Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non‐small cell lung carcinoma via modulating miR‐488/ZNF281 axis

Gu, Runhuan; Shao, Koufeng; Xu, Qiaoxia; Zhao, Xue; Qiu, Haibing; Hu, Haibo

doi:10.1111/jcmm.15987

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…A previous report revealed that circ_0008003 participated in NSCLC progress, and circ_0008003 promotes NSCLC cell invasion and proliferation in vitro 13 . Consistently, this study also found that the expression of circ_0008003 was highly expressed in NSCLC tissues and cells.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies have suggested that circRNAs can act as “microRNAs (miRNA) sponges” and participate in the regulation of tumor progress 9–12 . Hu et al found that circ_ 0008003 can participate in the regulation of the occurrence and development of NSCLC, and part of this is to act as a sponge of mir‐488, which was proven to be a tumor suppressor in some tumor diseases 13,14 . Although some studies have proposed relevant molecular mechanisms of circRNAs and miRNAs in NSCLC, further studies are needed to elucidate the regulatory network of circRNAs and their downstream factors.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNA hsa_circ_0008003 promotes the progression of non–small‐cell lung cancer by sponging miR‐548I and regulating KPNA4 expression

et al. 2022

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Objective The study aimed to explore the effect of circ_0008003 on the progression of non–small‐cell lung cancer (NSCLC) and its underlying regulation mechanism. Methods Expression of hsa_circ_0008003, miRNA (miR)‐548I and karyopherin subunit α 4 ( KPNA4 ) was examined by quantitative real‐time polymerase chain reaction. Cell viability and proliferation ability were detected by cell counting kit‐8 assay and 5‐ethynyl‐2′‐deoxyuridine assay, respectively. Flow cytometry was performed to monitor cell apoptosis. Western blot assay was used to evaluate the protein levels of KPNA4, Bax, and Bcl‐2. Cell migration and invasion were assessed by transwell assays. The targeted relationship between miR‐548I and hsa_circ_0008003 or KPNA4 was confirmed by dual‐luciferase reporter and RNA immunoprecipitation assays. Furthermore, the role of hsa_circ_0008003 in vivo was investigated by xenograft assay. Results Circ_0008003 expression was increased in NSCLC tissues and cell lines. Circ_0008003 knockdown reduced cell viability, migration, invasion, angiogenesis, and caused apoptosis in NSCLC cells. Moreover, miR‐548I was targeted by circ_0008003, and miR‐548I knockdown reversed the influence of circ_0008003 silence on NSCLC progression. KPNA4 was targeted by miR‐548I, and miR‐548I overexpression suppressed cell viability, migration, invasion, angiogenesis, and promoted cell apoptosis via decreasing KPNA4 . In addition, circ_0008003 regulated KPNA4 expression via miR‐548I. Circ_0008003 knockdown decreased NSCLC cell growth in the xenograft model. Conclusion Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR‐548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0008003 promotes the progression of non–small‐cell lung cancer by sponging miR‐548I and regulating KPNA4 expression

et al. 2022

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“…3B: the vector panel appears similar to the sh-circ-0008003 panel in Fig. 2D in a previously-published article by different authors [ 2 ]; In Fig. 7B, the LINC00337 panel appears similar to the LINC01705 OE panel in Fig.…”

supporting

confidence: 58%

“…3B: the vector panel appears similar to the sh-circ-0008003 panel in Fig. 2D in a previously-published article by different authors [ 2 ];…”

mentioning

confidence: 60%

Retraction Note: LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

Zhang,

Wu,

et al. 2024

Cancer Cell Int

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CircSFMBT2 Plays an Oncogenic Role in Lung Adenocarcinoma Depending on the miR-1305/SALL4 Axis

Zhao,

Xing,

2023

Biochem Genet

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Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non‐small cell lung carcinoma via modulating miR‐488/ZNF281 axis

Cited by 10 publications

References 51 publications

Circular RNA hsa_circ_0008003 promotes the progression of non–small‐cell lung cancer by sponging miR‐548I and regulating KPNA4 expression

Circular RNA hsa_circ_0008003 promotes the progression of non–small‐cell lung cancer by sponging miR‐548I and regulating KPNA4 expression

Retraction Note: LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

CircSFMBT2 Plays an Oncogenic Role in Lung Adenocarcinoma Depending on the miR-1305/SALL4 Axis

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