Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis

Zhu, Jie; Liu, Xiaobin; Luan, Zhonghua; Xue, Wei; Cui, Haizheng; Zhang, Baochen; Xue, Guoqiang

doi:10.1007/s11011-022-00915-8

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…After reviewing the literature, we found that, through sponging with specific miRNAs, circRNAs could regulate the expression of miRNA-targeted mRNAs and lead to the inhibition or promotion of tumour progression [ 6 , 28 ]. To identify the direct target(s) of circRNA_0084043 during glioma progression, the Circular RNA Interactome and starBase databases were searched.…”

Section: Resultsmentioning

confidence: 99%

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

Qian,

Chen,

Zhao

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

Qian,

Chen,

Zhao

et al. 2023

Heliyon

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“…Possessing numerous binding sites allows circRNAs to regulate carcinogenesis or anticarcinogenesis by interacting with target molecules, typically miRNAs, which are widely known for their ability to target mRNAs. The network composed of circRNA-miRNA-mRNA and its functional mechanisms have been reported in hepatocellular carcinoma 8 , lung adenocarcinoma 9 , bladder cancer 10 , breast cancer 11 as well as gliomas [12][13][14] . CircRNAs that are relevant have been found to exhibit differential expression in tumors and can play a crucial role in tumor biology by modulating key molecules in downstream signaling pathways through sponging miRNAs.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Functional circRNA-miRNA-mRNA Network and Inhibitory Effect of Hsa_circ_0001681 on Gliomas

Cheng,

Chen,

Sun

et al. 2023

Preprint

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Background Gliomas seriously threaten the health and safety of patients globally with significant morbidity and mortality. An increasing number of studies have confirmed the close correlation between circular RNAs (circRNAs) and the occurrence and development of cancer. However, the association between circRNAs and their downstream networks with gliomas remains unclear. Results Our study identified 4 significantly differentially expressed circRNAs through the glioma expression profile from the Gene Expression Omnibus database. A total of 125 circRNA-targeted microRNAs (miRNAs) were predicted using the Circular RNA Interactome database, 15 of which were selected for further mining from intersection analysis. A total of 2635 miRNA-targeted mRNAs were predicted using the miRNet database, thus establishing the circRNA-miRNA-mRNA network. Functional enrichment pathway analyses revealed that the mRNAs contained in the network were enriched in a variety of DNA- or RNA-related transcription regulatory processes and pathways in cancer. Hsa_circ_0001681 was further identified as a hub circRNA and validated by Sanger sequencing and RT-PCR. Cell biology experiments and xenograft models revealed that hsa_circ_0001681 played an anticarcinogenic role in gliomas both in vitro and in vivo. Conclusions Our results identified and indicated the crucial role of circRNA-miRNA-mRNA network in gliomas and supported the potential of hsa_circ_0001681 as a diagnostic and therapeutic target biomarker.

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“…After reviewing the literature, we found that, through sponging with speci c miRNAs, circRNAs could regulate the expression of miRNA-targeted mRNAs and lead to the inhibition or promotion of tumour progression (Cheng et al, 2021;Zhu et al, 2022). To identify the direct target(s) of circRNA_0084043 during glioma progression, the Circular RNA Interactome and starBase databases were searched.…”

Section: Circrna_0084043 Acting As a Sponge For Mir-577mentioning

confidence: 99%

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

Zhang

et al. 2022

Preprint

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Circular RNAs (circRNAs) are important non-coding RNAs (ncRNAs) involved in the development of multiple human diseases, especially cancers. circRNA_0084043 is significantly involved in the progression of melanoma. However, whether circRNA_0084043 is associated with glioma remains unknown. In this study, the upregulation of circRNA_0084043 in glioma and the association between circRNA_0084043 and glioma grade were identified. Our results showed that circRNA_0084043 is significantly involved in the proliferative, migratory, and invasive capacities of glioma cells. The results obtained from starBase, luciferase reporter assays, RNA immunoprecipitation assays, and RNA pull-down assays demonstrated that circRNA_0084043 acts as a direct sponge for miR-577. To identify the potential target of miR-577, analysis was conducted using the TargetScan algorithm, and results showed that SNX5 is a candidate miRNA for miR-577 binding. Finally, glioma cell growth, migration, and invasion were significantly enhanced by circRNA_0084043 by regulating the expression of miR-577-mediated SNX5 expression via miR-577 sponging. Taken together, we concluded that circRNA_0084043 in the miR-577/SNX5 axis can be used as a candidate target for glioma therapy.

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Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis

Cited by 4 publications

References 28 publications

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

Identification of a Functional circRNA-miRNA-mRNA Network and Inhibitory Effect of Hsa_circ_0001681 on Gliomas

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging

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