Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231

Li, Yating; Li, Yang; Li, Linfeng

doi:10.1007/s00403-020-02174-y

Cited by 8 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The only circRNA dysregulated in BCC subjected to functional characterization is hsa_circ_0005795. Upregulation of this circRNA in BCC, initially described by Sand et al [77], was confirmed in a recent study of tissue samples from BCC patients and cell lines (A431 and TE345.T) [78]. Increased expression of hsa_circ_0005795 was detected in 23/30 nodular BCC samples.…”

Section: Circrnas In Bccmentioning

confidence: 61%

See 1 more Smart Citation

The Role of Circular RNAs in Keratinocyte Carcinomas

Meyer

Sand

Schmitz³

et al. 2021

Cancers

View full text Add to dashboard Cite

Keratinocyte carcinomas (KC) include basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC) and represents the most common cancer in Europe and North America. Both entities are characterized by a very high mutational burden, mainly UV signature mutations. Predominately mutated genes in BCC belong to the sonic hedgehog pathway, whereas, in cSCC, TP53, CDKN2A, NOTCH1/2 and others are most frequently mutated. In addition, the dysregulation of factors associated with epithelial to mesenchymal transition (EMT) was shown in invasive cSCC. The expression of factors associated with tumorigenesis can be controlled in several ways and include non-coding RNA molecules, such as micro RNAs (miRNA) long noncoding RNAs (lncRNA) and circular RNAs (circRNA). To update findings on circRNA in KC, we reviewed 13 papers published since 2016, identified in a PubMed search. In both BCC and cSCC, numerous circRNAs were identified that were differently expressed compared to healthy skin. Some of them were shown to target miRNAs that are also dysregulated in KC. Moreover, some studies confirmed the biological functions of individual circRNAs involved in cancer development. Thus, circRNAs may be used as biomarkers of disease and disease progression and represent potential targets of new therapeutic approaches for KC.

show abstract

Section: Circrnas In Bccmentioning

confidence: 61%

“…al. [77] was confirmed in a subsequent study that found elevated hsa_circ_0005795 expression in most (23/30), but not all, nodular BCC samples [78]. Thus, upregulation of this circRNA appears not to be a common feature of BCC.…”

Section: Future Perspectivesmentioning

confidence: 76%

The Role of Circular RNAs in Keratinocyte Carcinomas

Meyer

Sand

Schmitz³

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…5,6 More and more circR-NAs have been reported as promoters or suppressors in the initiation of various human cancers, containing CSCC. [7][8][9] CircRNA expression profile showed that circ_0068631 (chr3: derived from transferrin receptor gene was upregulated in CSCC.…”

Section: Introductionmentioning

confidence: 99%

Circ_0068631 sponges miR‐139‐5p to promote the growth and metastasis of cutaneous squamous cell carcinoma by upregulating HOXB7

Xiong

Peng

et al. 2023

Skin Research and Technology

View full text Add to dashboard Cite

Background Circular RNAs (circRNAs) are often dysregulated in cancers and closely related to cancer progression, including cutaneous squamous cell carcinoma (CSCC). However, the role and mechanism of circ_0068631 in CSCC progression have not been reported. Methods The expression of circ_0068631, microRNA‐139‐5p (miR‐139‐5p), and homeobox B7 (HOXB7) was measured by real‐time quantitative polymerase chain reaction (RT‐qPCR). Cell counting kit‐8 (CCK‐8) assay, 5‐ethynyl‐2′‐deoxyuridine (EdU) assay, and colony formation assay were used to measure cell proliferation. Cell apoptosis was assessed by flow cytometry. Cell migration was detected by transwell assay. The interaction between miR‐139‐5p and circ_0068631 or HOXB7 was confirmed by dual‐luciferase reporter assay. A xenograft tumor model was established to confirm the function of circ_0068631 in vivo. Results Circ_0068631 was upregulated in CSCC tissues and cells, and its silencing could inhibit CSCC cell proliferation and metastasis while promoting apoptosis in vitro, as well as restrain CSCC tumor growth in vivo. Circ_0068631 acted as a sponge of miR‐139‐5p, and miR‐139‐5p inhibition reversed the repressive effect of circ_0068631 knockdown on CSCC cell progression. Furthermore, HOXB7 was a target of miR‐139‐5p, and miR‐139‐5p inhibited the malignant behaviors by downregulating HOXB7 expression in CSCC cells. Further, circ_0068631 sponged miR‐139‐5p to regulate HOXB7 expression. Conclusion Circ_0068631 functioned as a novel oncogene in CSCC progression by regulating miR‐139‐5p/HOXB7 axis, suggesting that circ_0068631 may be a potential target for CSCC treatment. Highlights Circ_0068631 was overexpressed in CSCC tissues and cells. Circ_0068631 downregulation suppressed CSCC progression via miR‐139‐5p. Circ_0068631 regulated HOXB7 via sponging miR‐139‐5p.

show abstract

“…Circular RNAs (circRNA), a group of endogenous RNA molecules with unique closed cyclic structures, have high stability and tissue-specific/developmental-stage-specific expression pattern [ 9 – 12 ]. Recently, the dysregulation of circRNAs have been found in various tumors, including basal cell carcinoma [ 13 , 14 ], colorectal cancer [ 15 , 16 ], hepatocellular carcinoma [ 17 , 18 ], and GC [ 19 ], indicating their crucial roles in cancer development. circRNAs exhibit multiple functions in cancer pathogenesis and progression, such as functioning as microRNA (miRNA) sponges [ 20 , 21 ] or serving as templates for protein synthesis [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer

Yuan

Zhang

et al. 2022

Cell Death Dis

View full text Add to dashboard Cite

Circular RNAs (circRNAs) have been reported to play essential roles in tumorigenesis and progression. This study aimed to identify dysregulated circRNAs in gastric cancer (GC) and investigate the functions and underlying mechanism of these circRNAs in GC development. Here, we identify circ_CEA, a circRNA derived from the back-splicing of CEA cell adhesion molecule 5 (CEA) gene, as a novel oncogenic driver of GC. Circ_CEA is significantly upregulated in GC tissues and cell lines. Circ_CEA knockdown suppresses GC progression, and enhances stress-induced apoptosis in vitro and in vivo. Mechanistically, circ_CEA interacts with p53 and cyclin-dependent kinases 1 (CDK1) proteins. It serves as a scaffold to enhance the association between p53 and CDK1. As a result, circ_CEA promotes CDK1-mediated p53 phosphorylation at Ser315, then decreases p53 nuclear retention and suppresses its activity, leading to the downregulation of p53 target genes associated with apoptosis. These findings suggest that circ_CEA protects GC cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and CDK1 proteins. Combinational therapy of targeting circ_CEA and chemo-drug caused more cell apoptosis, decreased tumor volume and alleviated side effect induced by chemo-drug. Therefore, targeting circ_CEA might present a novel treatment strategy for GC.

show abstract

Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231

Cited by 8 publications

References 35 publications

The Role of Circular RNAs in Keratinocyte Carcinomas

The Role of Circular RNAs in Keratinocyte Carcinomas

Circ_0068631 sponges miR‐139‐5p to promote the growth and metastasis of cutaneous squamous cell carcinoma by upregulating HOXB7

Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer

Contact Info

Product

Resources

About