Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR‐2467‐3p sequestration

Xiao, Hongqi; Liu, Ming

doi:10.1002/jcp.29193

Cited by 54 publications

(30 citation statements)

References 24 publications

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“…[38][39][40] It was reported that circ_0053277 with the high expression level in CRC tissues and cells enhanced cell viability, migration and epithelial-mesenchymal transition process in CRC. 41 In our research, we found that mRNA, suggesting that miR-1184 might regulate PD-L1 expression at a post-transcription level in non-small-cell lung cancer. 21 Similarly, miR-1184 in our study was proved to inhibit the CRC cell phenotypes via suppressing AJUBA expression.…”

Section: F I G U R Ementioning

confidence: 50%

Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa‐miR‐1184 and releasing AJUBA and inactivating Hippo/YAP signalling

Wang

Chen

Liu

et al. 2020

J Cellular Molecular Medi

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Hsa_circ_0128846 was found to be the most significantly up‐regulated circRNA in our bioinformatics analysis. However, the role of hsa_circ_0128846 in colorectal cancer has not been explored. We thus aim to explore the influence and mechanism of hsa_circ_0128846 in colorectal cancer by sponging its downstream miRNA target miR‐1184. We collected 40 colorectal cancer patients’ tumour tissues to analyse the expression of hsa_circ_0128846, miR‐1184 and AJUBA using qRT‐PCR and Western blot where needed. Then, we constructed stably transfected SW480 and HCT116 cells to study the influence of hsa_circ_0128846, miR‐1184 and AJUBA on colorectal cancer cell phenotypes. To obtain reliable results, a plethora of experiments including RNA immunoprecipitation assay, flow cytometry, EdU incorporation assay, wound healing migration assay, transwell invasion assay and live imaging of nude mice xenograft assay were performed. The binding relationship between hsa_circ_0128846, miR‐1184 and AJUBA mRNA in colorectal cancer was validated by reported gene assay. In colorectal cancer tissues, circ_0128846 and AJUBA were both significantly up‐regulated, while miR‐1184 was significantly down‐regulated compared with healthy tissues. Meanwhile, hsa_circ_0128846 can absorb miR‐1184 to promote the progression of CRC in vivo and SW480 and HCT116 cell phenotypes in vitro. The knockdown of AJUBA, a downstream target of miR‐1184, reversed the effect of miR‐1184 in CRC cells via enhancing the phosphorylation of the Hippo/YAP signalling pathway proteins MST1, LATS1 and YAP. This study revealed that hsa_circ_0128846 contributed to the development of CRC by decreasing the expression of miR‐1184, thereby increasing AJUBA expression and inactivating Hippo/YAP signalling.

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Section: F I G U R Ementioning

confidence: 50%

Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa‐miR‐1184 and releasing AJUBA and inactivating Hippo/YAP signalling

Wang

Chen

Liu

et al. 2020

J Cellular Molecular Medi

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“…MMP14 was reported to degrade the ECM by increasing the secretion of pro-MMP2, pro-MMP9, and interacting with TIMP2 [47]. Furthermore, hsa_circ_0053277 was remarkably upregulated in CRC tissues and cells, which contributed to tumor cell invasion by sponging miR-2467-3p to target MMP14 [48] (Fig. 1) ( Table 1).…”

Section: Degradation Of the Basement Membrane And Interstitial Connecmentioning

confidence: 97%

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Shao

Lü

2020

Cancer Cell Int

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Background Carcinomas are highly heterogeneous with regard to various cancer cells within a tumor microenvironment (TME), which is composed of stromal cells, blood vessels, immunocytes, and modified extracellular matrix. Focus of the study Circular RNAs (circRNAs) are non-coding RNAs that are expressed in cancer and stromal cells. They are closely associated with cancer metastasis as their expression in tumor cells directs the latter to migrate to different organs. circRNAs packaged in exosomes might be involved in this process. This is particularly important as the TME acts in tandem with cancer cells to enhance their proliferation and metastatic capability. In this review, we focus on recent studies on the crosstalk between circRNAs and the TME during cancer metastasis. Conclusion We particularly emphasize the roles of the interaction between circRNAs and the TME in anoikis resistance, vessel co-option, and local circRNA expression in directing homing of exosome.

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“…Interestingly, several circRNAs exert their function as promoters or inhibitors of metastasis via modulating key signaling pathways in CRC, including Wnt/β-catenin [ 90 ], Ras [ 79 ], and Hippo-YAP [ 39 ]. Finally, some circRNAs seem to interact with matrix metallopeptidases, particularly with MMP2 [ 69 ] and MMP14 [ 77 ]. These enzymes are essential for extracellular matrix degradation, thus promoting EMT and metastasis.…”

Section: Metastasis and Invasionmentioning

confidence: 99%

Circular RNAs: A New Piece in the Colorectal Cancer Puzzle

Artemaki

Scorilas

Kontos

2020

Cancers

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Colorectal cancer (CRC) is the third most fatal type of malignancy, worldwide. Despite the advances accomplished in the elucidation of its molecular base and the existing CRC biomarkers introduced in the clinical practice, additional research is required. Circular RNAs (circRNAs) constitute a new RNA type, formed by back-splicing of primary transcripts. They have been discovered during the 1970s but were characterized as by-products of aberrant splicing. However, the modern high-throughput approaches uncovered their widespread expression; therefore, several questions were raised regarding their potential biological roles. During the last years, great progress has been achieved in the elucidation of their functions: circRNAs can act as microRNA sponges, transcription regulators, and interfere with splicing, as well. Furthermore, they are heavily involved in various human pathological states, including cancer, and could serve as diagnostic and prognostic biomarkers in several diseases. Particularly in CRC, aberrant expression of circRNAs has been observed. More specifically, these molecules either inhibit or promote colorectal carcinogenesis by regulating different molecules and signaling pathways. The present review discusses the characteristics and functions of circRNA, prior to analyzing the multifaceted role of these molecules in CRC and their potential value as biomarkers and therapeutic targets.

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Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR‐2467‐3p sequestration

Cited by 54 publications

References 24 publications

Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa‐miR‐1184 and releasing AJUBA and inactivating Hippo/YAP signalling

Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa‐miR‐1184 and releasing AJUBA and inactivating Hippo/YAP signalling

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Circular RNAs: A New Piece in the Colorectal Cancer Puzzle

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