Circular RNA in Aging and Age-Related Diseases

Yang, Dapeng; Yang, Katie; Yang, Mingyao

doi:10.1007/978-981-13-1117-8_2

Cited by 28 publications

(14 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, circRNAs have been found to be involved in the development of various diseases, including arteriosclerosis [28], nervous system disorders [29,30], aging [31,32], heart failure [33,34], and malignant tumors [35,36]. In NSCLC, circRNAs have also been shown to play important roles in tumor growth, apoptosis, and metastasis [37][38][39].…”

Section: Aging Discussionmentioning

confidence: 99%

High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis

Jin

Shi

Hua

et al. 2020

Aging

View full text Add to dashboard Cite

Dysregulation of circular RNAs (circRNAs) has recently been shown to play important regulatory roles in cancer development and progression, including non-small cell lung cancer (NSCLC). However, the roles of most circRNAs in NSCLC are still unknown. In this study, we found that hsa_circ_0001421 (circ-SEC31A) was upregulated in NSCLC tissues and cell lines. Increased circ-SEC31A expression in NSCLC was significantly correlated with malignant characteristics and served as an independent risk factor for the post-surgical overall survival of NSCLC patients. Reduced circ-SEC31A expression in NSCLC decreased tumor cell proliferation, migration, invasion, and malate-aspartate metabolism. Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells. Taken together, these results revealed the important role of circ-SEC31A in the proliferation, migration, invasion, and metabolic regulation of NSCLC cells, providing a new perspective on circRNAs in NSCLC progression.

show abstract

Section: Aging Discussionmentioning

confidence: 99%

High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis

Jin

Shi

Hua

et al. 2020

Aging

View full text Add to dashboard Cite

show abstract

“…CircRNAs can act as miRNA sponges to prevent interaction between miRNAs and mRNAs, indirectly regulating the expression of downstream miRNA target genes or affecting gene expression by regulating splicing, transcription and interaction with RNA-binding proteins [107]. CircRNAs have been shown to be good therapeutic targets and diagnostic biomarkers of many diseases and regulate cell proliferation by affecting signaling pathways, transcription factors and cell cycle checkpoint regulators; in addition, circRNAs may be involved in the regulation of aging and aging-related diseases [107][108][109]. circ-foxo3 interacts with the antiaging protein ID-1, transcription factor E2F1, and the antistress proteins FAK and HIF1α [110].…”

Section: Cellular Senescence Is Regulated By Noncoding Rnasmentioning

confidence: 99%

Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease

Yan¹,

Xu²,

Huang³

2021

Aging and disease

View full text Add to dashboard Cite

Ischemic heart disease (IHD) is defined as a syndrome of ischemic cardiomyopathy. Myogenesis and angiogenesis in the ischemic myocardium are important for cardiomyocyte (CM) survival, improving cardiac function and decreasing the progression of heart failure after IHD. Cellular senescence is a state of permanent irreversible cell cycle arrest caused by stress that results in a decline in cellular functions, such as proliferation, migration, homing, and differentiation. In addition, senescent cells produce the senescence-associated secretory phenotype (SASP), which affects the tissue microenvironment and surrounding cells by secreting proinflammatory cytokines, chemokines, growth factors, and extracellular matrix degradation proteins. The accumulation of cardiovascular-related senescent cells, including vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), CMs and progenitor cells, is an important risk factor of cardiovascular diseases, such as vascular aging, atherosclerotic plaque formation, myocardial infarction (MI) and ventricular remodeling. This review summarizes the processes of angiogenesis, myogenesis and cellular senescence after IHD. In addition, this review focuses on the relationship between cellular senescence and cardiovascular disease and the mechanism of cellular senescence. Finally, we discuss a potential therapeutic strategy for MI targeting senescent cells.

show abstract

“…CircRNAs are stable because the lack of free 5′-and 3′-ends protects them against nuclease attack [89]. These circRNAs can function as microRNA sponges to regulate mRNA, ultimately changing gene expression [90]. The expression of circ_0005230 was elevated in human tumors and cholangiocarcinoma (CCA) cells, and it significantly facilitated cell growth, clone-forming ability and metastatic properties and inhibited cell apoptosis in CCA cells.…”

Section: Non-coding Rnas In Invertebrates During Agingmentioning

confidence: 99%

The Epigenetics of Aging in Invertebrates

Gao

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

Aging is an unstoppable process coupled to the loss of physiological function and increased susceptibility to diseases. Epigenetic alteration is one of the hallmarks of aging, which involves changes in DNA methylation patterns, post-translational modification of histones, chromatin remodeling and non-coding RNA interference. Invertebrate model organisms, such as Drosophila melanogaster and Caenorhabditis elegans, have been used to investigate the biological mechanisms of aging because they show, evolutionarily, the conservation of many aspects of aging. In this review, we focus on recent advances in the epigenetic changes of aging with invertebrate models, providing insight into the relationship between epigenetic dynamics and aging. conserved in both insects and mammals, where it regulates the rate of aging [11]. Therefore, this review will summarize recent advances in the roles of epigenetic changes in aging in these two invertebrates. DNA Methylation in Invertebrate AgingDNA methylation is a covalent chemical modification, which usually occurs at 5-methyl cytosine (5mC) and which is enriched in cytosine phosphate guanine (CpG) dinucleotides [12]. CpG methylation within promoters leads to transcriptional repression through the formation of compact chromatin structures such as heterochromatin. Conversely, promoters of genes that are highly expressed are devoid of DNA methylation, hence their name-CpG islands [13]. The dynamic changes in DNA methylation can impact aging and health. The local methylation level increases while the global methylation level decreases with aging [14]. Age-related DNA methylation changes are also correlated with human age-related diseases, such as cancer and sarcopenia [15,16]. Cytosine methylation is catalyzed by three DNA methyltransferases (DNMTs): DNMT1, DNMT3a, and DNMT3b. Three ten-eleven translocation (TET) proteins initiate the specific demethylation of 5mC residues in DNA: TET1, TET2, and TET3 [17]. The schematic diagram of DNA methylation and demethylation is shown in Figure 1. Worms do not encode a conventional DNA methyltransferase to silence DNA repeats, which led to the prevailing view that DNA methylation does not occur in C. elegans [18]. Similarly, in adult D. melanogaster, only a low level of DNA methylation was confirmed [19,20]. In Drosophila, overexpression of the DNA methyltransferase gene, dDnmt2, extends lifespan in a small heat shock protein-dependent way [21]. However, although 5mC methylation is rare, methylation on N6 adenine (6mA) is prevalent in C. elegans and D. melanogaster [22,23]. Recent studies have confirmed that NMAD-1 (MT-A70 family) and DMAD (DNA 6mA demethylase, TET ortholog) are 6mA demethylases in C. elegans and D. melanogaster, respectively. DAMT-1 (AlKB family) is likely a 6mA methyltransferase in C. elegans [24]. NMAD-1 and DAMT-1 can regulate 6mA levels and control the epigenetic inheritance of phenotypes associated with the loss of the H3K4me2 demethylase spr-5 [22]. The worm mutant of spr-5 displayed a transgenerational increase in H3K4me...

show abstract

Circular RNA in Aging and Age-Related Diseases

Cited by 28 publications

References 83 publications

High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis

High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis

Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease

The Epigenetics of Aging in Invertebrates

Contact Info

Product

Resources

About