microarray results by using qRT-PCR. Next, we conducted the GO and KEGG pathway analysis to explore the parental genes functions of differentially expressed circRNA. Finally, two significantly differentially expressed circRNAs (mmu_circRNA_014309 and mmu_circRNA_21856) were further selected to create a circRNA-miRNA-mRNA regulation network. Our study did first reveal that the differentially expressed circRNAs played a vital role in the pathogenesis of OSA-induced cardiac damage. Thus, our findings bring us closer to unraveling the pathophysiologic mechanisms and eliciting novel therapeutic targets for the treatment of OSA-associated cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis

Lai

Chen

Zhan³

et al. 2021

Front. Cell Dev. Biol.

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“…Research has shown that circRNAs function as pivotal regulators in various physiological and pathological activities. Further, their circular conformation endows them with a unique ribonuclease-resistant character not possessed by their linear counterparts, making them ideal biomarkers and treatment targets (10).…”

Section: The Biogenesis Characteristics and Functions Of Circrnasmentioning

confidence: 99%

“…Circular ribonucleic acids (circRNAs), the newly discovered non-coding RNAs, have been the subject of extensive research in different types of diseases, such as lung cancers, neurological disorders, and cardiovascular diseases (8)(9)(10). Numerous studies have shown that circRNAs are pivotal regulators in bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs as potential regulators in bone remodeling: a narrative review

Pan¹,

Cen²,

Zhang³

et al. 2021

Ann Transl Med

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In this review, we focus on the recent progress of circular ribonucleic acids (circRNAs)-related molecular mechanisms in the processes of osteogenesis and osteoclastogenesis, and explore their roles in the development of bone-remodeling disorders.Background: The well-coupled bone-formation and bone-resorption processes are vital in bone remodeling. Once the balance is disrupted, bone-remodeling disorders (e.g., osteoporosis and osteopetrosis) occur, severely affecting patients' quality of life. CircRNAs, the newly discovered members of the noncoding RNA family, have been reported to act as key checkpoints of various signaling pathways that influence osteoblasts and osteoclasts functions, thus regulating the physiological and pathological processes of bone homeostasis.Methods: Three English and three Chinese databases [i.e., PubMed, Embase, MEDLINE (via Ovid), Chinese Biomedical Literature, China National Knowledge Infrastructure, and VIP databases] were searched to June 2021 without language restrictions. Studies exploring the roles of circRNAs in key bone remodeling mediators, such as Smad-dependent bone morphogenetic protein (BMP)/transforming growth factor beta (TGF-β), Wnts, runt-related transcription factor (RUNX), forkhead boxes (FOXs), colony-stimulating factor 1 (CSF-1), receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), and circRNA-related bone-remodeling disorders, were included.Conclusions: Many circRNAs have been shown to promote osteogenesis and facilitate osteoclast differentiation via diverse mechanisms, and thus modulate the process of bone homeostasis. The imbalance or impairment of these two parts causes diseases, such as osteoporosis, and osteonecrosis of the femoral head, which are also closely correlated to the aberrant presence of circRNAs. Current evidence provides us with promising diagnosis and treatment methods for some bone homeostasis disorders.

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“…This abundant class of molecules is generated from a non-canonical splicing event, called backsplicing, which occurs through the formation of a covalent bond between a downstream splice-donor site and an upstream splice-acceptor site [39]. Along with the ease of purifying from peripheral fluids [68,69] and the high stability, the altered expression of circRNAs in both muscular [70] and cardiovascular pathologies [71] encouraged their use as non-invasive and quantifiable biomarkers. This application is expected to burst in the next few years to diagnose specific pathological states and monitor therapeutic outcomes.…”

Section: Chemical and Structural Properties Define Multiple Arrays Of Rna Functionsmentioning

confidence: 99%

Muscle Regeneration and RNA: New Perspectives for Ancient Molecules

Buonaiuto

Desideri

Taliani

et al. 2021

Cells

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The ability of the ribonucleic acid (RNA) to self-replicate, combined with a unique cocktail of chemical properties, suggested the existence of an RNA world at the origin of life. Nowadays, this hypothesis is supported by innovative high-throughput and biochemical approaches, which definitively revealed the essential contribution of RNA-mediated mechanisms to the regulation of fundamental processes of life. With the recent development of SARS-CoV-2 mRNA-based vaccines, the potential of RNA as a therapeutic tool has received public attention. Due to its intrinsic single-stranded nature and the ease with which it is synthesized in vitro, RNA indeed represents the most suitable tool for the development of drugs encompassing every type of human pathology. The maximum effectiveness and biochemical versatility is achieved in the guise of non-coding RNAs (ncRNAs), which are emerging as multifaceted regulators of tissue specification and homeostasis. Here, we report examples of coding and ncRNAs involved in muscle regeneration and discuss their potential as therapeutic tools. Small ncRNAs, such as miRNA and siRNA, have been successfully applied in the treatment of several diseases. The use of longer molecules, such as lncRNA and circRNA, is less advanced. However, based on the peculiar properties discussed below, they represent an innovative pool of RNA biomarkers and possible targets of clinical value.

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Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Cited by 44 publications

References 67 publications

Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis

Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis

Circular RNAs as potential regulators in bone remodeling: a narrative review

Muscle Regeneration and RNA: New Perspectives for Ancient Molecules

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